A kind of processing method of the sodium phenylacetate deesterification liquid that penicillin g potassium salt crystallization mother liquor pyrolysis produces

Abstract

The invention provides a disposal method of sodium phenylacetate deesterification liquid generated by cracking a penicillin G potassium salt crystallization mother liquor and belongs to the technicalfield of pharmaceutical wastewater disposal. The method comprises the steps of mixing a sodium phenylacetate deesterification liquid and active carbon, removing a penicillin degradation product, and conducting filtering to obtain a predisposed sodium phenylacetate deesterification liquid; carrying out primary dialysis on the predisposed sodium phenylacetate deesterification liquid to obtain a primary dialysate and a primary concentrated liquid, wherein the cut-off molecular weight of a dialysis membrane used for the primary dialysis is 6,000-10,000 Da; performing secondary dialysis on the primary dialysate to obtain a secondary dialysate and a secondary concentrated liquid, wherein the cut-off molecular weight of a dialysis membrane used for secondary dialysis is 1,000-4,000 Da; concentrating the secondary dialysate and returning the secondary dialysate to a penicillin fermentation working section. According to the disposal method, there is no need to add hydrogen peroxide or conduct crystallization and crystallization remelting, the amount of generated waste liquid is small, and the energy consumption is low.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical wastewater treatment, in particular to a method for treating sodium phenylacetate deesterified liquid produced by cracking penicillin G potassium salt crystallization mother liquor. Background technique [0002] At present, the penicillin G potassium salt crystallization mother liquor treatment process is: add penicillin lyase, penicillin G potassium salt is cracked into 6-aminopenicillanic acid (i.e. 6-APA) and phenylacetic acid, after phenylacetic acid is extracted by butyl acetate, Use sodium hydroxide to adjust the pH value to 9-10.5, convert phenylacetic acid into sodium phenylacetate, and then distill under normal pressure at 100-110°C to obtain sodium phenylacetate deesterification liquid, and then use 10% hydrogen peroxide and 3‰ activated carbon to decolorize , and then return to the penicillin fermentation section after evaporative crystallization and crystal remelting. The treat...

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Problems solved by technology

The treatment process of the sodium phenylacetate deesterification liquid in the above process requires a large amount of activated carbon and hydrogen peroxide, resulting in high operating costs, and the mother liquor after crystallization of sodium phenylacetate cannot be discharged directly because of its strong taste, but can only be incinerated, and has an overall process Disadvantages of complicated, waste liquid and waste

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