Contact pressure interference suppression method, device and measurement method in diffuse reflection measurement
A contact pressure and diffuse reflection technology, applied in the field of spectral detection, can solve the problems that the contact pressure signal cannot truly reflect the contact pressure value, increase the complexity of the experimental operation, etc., and achieve reliable measurement results, high signal-to-noise ratio, and good data stability. Effect
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no. 1 example
[0060] First, the Monte Carlo simulation test is explained, such as figure 2 As shown, as the first embodiment, the MonteCarlo simulation test includes the following steps:
[0061] Step 101a: Establish a three-layer skin tissue model, and obtain tissue optical parameters and tissue mechanical parameters required for Monte Carlo simulation.
[0062] Monte Carlo simulation is a statistical method mainly used to deal with the problem of particle transport in various media under different conditions, and it is also the most effective and accurate random statistical method for dealing with photon transport in skin tissue. For biological tissue, Monte Carlo simulation calculates each tiny computing unit by establishing a random process or probability model corresponding to photon incident skin tissue, and uses statistical methods to obtain statistical characteristics of parameters as numerical solutions.
[0063] When the optical parameters and boundary conditions of the skin tis...
no. 2 example
[0099] As a second embodiment, a method and apparatus for suppressing contact pressure interference in diffuse reflectance measurement in an actual in vivo test are provided. First, a contact pressure interference suppression device in diffuse reflection measurement is built to measure the diffuse reflection light intensity of human skin tissue at different radial positions under different contact pressures, and thus obtain the diameter when the change of the diffuse reflection light intensity value is 0. to position;
[0100] like Figure 4 As shown, the contact pressure interference suppression device includes:
[0101] A light source; an optical fiber for transmission of light; a fiber optic probe, comprising: an incident optical fiber for outputting light from the light source to an object to be measured; and a plurality of outgoing optical fibers having one or more radial positions relative to the incident optical fiber, for Receive the diffuse reflection light of the m...
no. 3 example
[0128]It can be seen from the second embodiment that the predicted value of blood glucose concentration and the measured value of blood glucose concentration predicted by combining the spectral data of the pressure-insensitive position and PLSR modeling are basically consistent. Therefore, the diffuse reflectance spectral measurement based on the pressure-insensitive position can To a certain extent, the interference of contact pressure changes in volume measurement is reduced.
[0129] As a third embodiment, a diffuse reflectance spectroscopy measurement method is proposed by combining the spectral data of pressure-insensitive locations and PLSR modeling, such as Figure 10 As shown, the method includes:
[0130] Step 201: Perform pressure interference suppression processing according to the contact pressure interference suppression method in the above-mentioned embodiment;
[0131] Step 202: Acquire the diffuse reflectance spectrum data at the pressure-insensitive position ...
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