Solution preparation for aerosol inhalation of ginkgo dew and preparing method of solution preparation

An atomized inhalation and ginkgo dew technology, applied in the field of pharmaceuticals, can solve the problems of no atomized inhalation solution dosage form, no standardized use method, hidden safety hazards in use, etc., and achieve rapid onset, anti-asthma effect, and low dosage Effect

Inactive Publication Date: 2019-05-14
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no special spray inhalation solution dosage form in all clinical applications at present, and there is no standardized method of use, and there are potential safety hazards in use.

Method used

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  • Solution preparation for aerosol inhalation of ginkgo dew and preparing method of solution preparation
  • Solution preparation for aerosol inhalation of ginkgo dew and preparing method of solution preparation
  • Solution preparation for aerosol inhalation of ginkgo dew and preparing method of solution preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of ginkgo dew atomized inhalation solution:

[0045]

[0046] (1) Preparation of ginkgo kernel extract:

[0047] Take ginkgo kernel by prescription quantity, ginkgo kernel is broken into pieces, according to the percolation method (Chinese Pharmacopoeia 2005 edition an appendix I0) under liquid extract and extract item, make solvent with 7 times of amount 60% ethanol, carry out Percolation, the filtrate recovers ethanol and concentrates it into a clear paste with a relative density of 1.02-1.07 (55-65°C), stands still, separates, filters, and the filtrate is set aside.

[0048] (2) The preparation of the extract of Chinese herbal medicine:

[0049] Weigh 蔊菜 according to the prescription amount, add 10 times the amount of water to extract for 2 hours, filter, add 8 times the amount of water to extract for 2 hours, filter, combine the filtrate, concentrate the filtrate into a clear paste (each 1ml is equivalent to 2g of medicinal materials), cool Then add...

Embodiment 2

[0053] Preparation of ginkgo dew atomized inhalation solution:

[0054]

[0055] (1) Preparation of ginkgo kernel extract:

[0056] Take ginkgo kernel by prescription quantity, ginkgo kernel is broken into pieces, according to the percolation method (Chinese Pharmacopoeia 2005 edition an appendix I0) under liquid extract and extract item, make solvent with 7 times of amount 60% ethanol, carry out Percolation, the filtrate recovers ethanol and concentrates it into a clear paste with a relative density of 1.02-1.07 (55-65°C), stands still, separates, filters, and the filtrate is set aside.

[0057] (2) The preparation of the extract of Chinese herbal medicine:

[0058] Weigh 蔊菜 according to the prescription amount, add 10 times the amount of water to extract for 2 hours, filter, add 8 times the amount of water to extract for 2 hours, filter, combine the filtrate, concentrate the filtrate into a clear paste (each 1ml is equivalent to 2g of medicinal materials), cool Then add...

Embodiment 3

[0062] Preparation of ginkgo dew atomized inhalation solution:

[0063]

[0064] (1) Preparation of ginkgo kernel extract:

[0065] Take ginkgo kernel by prescription quantity, ginkgo kernel is broken into pieces, according to the percolation method (Chinese Pharmacopoeia 2005 edition an appendix I0) under liquid extract and extract item, make solvent with 7 times of amount 60% ethanol, carry out Percolation, the filtrate recovers ethanol and concentrates it into a clear paste with a relative density of 1.02-1.07 (55-65°C), stands still, separates, filters, and the filtrate is set aside.

[0066] (2) The preparation of the extract of Chinese herbal medicine:

[0067] Weigh 蔊菜 according to the prescription amount, add 10 times the amount of water to extract for 2 hours, filter, add 8 times the amount of water to extract for 2 hours, filter, combine the filtrate, concentrate the filtrate into a clear paste (each 1ml is equivalent to 2g of medicinal materials), cool Then add...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a solution preparation for aerosol inhalation of ginkgo dew and a preparing method of the solution preparation. The solution preparation is prepared from effective ginkgo dew components, an isosmotic agent and a solvent. The effective ginkgo dew components include a ginkgo seed extract solutionand an indian rorippa herb extract solution. Each liter of the solution for aerosol inhalation comprises the ginkgo seed extract solution prepared from 40-500 g of ginkgo seeds and the indian rorippaherb extract solution prepared from 70-750 g of indian rorippa herbs. According to the solution for aerosol inhalation of the ginkgo dew, aerosol can be quickly formed through an atomizer, and can directly and quickly act on a wound, and drugs acting on the wound can be quickly absorbed to take effect. The solution preparation is small in dosage, takes effect quickly, has a good curative effect,and has no other toxic or side effects.

Description

technical field [0001] The invention relates to a ginkgo dew solution preparation for atomized inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Cough is a common symptom of the respiratory tract. It is caused by inflammation, foreign bodies, physical or chemical stimulation of the trachea, bronchial mucosa or pleura. The air inside is jetted out. Usually accompanied by sound. Coughing has a protective effect of clearing foreign bodies and secretions from the respiratory tract. However, if the cough persists and turns from acute to chronic, it often brings greater pain to the patient, such as chest tightness, itchy throat, and panting, often accompanied by expectoration. Prolonged and severe cough will affect rest, and it is easy to consume physical strength, and can cause damage to the elastic tissue of the alveolar wall, and induce emphysema. [0003] "Chinese Pharmacopoeia (2015 Edition)" records: Ginkgo ker...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61K9/72A61K47/02A61K47/26A61P11/14A61P11/10A61P11/06A61K36/16
Inventor 张保献胡杰
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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