Star polymer drug carrier and preparation method thereof
A star-shaped polymer and drug technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and emulsion delivery, etc., can solve the problems of insufficient stability of micelles, easy to cause immune reactions, etc., and achieve good biocompatibility , the effect of long cycle time
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Embodiment 1
[0028] Synthesis of the macromolecular initiator 4-arm-PEG-Br: First, weigh 300mg 4-arm-PEG-OH and place it in a three-neck flask equipped with a nitrogen inlet, a nitrogen outlet and a constant pressure dropping funnel, and pour into it Add 10mL CH 2 Cl 2 . Then 0.022g DMAP and 17uL TEA were added thereto. Add 37uL BIBB and 10mL CH to the constant pressure dropping funnel 2 Cl 2 , when BIBB is completely dissolved in CH 2 Cl 2 Afterwards, it was slowly added dropwise to a three-neck flask under ice bath and nitrogen protection conditions. After the dropwise addition was completed, the reaction was carried out at room temperature for 24 h. After the reaction was completed, the solvent CH was evaporated by rotary evaporation2 Cl 2 After removal, the product was dissolved in distilled water, dialyzed in distilled water for 48 hours with a dialysis bag (Mw=1000), and freeze-dried to obtain 4-arm-PEG-Br.
[0029] Synthesis of 4-arm-PEG-PMPC block copolymer: Weigh 4.3mg Cu...
Embodiment 2
[0032] Synthesis of the macromolecular initiator 4-arm-PEG-Br: First, weigh 300mg 4-arm-PEG-OH and place it in a three-neck flask equipped with a nitrogen inlet, a nitrogen outlet and a constant pressure dropping funnel, and pour into it Add 10mL CH 2 Cl 2 . Then 0.022g DMAP and 17uL TEA were added thereto. Add 37uL BIBB and 10mL CH to the constant pressure dropping funnel 2 Cl 2 , when BIBB is completely dissolved in CH 2 Cl 2 Afterwards, it was slowly added dropwise to a three-neck flask under ice bath and nitrogen protection conditions. After the dropwise addition was completed, the reaction was carried out at room temperature for 24 h. After the reaction was completed, the solvent CH was evaporated by rotary evaporation 2 Cl 2 After removal, the product was dissolved in distilled water, dialyzed in distilled water for 48 hours with a dialysis bag (Mw=1000), and freeze-dried to obtain 4-arm-PEG-Br.
[0033] Synthesis of 4-arm-PEG-PMPC block copolymer: Weigh 4.3mg ...
Embodiment 3
[0036] Synthesis of the macromolecular initiator 4-arm-PEG-Br: First, weigh 300mg 4-arm-PEG-OH and place it in a three-neck flask equipped with a nitrogen inlet, a nitrogen outlet and a constant pressure dropping funnel, and pour into it Add 10mL CH 2 Cl 2 . Then 0.033g DMAP and 34uL TEA were added thereto. Add 55.5uL BIBB and 15mL CH to the constant pressure dropping funnel 2 Cl 2 , when BIBB is completely dissolved in CH 2 Cl 2 Afterwards, it was slowly added dropwise to a three-neck flask under ice bath and nitrogen protection conditions. After the dropwise addition was completed, the reaction was carried out at room temperature for 24 h. After the reaction was completed, the solvent CH was evaporated by rotary evaporation 2 Cl 2 After removal, the product was dissolved in distilled water, dialyzed in distilled water for 48 hours with a dialysis bag (Mw=1000), and freeze-dried to obtain 4-arm-PEG-Br.
[0037] Synthesis of 4-arm-PEG-PMPC block copolymer: Weigh 4.3m...
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