Promotion of healing of intestinal mucosa using proline, serine and threonine

A technology of proline and serine, which is applied in the field of health and nutrition, can solve the problems that the role of dietary supplements has not been fully studied, and there is no treatment for IBD patients with mucosal healing, so as to restore intestinal barrier function, repair intestinal epithelial cells, and promote The effect of protection
CN107105751AInactive Publication Date: 2017-08-29SOC DES PROD NESTLE SA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOC DES PROD NESTLE SA
Publication Date
2017-08-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods and compositions are provided that use proline, serine and threonine to promote healing of the intestinal mucosa. A therapeutically effective amount of proline, serine and threonine is administered to an individual in need thereof, for example a human or other mammal, such as an individual that has damaged intestinal mucosa. The methods and compositions can promote mucosal healing, restore gut barrier function, repair intestinal epithelial cells, promote protection of the colonic epithelium, and / or promote the replenishment of goblet cells in the intestinal and colonic mucosa.
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Description

Background technique

[0001] This disclosure generally relates to health and nutrition. More specifically, the present disclosure relates to methods and compositions for promoting intestinal mucosal healing using proline, serine, and threonine.

[0002] The mucosa is the innermost layer of the gastrointestinal tract and surrounds the lumen passing through the gastrointestinal tract. The gastrointestinal mucosa is formed by the innermost layer, the epithelium; a thin layer of smooth muscle surrounding the skin, the muscular mucosa; and a layer of connective tissue between the epithelium and the muscular mucosa, the lamina propria.

[0003] Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, are characterized not only by mucosal inflammation but also by severe impairment of intestinal barrier function. Recent clinical studies have characterized "mucosal healing" as the most significant prognostic factor for long-term remission in IBD patients a...

Claims

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