Solid-liquid mixture capable of being solidified into polyvinyl alcohol hydrogel in real time under temperature control and preparation method thereof

Abstract

The present invention belongs to the technical field of hydrogels, aims to solve a problem that hydrogel solidification time is difficult to control in the prior art, and provides a solid-liquid mixture capable of being solidified into a polyvinyl alcohol hydrogel in real time under temperature control. The solid-liquid mixture comprises a polyvinyl alcohol aqueous solution and hydrophobic microcapsule particles dispersed in the polyvinyl alcohol aqueous solution, the hydrophobic microcapsule particles are composed of capsule-forming materials and solid sodium tetraborate particles encapsulated in the capsule-forming materials, and a melting temperature of the capsule-forming materials is between 30 and 70 DEG C. The polyvinyl alcohol aqueous solution and sodium tetraborate are used to rapidly conduct a gel reaction, the sodium tetraborate particles are encapsulated in the hydrophobic microcapsule particles, after the solid-liquid mixture fills wounds, heating is conducted to promote melting of the hydrophobic microcapsules to release the sodium tetraborate solid particles and enable the sodium tetraborate solid particles and the polyvinyl alcohol aqueous solution to rapidly conduct the gel reaction, real-time precise control of gel is realized and applications of the hydrogels in the field of medicine are expanded.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to a solid-liquid mixture capable of solidifying into polyvinyl alcohol hydrogel in real time under temperature control and a preparation method thereof. Background technique [0002] Hydrogel is a general term for a class of gel-like polymer materials with a three-dimensional network structure and high water content. Because of its good viscoelasticity, strong plasticity and good biocompatibility, it has been applied in the fields of medical transplantation, biosensing, and controlled drug release. Hydrogel dressings have high water content, excellent water retention, and excellent tissue bonding strength, which can maintain a proper moist repair environment for large area burns, trauma, and wounds with skin and tissue defects caused by surgery , effectively relieve pain and accelerate wound healing. [0003] The formation and curing time of existing hydrogels are g...

AI Technical Summary

Problems solved by technology

Polyvinyl alcohol aqueous solution and sodium tetraborate aqueous solution can react rapidly under neutral or alkaline conditions to form hydrogel, which can solve the problem that the above-mentioned hydrogel curing time is too long, but its reaction is too fast, which is not conducive to the formation of hydrogel before flow molding, which limits its application