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Application of araboxylan sulfonate to preparation of medicine for treating osteoarthritis

A technology of xylan sulfonate and arabinoxylan, applied in the direction of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems that there is no arabinoxylan sulfonate, etc., to improve the curative effect, sulfonate The effect of high chemical efficiency and avoiding the burden of environmental pollution

Active Publication Date: 2019-05-24
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report about the application of arabinoxylan sulfonate in the preparation of drugs for the treatment of osteoarthritis

Method used

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  • Application of araboxylan sulfonate to preparation of medicine for treating osteoarthritis
  • Application of araboxylan sulfonate to preparation of medicine for treating osteoarthritis
  • Application of araboxylan sulfonate to preparation of medicine for treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Effects of different administration methods on the treatment of rabbit knee arthritis and comparison with commercially available drugs

[0068] Osteoarthritis is a chronic, progressive, degenerative joint disease, clinically characterized by joint pain, deformation, and limited mobility, pathologically manifested as articular cartilage softening, fibrosis, ulceration, cartilage loss, and hardening of subchondral bone , Subchondral bone cyst, etc. The way of administration has an important influence on the efficacy of the drug. In this experiment, the effects of oral and subcutaneous injection of arabinoxylan sulfonate on the treatment of arthritis were investigated through different ways of administration, and the commercially available oral drug combination (celecoxib and glucosamine sulfate) were compared with sodium arabinoxylan sulfonate.

[0069] 1. Materials

[0070] 1.1. Test animals

[0071] 40 adult New Zealand white rabbits, weighing 2.8±0.2kg, h...

Embodiment 2

[0147] Example 2 Effects of different plant sources and different structures of xylan sulfonate on rabbit knee arthritis Although almost all terrestrial plant cell walls contain various types of xylan, the structure of xylan itself is different However, it is extremely significant, even completely different. Therefore, the purpose of this embodiment is to study the effects of different plant sources and structural differences of xylan sulfonate on the treatment of rabbit osteoarthritis, and to illustrate the relationship between different polymer structures in raw materials and their therapeutic effects. relation.

[0148] 1. Materials

[0149] 1.1. Test animals

[0150] 40 adult New Zealand white rabbits, weighing 2.8±0.2kg, half male and half male, were reared in separate cages and divided into 5 groups on average, namely:

[0151] A: normal blank group

[0152] B: model group

[0153] C: Sample 1 administration group

[0154] D: Sample 2 drug administration group

[0...

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Abstract

The invention discloses an application of araboxylan sulfonate to preparation of a medicine for treating osteoarthritis, and belongs to the technical field of medicines. According to a large number ofstudies, the araboxylan sulfonate has very obvious osteoarthritis treating functions, inflammation can be eliminated, cartilage repair can be promoted, and illness states can be reversed to a certaindegree, so that the araboxylan sulfonate can be used for preparing the medicine for treating the osteoarthritis.

Description

technical field [0001] The invention relates to the application of arabinoxylan sulfonate in the preparation of medicines for treating osteoarthritis, belonging to the technical field of medicines. Background technique [0002] Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage, and its main clinical manifestations are slowly developing joint pain, stiffness, swelling and limited mobility. The prevalence of OA in our country is as high as 50% in people over 60 years old, and 80% in people over 75 years old. This disease has become one of the most common diseases that seriously affect the quality of life of the elderly. [0003] At present, the treatment of OA mainly includes oral medicine, intra-articular injection of medicine and surgical treatment. Among them, intra-articular injection belongs to puncture, which requires high operation and is not easy to be used repeatedly. It is mainly aimed at relieving symptoms and improving the condition of m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P19/08A61P19/02A61P29/00
CPCA61K31/715A61P19/02A61P19/08A61P29/00
Inventor 王磊张厚瑞陈海珊
Owner GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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