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A personal care composition

A personal care, composition technology, applied in the direction of oral care, drug combination, preparations for skin care, etc.

Active Publication Date: 2019-04-16
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although one or more of the above processes are associated with acne, a trigger and the exact sequence of events leading to the formation of acne lesions is not fully understood

Method used

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Experimental program
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Effect test

preparation example Construction

[0040] 6-gingeriol is generally absent or present in ginger at less than 0.001%, and therefore cannot be considered to occur naturally in ginger. According to the present invention, gingerdiol used in the composition of the present invention must be synthesized in a chemical reaction. A suitable chemical synthesis method includes the following steps: placing gingerol in a suitable solvent and reducing agent at a temperature of 0-10°C; warming the reaction mixture to 15-25°C to form gingeriol; and extracting gingerol using solvent extraction. Gingeriol was separated from the mixture.

[0041] The various possible chemical substances and process conditions that can be used to prepare gingeriol are given below:

[0042] Suitable solvents for chemical synthesis include: alcohols such as methanol, ethanol, isopropanol, n-butanol, sec-butanol, tert-butanol, pentanol, isoamyl alcohol, tert-amyl alcohol; ethers such as tetrahydrofuran, 2-Methyltetrahydrofuran, methyl tert-butyl ethe...

Embodiment 1-4

[0112] Example 1-4: Synergistic anti-inflammatory effect of 6-gingerdiol and nicotinamide in THP-1 in vitro assay

[0113] The following procedure was used to test the anti-inflammatory efficacy of various active substances alone or in combination

[0114] THP1-XBlue TM (Cat. No.: thpx-sp, InvivoGen) Cells were cultured in suspension in RPMI 1640 medium supplemented with 10% FBS, penicillin (10 U / mL)-streptomycin (10 μg / ML). cells at a density of 5 x 10 5 Cells / well were differentiated for 72 h in 24-well culture plates with 100 nM PMA. Cells were subsequently co-treated with pure E. coli lipopolysaccharide (LPS) in combination with a single concentration or different doses of 6-gingeriol and nicotinamide. After 24 h, supernatants were collected and interleukin (IL)-6 was measured as a pro-inflammatory biomarker using enzyme-linked immunosorbent assay (ELISA).

[0115] The results for concentrations of IL-6 (in pg / ml) are provided in Table 1 below:

[0116] Table 1

[01...

Embodiment 5-10

[0118] Examples 5-10: Synergistic anti-inflammatory efficacy of 6-gingerdiol and nicotinamide at various other concentrations in the THP-1 in vitro assay

[0119] Experiments similar to those in Table 1 were performed and similar synergy data were obtained with various other concentrations. The data are summarized in Table 2 below:

[0120] Table 2

[0121]

[0122] The data in Tables 1 and 2 demonstrate the synergistic efficacy of the combination of niacinamide and 6-gingeriol and this is applicable to many different concentrations.

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Abstract

The invention relates to a personal care composition that is primarily directed to prevent or reduce inflammation in topical cells. It could be delivered in the form of an oral care, hair / scalp care or skin care composition and comprises gingerdiol in combination with a vitamin B3 compound.

Description

technical field [0001] The present invention relates to a personal care composition, and more particularly to a composition for preventing or relieving inflammation that is applied to a topical surface or oral cavity of a human or animal. The composition may be delivered in the form of a skin care, scalp care, hair care or oral care product. Background technique [0002] Inflammation, a complex biological host response to noxious stimuli, is a mechanism by which the host removes the stimulus and initiates a healing process for self-preservation. The host's innate immune system is the first line of defense against organisms that invade in a nonspecific manner. Dysregulated inflammation can cause a variety of personal care issues including gingivitis / periodontitis (in the mouth), dandruff (on the scalp / hair) and eczema / acne (on the skin). To assist the host organism (eg, human or animal), various anti-inflammatory agents, either via topical application or via oral administra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/67A61Q11/00A61Q19/00A61P17/00
CPCA61K8/347A61K8/675A61Q11/00A61Q19/00A61P17/00
Inventor 陈钰C·R·哈丁B·哈里奇安黄丹丹J·G·罗萨周鲁先
Owner UNILEVER IP HLDG BV
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