Automatic production method of [18F] aluminum fluoride and NOTA labeling method
A production method and labeling technology, applied in chemical instruments and methods, peptide preparation methods, organic chemistry, etc.
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Embodiment 1
[0037] Example 1: [ 18 F] aluminum fluoride and NOTA marking method automated production method, comprises the following steps:
[0038] 1. Transformation of commercial domestic module PET-MF-2V-IT-I, including reaction solution group, HPLC group, wherein the reaction solution group includes QMA column, reaction bottle, reaction tube, waste liquid bottle, water recovery bottle, intermediate bottle, each The components are connected by liquid transfer pipes, such as figure 1 shown.
[0039] 2. Using the modified commercial domestic module PET-MF-2V-IT-I, the PETtrace cyclotron was used to test 18 O(p,n) 18Produced by F nuclear reaction 18 f - The ions are enriched and captured by the QMA column.
[0040] 3. Open the valves V9, V0 and V1, and use 0.9% sodium chloride solution in the B1 bottle to elute the QMA-adsorbed 18 f - ions into reaction vial V1.
[0041] 4. Open valves V9 and V2, and add the acetonitrile solution in bottle B2 to the reaction bottle.
[0042] 5. ...
Embodiment 2
[0057] Example 2: [ 18 F] aluminum fluoride and NOTA marking method automated production method, comprises the following steps:
[0058] 1. Transformation of commercial domestic module PET-MF-2V-IT-I, including reaction solution group, solid phase extraction group, wherein the reaction solution group includes QMA column, reaction bottle, reaction tube, waste liquid bottle, water recovery bottle, intermediate bottle , each component is connected with a liquid transfer pipe, such as figure 2 shown.
[0059] 2. Using the modified commercial domestic module PET-MF-2V-IT-I, the PETtrace cyclotron was used to test 18 O(p,n) 18 Produced by F nuclear reaction 18 f - The ions are enriched and captured by the QMA column.
[0060] 3. Open the valves V9, V0 and V1, and the 0.9% sodium chloride solution in the B1 bottle elutes the adsorbed QMA 18 f - ions into reaction vial V1.
[0061] 4. Open valves V9 and V2, and add the acetonitrile solution in bottle B2 to the reaction bottl...
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