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Automatic production method of [18F] aluminum fluoride and NOTA labeling method
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A production method and labeling technology, applied in chemical instruments and methods, peptide preparation methods, organic chemistry, etc.
Active Publication Date: 2019-08-16
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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DANG Yonghong, LV Jingqiao, WANG Tong, etc. synthesized 2-~(18) using PET-MF-2V-IT-I fluorine multifunctional synthesis module in "Compilation of Abstracts of the Ninth National Nuclear Medicine Academic Conference of Chinese Medical Association" in 2011 F-fluoropropionic acid; Tang Ganghua, Tang Xiaolan, Wang Mingfang, etc. published tumor imaging agents in Nuclear Surgery, 2006, 59 18 The automatic synthesis of F-fluoroacetate, but has not yet been applied to [ 18 Automated synthesis of F]AlF and NOTA
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Embodiment 1
[0037] Example 1: [ 18 F] aluminum fluoride and NOTA marking method automated production method, comprises the following steps:
[0038] 1. Transformation of commercial domestic module PET-MF-2V-IT-I, including reaction solution group, HPLC group, wherein the reaction solution group includes QMA column, reaction bottle, reaction tube, waste liquid bottle, water recoverybottle, intermediate bottle, each The components are connected by liquid transfer pipes, such as figure 1 shown.
[0039] 2. Using the modified commercial domestic module PET-MF-2V-IT-I, the PETtrace cyclotron was used to test 18 O(p,n) 18Produced by F nuclear reaction 18 f - The ions are enriched and captured by the QMA column.
[0040] 3. Open the valves V9, V0 and V1, and use 0.9% sodiumchloride solution in the B1 bottle to elute the QMA-adsorbed 18 f - ions into reaction vial V1.
[0041] 4. Open valves V9 and V2, and add the acetonitrile solution in bottle B2 to the reaction bottle.
[0042] 5. ...
Embodiment 2
[0057] Example 2: [ 18 F] aluminum fluoride and NOTA marking method automated production method, comprises the following steps:
[0058] 1. Transformation of commercial domestic module PET-MF-2V-IT-I, including reaction solution group, solid phase extraction group, wherein the reaction solution group includes QMA column, reaction bottle, reaction tube, waste liquid bottle, water recovery bottle, intermediate bottle , each component is connected with a liquid transferpipe, such as figure 2 shown.
[0059] 2. Using the modified commercial domestic module PET-MF-2V-IT-I, the PETtrace cyclotron was used to test 18 O(p,n) 18 Produced by F nuclear reaction 18 f - The ions are enriched and captured by the QMA column.
[0060] 3. Open the valves V9, V0 and V1, and the 0.9% sodiumchloride solution in the B1 bottle elutes the adsorbed QMA 18 f - ions into reaction vial V1.
[0061] 4. Open valves V9 and V2, and add the acetonitrile solution in bottle B2 to the reaction bottl...
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Abstract
The invention relates to an automatic production method of an [18F] aluminum fluoride and NOTA labeling method. By reforming an existing domestic module PET-MF-2V-IT-I, a one-pot one-step method is used to automatically complete the complexing labeling of [18F]ALF and NOTA, a reaction solution obtains a high-purity imaging agent through two different separation methods of semi-preparative HPLC orsolid phase extraction, so that radioactive exposure is avoided, and high-dose production and clinical application of 18F-ALF-NOTA tracer agents are ensured.
Description
technical field [0001] The present invention involves two [ 18 F] aluminum fluoride and NOTA labeling automatic production method, specifically HPLC separation method and solid phase extraction separation method [ 18 F] Aluminum Fluoride with NOTA-P-D-Lys 6 -Automated production imaging agent of GnRH polypeptide[ 18 F]AlF-NOTA-P-D-Lys 6 -GnRH. Background technique [0002] Positron emission tomography (PET) imaging is to observe and study the physiological mechanism in vivo through positron imaging agents, and obtain information such as metabolic pathways, biomolecular mechanisms, receptors and enzyme functions in vivo without trauma. As one of the most advanced modern molecular imaging technologies, PET has been widely used all over the world. The key to the application and development of PET technology lies in the development of PET imaging agents. Due to the short half-life of the positronnuclide, the labeling method of the PET imaging agent requires the characteri...
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