A kind of anti-adhesion material containing white and polysaccharide and preparation method thereof

An anti-adhesion and anti-adhesion film technology, which is applied in the field of biomedical materials, can solve the problems of short material activity retention time, achieve good biocompatibility, prevent tissue adhesion, and have good clinical application prospects

Active Publication Date: 2021-07-30
北京颐方生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Medical chitosan film is used for anti-adhesion, liquid and easy-flowing substances, affected by changes in the patient's position, has a lubricating effect, and the retention time of material activity is short

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The anti-adhesion material containing white and polysaccharide is a biofilm made of 60 parts by weight of white and polysaccharide, 60 parts by weight of hydroxypropyl cellulose and 0.6 part by weight of BDDE.

[0039] The preparation method comprises: respectively dissolving the polysaccharide and hydroxypropyl cellulose in deionized water to prepare a solution of polysaccharide with a concentration of 0.5% (w / w) and a solution of hydroxypropyl cellulose with a concentration of 0.5% (w / w). Base cellulose solution; mix the two evenly, adjust the pH to 10.5 with sodium hydroxide; add BDDE according to the proportion, stir evenly (stirring for at least 10-30min) to make a mixed solution; pass through a 300 mesh sieve, degas under reduced pressure, and store at room temperature Cast film after standing.

Embodiment 2

[0041] The anti-adhesion material comprising white and polysaccharide is a biofilm made of 30 parts by weight of white and polysaccharide, 20 parts by weight of hydroxyethyl cellulose and 2 parts by weight of BDDE.

[0042] The only difference between the preparation method and Example 1 is that the concentration of the prepared white polysaccharide solution is 2% (w / w), the concentration of the hydroxyethyl cellulose solution is 1.25% (w / w), and the pH is 10.8.

Embodiment 3

[0044] The anti-adhesion material comprising white and polysaccharide is a biofilm made of 30 parts by weight of white and polysaccharide, 20 parts by weight of hydroxymethyl cellulose and 2 parts by weight of BDDE.

[0045] The only difference between the preparation method and Example 1 is that the concentration of the prepared white and polysaccharide solution is 5% (w / w), the concentration of the hydroxymethyl cellulose solution is 2.9% (w / w), and the pH is 11.0.

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PUM

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Abstract

The invention relates to an anti-adhesion material containing white polysaccharide and a preparation method thereof. The anti-adhesion material is that BDDE is added to the mixed solution of white polysaccharide and hydroxyalkyl cellulose under alkaline conditions to form an absorbable anti-adhesion material, which can be prepared into anti-adhesion sponge, anti-adhesion film and anti-adhesion gel. The complex prepared by the chemical reaction of white and polysaccharide, hydroxyalkylcellulose and BDDE can be used for anti-adhesion in pelvic cavity, abdominal cavity, etc., and has hemostatic and healing-promoting functions, and has excellent biological safety and convenient operation. Strong, with good clinical application prospects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a degradable anti-adhesion material that directly acts on bloody wounds such as humans and mammals and has the functions of stopping bleeding and promoting wound healing and a preparation method thereof. Background technique [0002] Tissue adhesions are prone to occur after surgery. Adhesions are abnormal structures in which fibrous bands of connective tissue join together with adjacent tissues or organs and can range in extent from a thin film to dense vascular scar tissue. Postoperative adhesion is not only a common clinical phenomenon in the field of surgery, but also a pathophysiological process that must occur in the postoperative healing process. According to statistics, the incidence of postoperative adhesions is as high as 90%. Among them, 10% of the adhesions cause a series of complications for the patient, leading to a decline in the quality of life of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 石清东王姣王正元
Owner 北京颐方生物科技有限公司
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