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Skin-care compound and preparation method and application thereof, and skin-care product

A compound and skin care product technology, applied in the field of skin care compounds and their preparation, can solve the problems of skin dermis elastic fiber degeneration and the like

Active Publication Date: 2019-08-09
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of hydroquinone may cause tan and skin dermal elastosis

Method used

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  • Skin-care compound and preparation method and application thereof, and skin-care product
  • Skin-care compound and preparation method and application thereof, and skin-care product
  • Skin-care compound and preparation method and application thereof, and skin-care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] This embodiment provides a skin care compound, which can be used to prepare skin care products; wherein, the skin care compound is (1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4, 6-heptatrien-3-one; its structural formula is:

[0038]

[0039] The skin care compound of this example is a yellow amorphous solid; the melting point is 168-170°C.

[0040] The nuclear magnetic resonance spectrum of the skin care compound of the present embodiment is:

[0041] 1 H NMR (500MHz, CD 3 COCD 3)δ7.57(1H,d,J=15.8Hz,H-1),7.56(2H,d,J=8.6Hz,H-2',6'),7.49(1H,dd,J=15.3,10.6 Hz,H-5),7.42(2H,d,J=8.6Hz,H-2",6"),7.02(1H,d,J=15.8Hz,H-2),6.98(1H,d,J =15.3Hz, H-7), 6.93(1H, dd, J=15.3, 10.6Hz, H-6), 6.86(2H, d, J=8.6Hz, H-3', 5'), 6.82(2H ,d,J=8.6Hz,H-3",5"),6.59(1H,d,J=15.3Hz,H-4);

[0042] 13 C NMR (125MHz, CD 3 COCD 3 )δ188.7(C-3), 160.7(C-4'), 159.6(C-4"), 144.0(C-5), 142.9(C-1), 142.0(C-7), 131.2(C -2',6'),129.9(C-2",6"),129.2(C-4),129.1(C-1'),127.7(C-1"),125.4(C-6),123.6 (C-2), 116...

Embodiment 2

[0045] For the skin care compound in Example 1, this example proposes a new preparation method, that is, to obtain the skin care compound in Example 1 by separating it from natural plants. Preferably, this example isolates the skin care compound (1E,4E,6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptanetri in Example 1 from the purple ginger plant en-3-ones.

[0046] Purple ginger, also known as Zingiber cassumunar Roxb, is a plant of the genus Zingiber in the Zingiberaceae family and is cultivated in southern and southeastern Yunnan. It is distributed or cultivated in India, Sri Lanka, Cambodia, and South Asia. Purple ginger is pungent, slightly bitter, and warm. Go into liver, stomach, kidney channel. It has the effects of invigorating the stomach and eliminating food, ventilating and relieving pain, eliminating wind and detoxification, promoting blood circulation and reducing swelling, promoting gallbladder and reducing jaundice. Used for distending pain in the epigastric cavity...

Embodiment 3

[0062] In this example, the preparation method of the skin care product provided in Example 2 is used to separate the skin care compound from the purple ginger plant, and the specific steps are as follows:

[0063] Select 4 kg of purple ginger tubers dried in the shade, cold soak and extract them with 65% ethanol-water solution for 3 times, each time for 24 hours, and finally combine the extracts to obtain the purple ginger extract. Carry out rotary evaporation and concentration treatment on the purple ginger extract until only the water liquid remains, extract with petroleum ether, extract 3 times, and extract the remaining water phase part with chloroform three times, and then use ethyl acetate to extract the water phase part after chloroform extraction Extraction was performed three times to obtain 10.9 g of ethyl acetate extract (ie, purple ginger extract after preliminary purification). The ethyl acetate extract was subjected to silica gel column chromatography, and gradi...

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Abstract

The invention relates to a skin-care compound and a preparation method and application thereof, and a skin-care product, and relates to the technical field of skin-care products. According to the technical scheme, the skin-care compound is (1E, 4E, 6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatriene-3-one, and the structural formula of skin-care compound is shown in the description. The skin-care compound is extracted out from pure natural plants containing (1E, 4E, 6E)-1,7-bis(4-hydroxyphenyl)-1,4,6-heptatriene-3-one. The skin-care product can be applied, as an irritant of human-dermal-fibroblastHDFa secreting collagen and a tyrosinase inhibitor, to the preparation of anti-aging and skin-whitening cosmetics.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a skin care compound, its preparation method and application, and skin care products. Background technique [0002] The skin is the largest organ in the body and an important barrier that protects the body from injury and maintains body temperature and moisture. At present, skin aging and skin diseases have received more and more attention. [0003] Among them, skin aging has a great relationship with its composition, and 75% of skin composition is collagen. Collagen is essential for skin growth, repair and nutrition; and two key elements of skin care (ie, moisturizing and anti-wrinkle) are related to collagen. Due to irresistible internal factors such as genetic factors and external stimuli such as ultraviolet rays and radiation, the collagen in the skin is lost, and the skin gradually ages. As we age, collagen in the skin gradually decreases. Therefore, supplemen...

Claims

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Application Information

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IPC IPC(8): C07C45/78C07C49/248A61K8/35A61Q19/08A61Q19/02
CPCA61K8/35A61K2800/782A61Q19/02A61Q19/08C07C45/78C07C49/248
Inventor 杜芝芝李明祥白雪张红霞李志坚解勇王雅琴许艳勇
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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