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Cream containing glycyrrhetinic acid and preparing method thereof

A technology of glycyrrhetinic acid and cream, applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of no glycyrrhetinic acid raw materials, recrystallization, anti-allergic and verification effects are not as good as glycyrrhetinic acid , to achieve high stability, prevent recrystallization, and high safety

Inactive Publication Date: 2019-05-14
西安博鸿生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since glycyrrhetinic acid is insoluble in water and oil, there is a risk of recrystallization in the emulsion
At present, there are few skin care products that use glycyrrhetinic acid, and glycyrrhizinate or glycyrrhetinic acid esters are mostly used, and their anti-allergic and proven effects are not as good as glycyrrhetinic acid.
At present, there is no pretreated raw material of glycyrrhetinic acid that can be used directly

Method used

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  • Cream containing glycyrrhetinic acid and preparing method thereof
  • Cream containing glycyrrhetinic acid and preparing method thereof
  • Cream containing glycyrrhetinic acid and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A kind of emulsion containing glycyrrhetinic acid of the present embodiment, by weight, comprises following composition successively:

[0050] Oil phase:

[0051] Sorbitan Olivate 0.5-3.0%

[0052] Cetearyl Glucoside 0.5-3.0%

[0053] Cetearyl Alcohol 2.0-6.0%

[0054] Beeswax 1.0-3.0%

[0055] Shea Butter 1.0-5.0%

[0056] Hydrogenated polyisobutylene 1.0-4.0%

[0057] Simethicone 2.0-5.0%

[0058] Cyclopentasiloxane 1.0-3.0%

[0059] Caprylic / Capric Triglyceride 2.0-8.0%

[0060] water box:

[0061] Water 60-80%

[0062] Polyol 0-5.0%

[0063] Allantoin 0.2-0.6%

[0064] Methylparaben 0.1-0.2%

[0065] Xanthan gum 0.01-0.2%

[0066] Low temperature phase 1:

[0067] Polyol 1.0-6.0%

[0068] Glycyrrhetinic acid 0.1-0.5%

[0069] Low temperature phase 2:

[0070] Panthenol 0.1-1.5%

[0071] Polygonum extract 0.01-0.1%

[0072] Phenoxyethanol 0.5-0.8%

[0073] Ethylhexylglycerin 0.05-0.1%

[0074]A cream containing glycyrrhetinic acid in this embodim...

Embodiment 2

[0076] In this embodiment, on the basis of Example 1, the polyol can be one or more of ethanol, glycerin, propylene glycol, butanediol, and 1,2-pentanediol, and the ethanol is dealdehyde alcohol, or denatured ethanol.

Embodiment 3

[0078] In this embodiment, on the basis of Examples 1-2, as a preferred embodiment, an emulsion containing glycyrrhetinic acid, in parts by weight, includes the following ingredients in turn:

[0079] Oil phase:

[0080] Sorbitan Olivate 2.0%

[0081] Cetearyl Glucoside 1.5%

[0082] Cetearyl Alcohol 4.0%

[0083] Beeswax 2.0%

[0084] Shea Butter 2.0%

[0085] Hydrogenated Polyisobutylene 2.0%

[0086] Simethicone 4.0%

[0087] Cyclopentasiloxane 1.5%

[0088] Caprylic / Capric Triglyceride 5.0%

[0089] water box:

[0090] Water 66.33%

[0091] Glycerin 2.0%

[0092] Butanediol 2.0%

[0093] Allantoin 0.3%

[0094] Methylparaben 0.15%

[0095] Xanthan Gum 0.1%

[0096] Low temperature phase 1:

[0097] Ethanol 2.0%

[0098] Glycyrrhetinic Acid 0.2%

[0099] Low temperature phase 2:

[0100] Panthenol 1.0%

[0101] Polygonum extract 0.02%

[0102] Phenoxyethanol 0.72%

[0103] Ethylhexylglycerin 0.08%

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Abstract

The invention belongs to the technical field of fine chemical engineering, and relates to a cream containing glycyrrhetinic acid and a preparing method thereof. The cream includes a water phase, an oil phase, a first low-temperature phase and a second low-temperature phase, wherein the first low-temperature phase contains the glycyrrhetinic acid. The preparing method comprises the steps of heatingthe water phase and the oil phase to 75-80 DEG C separately, conducting gradient homogenization to obtain an O / W emulsion, preprocessing the first low-temperature phase, dissolving or evenly dispersing the glycyrrhetinic acid with polyhydric alcohols, adding the mixture at 46-65 DEG C, and adding the second low-temperature phase at 42-45 DEG C. The cream containing the glycyrrhetinic acid is highin safety and good in effect, and can be used for nursing inflammation and then sensitive skin. By the adoption of the preparing method, the O / W emulsion obtained after gradient homogenization of thewater phase and the oil phase is smaller and more even in particle size, and is higher in stability after solidifying into plaster; the glycyrrhetinic acid is preprocessed, so that the glycyrrhetinicacid disperses more evenly and is capable of being effectively prevented from recrystallizing in the cream, and thus the cream can better work.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and relates to a skin care product and a preparation method thereof, in particular to a cream containing glycyrrhetinic acid and a preparation method thereof. Background technique [0002] The chemical structure of glycyrrhetinic acid is similar to steroid hormones, and it is an inhibitor of steroid hormone metabolic inactivation enzyme 11β-hydroxysteroid dehydrogenase. Glycyrrhetinic acid-related inhibition of 11β-hydroxysteroid dehydrogenase activity, regulation of glucocorticoids into the target cell corticosteroid receptors, can improve the activity of endogenous and exogenous glucocorticoids, and can also be used as a ligand and Glucocorticoid receptor binding, since the glucocorticoid receptor agonistic activity of glycyrrhetinic acid is much lower than that of glucocorticoids, it is a partial agonistic antagonist of glucocorticoid receptors. Glycyrrhetinic acid can be used clinical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/63A61K8/92A61K8/49A61K8/34A61K8/42A61K8/06A61Q19/00A61P17/00A61P17/04A61P37/08
Inventor 李丹
Owner 西安博鸿生物技术有限公司
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