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Preparation method and application of maltol magnetic molecularly imprinted solid-phase extraction material with core-shell micro-sphere structure

A technology of magnetic molecular imprinting and solid phase extraction materials, applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., can solve problems such as long equilibration time, difficult elution, deep embedding, etc. problem, to achieve low cost, avoid modification process, uniform thickness effect

Active Publication Date: 2019-05-10
CHINA TOBACCO ANHUI IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the imprinted sites of traditional imprinted polymers have disadvantages such as too deep embedding, difficult elution, and long equilibration time.

Method used

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  • Preparation method and application of maltol magnetic molecularly imprinted solid-phase extraction material with core-shell micro-sphere structure
  • Preparation method and application of maltol magnetic molecularly imprinted solid-phase extraction material with core-shell micro-sphere structure
  • Preparation method and application of maltol magnetic molecularly imprinted solid-phase extraction material with core-shell micro-sphere structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In this example, the preparation method of the maltol magnetic molecularly imprinted solid-phase extraction material with core-shell microsphere structure is as follows:

[0036] 1. Magnetic Fe 3 o 4 -Synthesis of COOH nanospheres

[0037] Accurately weigh 3.0g FeCl 3 ·6H 2 O. Put 0.83g sodium citrate dihydrate and 100mL ethylene glycol in a 250mL beaker, mechanically stir at 30°C until completely dissolved, add 4.80g anhydrous sodium acetate, 1500r min -1 Stir for 30 minutes, transfer the above mixed solution to the reaction kettle, heat at 200°C for 10h, and cool to room temperature naturally. Fe 3 o 4 -COOH nanospheres.

[0038] 2. Synthesis of pre-polymerized products

[0039] Dissolve 0.1mmol 3-hydroxy-2,6-bis(hydroxymethyl)-pyran-4-one and 1mL APTES in 10mL methanol, let stand at room temperature for 2h, and record it as polymerization solution a;

[0040] 3. Synthesis of Magnetic Virtual Template Molecularly Imprinted Microspheres

[0041] 200 mg of the m...

Embodiment 2

[0045] In this example, the preparation method of the maltol magnetic molecularly imprinted solid-phase extraction material with core-shell microsphere structure is as follows:

[0046] 1. Magnetic Fe 3 o 4 -Synthesis of COOH nanospheres

[0047] Accurately weigh 3.0g FeCl 3 ·6H 2 O. Put 0.83g sodium citrate dihydrate and 100mL ethylene glycol in a 250mL beaker, mechanically stir at 30°C until completely dissolved, add 4.80g anhydrous sodium acetate, 1500r min -1 Stir for 30 minutes, transfer the above mixed solution to the reaction kettle, heat at 200°C for 10h, and cool to room temperature naturally. Fe 3 o 4 -COOH nanospheres.

[0048] 2. Synthesis of pre-polymerized products

[0049] Dissolve 0.1mmol 3-hydroxy-2,6-bis(hydroxymethyl)-pyran-4-one and 1mL APTES in 10mL methanol, let stand at room temperature for 3h, and record it as polymerization solution a;

[0050] 3. Synthesis of Magnetic Virtual Template Molecularly Imprinted Microspheres

[0051] 200 mg of the...

Embodiment 3

[0055] In this example, the preparation method of the maltol magnetic molecularly imprinted solid-phase extraction material with core-shell microsphere structure is as follows:

[0056] 1. Magnetic Fe 3 o 4 -Synthesis of COOH nanospheres

[0057] Accurately weigh 3.0g FeCl 3 ·6H 2 O. Put 0.83g sodium citrate dihydrate and 100mL ethylene glycol in a 250mL beaker, mechanically stir at 30°C until completely dissolved, add 4.80g anhydrous sodium acetate, 1500r min -1 Stir for 30 minutes, transfer the above mixed solution to the reaction kettle, heat at 200°C for 10h, and cool to room temperature naturally. Fe 3 o 4 -COOH nanospheres.

[0058] 2. Synthesis of pre-polymerized products

[0059] Dissolve 0.1mmol 3-hydroxy-2,6-bis(hydroxymethyl)-pyran-4-one and 1mL APTES in 10mL methanol, let stand at room temperature for 3h, and record it as polymerization solution a;

[0060] 3. Synthesis of Magnetic Virtual Template Molecularly Imprinted Microspheres

[0061] 200 mg of the...

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Abstract

The invention discloses a preparation method and an application of a maltol magnetic molecularly imprinted solid-phase extraction material with a core-shell micro-sphere structure. 4-hydroxy-2, 5-dimethyl-3(2H)-furan serves as a virtual template molecule, and a magnetic molecularly imprinted polymer with the core-shell structure taking an Fe3O4-COOH magnetic nanosphere as a magnetic 'core' and taking a virtual template molecular imprinting as a 'shell' is prepared by an improved sol-gel method. The molecularly imprinted solid-phase extraction material is regular in shape, strong in magnetism and low in preparation cost, and has selective maltol adsorption performance and excellent interference resistance. The molecularly imprinted solid-phase extraction material serves as a magnetic solid-phase extraction material for separating, enriching and extracting maltol, is wide in application prospect, and has the advantages of less organic solvent usage, more simplicity and rapidness in operation, high efficiency and the like.

Description

technical field [0001] The invention relates to the preparation and application of a molecular imprinted solid phase extraction material, in particular to a preparation method and application of a maltol magnetic molecular imprinted solid phase extraction material with a core-shell microsphere structure. Background technique [0002] Maltol is an important food additive with a sweet caramel aroma. It is widely used in food, beverages and daily chemical products, and is also often used to improve the aroma and smoking quality of tobacco. However, excessive intake of these substances by the human body can cause dizziness, nausea, vomiting and dyspnea, and can even affect the functions of the liver and kidneys. Therefore, it is of great significance to separate, enrich and accurately evaluate the content of maltol in food. [0003] Molecularly imprinted polymers as solid-phase extraction fillers can specifically identify aroma compounds such as maltol, reduce interference from...

Claims

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Application Information

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IPC IPC(8): C08G83/00C08J9/28B01J20/281B01J20/28
Inventor 徐迎波刘少民朱栋梁黄兰付欣闫向阳彭晓萌
Owner CHINA TOBACCO ANHUI IND CO LTD
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