Functionalized micro-channel plate and biomolecular sensor including same

A microchannel plate and functionalization technology, applied to laboratory containers, chemical instruments and methods, laboratory utensils, etc., can solve the complex preparation process, lack of specific signal enhancement of biomolecules, and inability to effectively enhance markers Raman spectroscopy and other issues, to achieve the effect of simple preparation process, enhanced signal amplification effect, and enhanced Raman effect

Pending Publication Date: 2019-06-28
ZIGONG INNOVATION CENT OF ZHEJIANG UNIV
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Problems solved by technology

[0007] At present, the microchannel plates used in biosensors in other patents are based on the principle of secondary electron multiplication for signal amplification. At this time, the microchannel plates need to use lead-containing glass and be reduced in a hydrogen atmosphere. Not only is the preparation process complicated, but Moreover, it cannot effectively enhance the Raman spectrum of the marker, and lacks the enhancement of the specific signal of biomolecules

Method used

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  • Functionalized micro-channel plate and biomolecular sensor including same
  • Functionalized micro-channel plate and biomolecular sensor including same
  • Functionalized micro-channel plate and biomolecular sensor including same

Examples

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Embodiment 1

[0026] Embodiment 1: as figure 1 ‐3,

[0027] A microchannel plate. The microchannel plate is arranged with a plurality of inclined vertically transparent microholes 1, and an array of metal nanorods 2 is attached to the microholes 1. The material of the metal nanorods 2 is silver.

[0028] The diameter of the metal nanorod 2 in the metal nanorod array is 60nm, the length is 130nm, and the density of the metal nanorod array is 10 4 / μm 2 , the shape of metal nanorod 2 is clear.

[0029] The metal nanorod 2 array uses a microchannel plate as a growth substrate, and its inherent inclination angle (the angle between the wall of the microwell 1 and the horizontal line is greater than 70°) has a shadow effect on the growth of nanostructures during the metal deposition process. In the early stage of deposition, the metal nucleates to form an island structure; in the later stage of growth, because the high parts intercept the supply of metal vapor, the growth of its adjacent parts...

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Abstract

The invention relates to a functionalized micro-channel plate. The functionalized micro-channel plate is characterized in that a plurality of oblique up-down transparent micro-holes parallel to one another are arrayed in the micro-channel plate, and metal nanorod arrays are attached to the insides of the micro-holes. A biomolecular sensor is characterized by comprising a signal amplification device, an energy conversion device and a recognition device, wherein the signal amplification device is used for realizing the concentration detection of trace markers (concentration: -fg/mL) and even single molecules by virtue of the micro-channel plate; and the metal nanorod arrays are prepared in the micro-channel plate, and biological markers are detected by virtue of a Raman spectrum based on surface plasmon resonance of the metal nanorod arrays in the micro-holes of the micro-channel plate.

Description

technical field [0001] The invention relates to a functionalized microchannel plate and a biomolecule sensor comprising the microchannel plate. Background technique [0002] Biomolecules are the material bearers of human physiological activities, as well as the prediction and diagnosis of diseases and the carriers of information. Detecting the concentration of specific biomolecules (such as nucleic acids, proteins, viruses, etc., hereinafter collectively referred to as markers) in biological samples (including blood, saliva, urine, etc.) Chemotherapy is very important. Substances that can selectively distinguish specific substances in living organisms include enzymes, antibodies, tissues, cells, and the like. These molecular recognition functional substances can be combined with the measured target to form complexes through the recognition process, such as the combination of antibodies and antigens, and the combination of enzymes and substrates. [0003] In order to bette...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00C23C14/24C23C14/14C23C14/34C23C14/02B82Y40/00G01N21/65
Inventor 张兴业曹臻杨彦彬
Owner ZIGONG INNOVATION CENT OF ZHEJIANG UNIV
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