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A kind of multi-block polyethylene glycol containing hydroxyl group and active double bond and preparation method thereof

A technology of polyethylene glycol and polyethylene glycol diacrylate, which is applied in the field of polymer preparation, can solve the problems of few surface groups, inability to achieve better loading capacity, etc., and achieves good stability and small immunogenicity. and antigenicity and low toxicity

Active Publication Date: 2021-07-30
WENZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the main components of the drug cannot directly enter the human body. When entering the human body, it is decomposed by body fluids such as gastric juice and digestive juice. It often needs to be loaded by a carrier. The carrier generally needs better loading performance, and polymer materials are often used. However, polymer materials have few surface groups after polymerization, so they cannot achieve better loading capacity.

Method used

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  • A kind of multi-block polyethylene glycol containing hydroxyl group and active double bond and preparation method thereof
  • A kind of multi-block polyethylene glycol containing hydroxyl group and active double bond and preparation method thereof
  • A kind of multi-block polyethylene glycol containing hydroxyl group and active double bond and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] 10g (0.025mol) polyethylene glycol diacrylate (Mn=400), 5g (0.025mol) glutaraldehyde 50% aqueous solution, 0.28g (0.0025mol) 1,4-diazide bicyclo [2.2.2] octane Alkane (DABCO) catalyst, 0.014g p-hydroxyphenol polymerization inhibitor, 50mL acetone as solvent, after heating to reflux for 96 hours, distill off the solvent under reduced pressure, add dichloromethane, and dry with anhydrous magnesium sulfate for 24 hours, filter, and the filtrate passes through Dichloromethane was distilled off under reduced pressure, and the crude product was precipitated with ether to obtain multi-block polyethylene glycol containing hydroxyl groups and active double bonds. Mn(GPC)=4500, PDI(GPC)=1.8

Embodiment 2

[0037] 10g (0.01) polyethylene glycol diacrylate (Mn=1000), 2g (0.01mol) glutaraldehyde 50% aqueous solution, 0.12g (0.001mol) 1,4-diazide bicyclo [2.2.2] octane (DABCO) catalyst, 0.01g p-hydroxyphenol polymerization inhibitor, 50mL acetone as solvent, after heating and refluxing for 96 hours, the solvent was distilled off under reduced pressure, dichloromethane was added, and when drying with anhydrous magnesium sulfate for 24 hours, filter, and the filtrate was passed through Dichloromethane was distilled off under high pressure, and the crude product was precipitated with ether to obtain multi-block polyethylene glycol containing hydroxyl groups and active double bonds. Mn(GPC)=7200, PDI(GPC)=2.0

[0038]

Embodiment 3

[0040] 10g (0.025mol) polyethylene glycol diacrylate (Mn=400), 3.35g (0.025mol) terephthalaldehyde, 0.28g (0.0025mol) 1,4-diazidebicyclo[2.2.2]octane (DABCO) catalyst, 0.014g p-hydroxyphenol polymerization inhibitor, 50mL acetone as solvent, after heating and refluxing for 96 hours, the solvent was distilled off under reduced pressure, dichloromethane was added, and when drying with anhydrous magnesium sulfate for 24 hours, filter, and the filtrate was filtered by reducing Dichloromethane was distilled off under high pressure, and the crude product was precipitated with ether to obtain multi-block polyethylene glycol containing hydroxyl groups and active double bonds. Mn(GPC)=5300, PDI(GPC)=1.8

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Abstract

The invention discloses a method for preparing multi-block polyethylene glycol containing active hydroxyl groups and double bonds. The method uses polyethylene glycol diacrylate and dialdehyde compounds as raw materials, and undergoes Baylis-Hillman reaction to obtain multi-block polyethylene glycol containing hydroxyl groups and active double bonds. The multi-block polyethylene glycol can be cross-linked by free radicals under ultraviolet light irradiation to prepare polyethylene glycol-based hydrogel.

Description

technical field [0001] The invention relates to the field of polymer preparation, in particular to a multi-block polyethylene glycol containing hydroxyl groups and active double bonds. Background technique [0002] Drugs are substances used to prevent, treat and diagnose disease. In theory, drugs refer to all chemical substances that can affect the physiological functions of the body's organs and cell metabolism activities, including contraceptives and health care drugs. [0003] In the prior art, the main components of the drug cannot directly enter the human body. When entering the human body, it is decomposed by body fluids such as gastric juice and digestive juice. It often needs to be loaded by a carrier. The carrier generally needs better loading performance, and polymer materials are often used. However, polymer materials have few surface groups after polymerization, so they cannot achieve better loading capacity. Contents of the invention [0004] Aiming at the d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/331A61K47/60
Inventor 李钟玉单鹏飞余潘晨赵聪
Owner WENZHOU UNIV