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Method for synthesizing gold nanoparticles based on notoginsenoside

A technology of nano-gold particles and notoginseng saponin, which is applied in the field of analysis and research of nano-particle characteristics, can solve the problems of unfavorable nano-particle surface modification application and high price, and achieve low overall cost, good repeatability and simple operation process Effect

Active Publication Date: 2019-04-23
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In summary, the problems in the prior art are: At present, some methods of chemically synthesizing nanomaterials use expensive and toxic reagents as reducing agents, stabilizers or structure-directing reagents, which are not conducive to the surface modification of nanoparticles and further applications in biomedicine, food safety testing, and environmental testing. field application

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  • Method for synthesizing gold nanoparticles based on notoginsenoside
  • Method for synthesizing gold nanoparticles based on notoginsenoside
  • Method for synthesizing gold nanoparticles based on notoginsenoside

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preparation example Construction

[0021] The invention can conveniently prepare gold nano-sphere particles or gold nano-spun-like structures in one step. When more notoginsenosides are added, no matter whether sodium hydroxide solution is added or not, nano-gold sphere particles with a size of about 20nm can be obtained, and the maximum spectral absorption peak of the solution is about 570nm. When a small amount of notoginsenoside is added, nano-gold particles with a micron-level spun-like structure can be obtained. The surface of the gold nanoparticles can adsorb notoginsenoside and its oxidation products, while the spherical particles can better enter the cell interior to achieve biological effects. By comparing the biological activity of the spherical gold nanoparticles, it can be seen that the gold nanoparticles added with sodium hydroxide have a better anti-cancer activity and a better killing effect on human lung cancer cells (NCl-H292). When nano-gold particles enter lung cancer cells, they can promote ...

Embodiment 1

[0029] The specific steps are:

[0030] 1) Dilute 515μL of 1% chloroauric acid solution and 10mL of 1mg / mL panax notoginsenoside R1 (NGR1) solution to 50mL to obtain a mixed solution of chloroauric acid and notoginsenoside, and stir the reaction in the thermal magnetic force. Stir evenly on the device.

[0031] 2) Take 10μL of 1mol / L sodium hydroxide solution and add it to the above mixed solution, then keep stirring and heating to boiling on the heat collecting magnetic stirring reactor, keep the boiling reaction in the reflux state for 30min to obtain brick red or wine The red colloidal solution, naturally cool to room temperature for later use.

[0032] 3) Take appropriate amount of colloidal solution and perform UV-Vis spectrophotometer (UV-Vis) and transmission electron microscope (TEM) test and analysis respectively. Among them, the UV-Vis spectrum is as follows image 3 As shown in B, it can be seen from the figure that the maximum absorption peak of the nano-gold colloidal ...

Embodiment 2

[0037] The specific steps are:

[0038] 1) Dilute 515μL of 1% chloroauric acid solution and 5mL of 1mg / mL panax notoginsenoside R1 (NGR1) solution to 50mL respectively to obtain a mixed solution of chloroauric acid and notoginsenoside, and stir the reaction in the thermal magnetic force. Stir evenly on the device.

[0039] 2) Take 10μL of 1mol / L sodium hydroxide solution and add it to the above mixed solution, then keep stirring and heating to boiling on the heat collecting magnetic stirring reactor, keep the boiling reaction in the reflux state for 30min to obtain brick red or wine The red colloidal solution, naturally cool to room temperature for later use.

[0040] 3) Take appropriate amount of colloidal solution and perform UV-Vis spectrophotometer (UV-Vis) and transmission electron microscope (TEM) test and analysis, respectively, the results are as follows image 3 B and Figure 5 Shown in B. It can be seen from the figure that the absorption spectrum of the nano-gold colloid...

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Abstract

The invention belongs to the technical field of manufacturing metal powder or suspension of the metal powder, and discloses a method for synthesizing gold nanoparticles based on notoginsenoside. The method includes steps that firstly, 50 mL of 0.25-mM chloroauric acid HAuCl4 and notoginsenoside R1 of 0.2 mg per mL are mixed in a round bottom flask; secondly, 1 M of sodium hydroxide (NaOH) solutionis added, the mixture is heated to boiling, the boiling reaction is maintained in the reflux state for at least 30 min, and then the mixture is naturally cooled to room temperature for use; and finally, UV-visible spectrophotometer, transmission electron microscope and biological toxicity testing experiments are respectively carried out on the basis of the prepared colloidal solution. The methodis low in cost, easy in operation, adjustable in processing, good in repeatability, stable and reliable. The core of the method is to control and prepare the gold nanoparticles with different particlesizes and shapes by controlling different amounts of reactants and finely controlling the synthesis process.

Description

Technical field [0001] The invention belongs to the field of nano-material science, and in particular relates to a method for preparing nano-gold particles based on the reduction of notoginseng saponins and analysis of the characteristics of the nano-particles. Background technique [0002] Gold nanoparticles (AuNPs: gold nanoparticles) have unique physical and chemical properties. Based on these characteristics, nano-gold particles have exerted extensive and far-reaching influence in the fields of biosensing and imaging, chemical measurement and analysis, catalysis, and surface and interface science. The synthesis of nano-gold particles with controllable size and shape is the key to expanding and strengthening its application fields. Generally, the main methods for preparing nanoparticles are chemical and physical methods. Physical methods often require large amounts of energy to achieve high temperatures and pressures or time-consuming processes to achieve nanoparticle synthe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B82Y40/00
CPCB82Y40/00B22F9/24B22F2009/245
Inventor 汤俊琪石俊生欧全宏满石清周薇薇
Owner YUNNAN NORMAL UNIV