Preparation method of salidroside

A technology of salidroside and rhodiola, which is applied in the field of preparation of salidroside, can solve the problems of low purity of salidroside and low extraction rate of salidroside, and improve the anti-fatigue effect and practicability Excellent, guaranteed medical value effect

Inactive Publication Date: 2019-06-25
广州翰江生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing methods all have the defects of low extraction rate of salidroside extracted from Rhodiola rosea and low purity of salidroside extracted.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The preparation method of salidroside includes:

[0031] S1: Remove the rhodiola rhizome soil, use a medicine washing machine to clean the rhodiola rhizome, wash and dry;

[0032] S2: Crush the rhodiola rhizome, add 10-20 times the weight of the buffer solution, adjust the pH to 4-5, and the temperature to 45-55℃, then add 0.05-0.1% of the weight of rhodiola with biological enzymes, enzymatic hydrolysis 1.5 -3 hours to obtain the enzymatic hydrolysate;

[0033] S3: Inactivate the enzyme hydrolysate, filter, collect the filtrate, concentrate the filtrate to 1 / 4- 1 / 2 of the original volume of the filtrate, spray dry, and obtain a crude salidroside extract;

[0034] S4: Add 80% ethanol 15-20 times the weight of the enzymatically extracted powder to the crude salidroside extract, and perform reflux extraction in a water bath at 70°C for 2 hours, and then repeat the extraction three times, 1.5 each time h, make an alcohol extract;

[0035] S5: Add hydrochloric acid to the inside of ...

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PUM

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Abstract

The invention discloses a preparation method of salidroside. The preparation method comprises removing rhizome soil of the salidroside, washing and drying; pulverizing the rhizome of the salidroside,adding a buffer solution and conducting enzymatic hydrolysis with biological enzyme to obtain an enzymatic hydrolysate; conducting enzyme deactivation, filtering, collecting a filtrate and conductingspraying and drying to obtain a salidroside crude extract; adding ethanol to the salidroside crude extract to prepare an ethanol extract; adding hydrochloric acid to the ethanol extract, stirring andheating to prepare a preliminary extraction solution; centrifuging the preliminary extraction solution, removing a precipitate, taking a supernatant and applying static pressure at room temperature toobtain a high pressure extraction solution; extracting the high pressure extraction solution repeatedly, adding a macroporous adsorption resin material, eluting with ethanol to obtain a purified solution; concentrating the purified solution, conducting evaporation crystallization and pulverizing to obtain a salidroside powder product. The compound enzyme is utilized to hydrolyze the salidroside,maximize the dissolution of the salidroside, ensure the extraction rate and improve the purity of the salidroside.

Description

Technical field [0001] The present invention relates to the technical field of medicine extraction, in particular to a preparation method of salidroside. Background technique [0002] Rhodiola (scientific name: Rhodiola rosea L.), aliases: Rhodiola rosea, Saul Mabul (Tibetan name), etc.; it is a perennial herb, 10-20 cm high. The roots are strong, conical, fleshy, brownish-yellow, with many fibrous roots on the neck of the root, short, thick, cylindrical, and many scale-like leaves arranged in tile-like shapes. It grows in the high and cold pollution-free zone at an altitude of 1800-2500 meters, and its growth environment is harsh, so it has strong vitality and special adaptability. It can be used for medicinal purposes. It can nourish qi and clear the lungs, nourish the mind and nourish the heart. It is a traditional Chinese medicine with a wide range of effects. It also has a great beauty effect, can be used as skin care products, and can also be eaten. [0003] Natural plant ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08
Inventor 宋锡明
Owner 广州翰江生物科技有限公司
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