Preparation method and detection method of fructus psoraleae standard decoction

A detection method and the technology of psoralen, which is applied in the field of preparation of psoralen standard decoction, can solve the problems that there is no preparation method and detection method report of psoralen standard decoction, and achieve shortened detection and analysis time and good specificity , good stability

Active Publication Date: 2019-08-20
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD +2
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the standard decoction is a "bridge" connecting traditional Chinese medicine decoction pieces and modern Chinese medicine preparations, it provides a reference for controlling the quality of the end product of Chinese medicine, and provides a basis for standardizing different forms of Chinese medicine and ensuring the uniformity of quality and consistency of curative effect. The reference object provides a reference object for evaluating the consistency of product quality of different manufacturers. Therefore, the formulation of the quality standard for standard Chinese medicine decoction will provide the basis for the formulation of quality standards for all final products of water decoctions derived from decoction pieces, but currently , there is no report about the preparation method and detection method of psoralen standard decoction

Method used

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  • Preparation method and detection method of fructus psoraleae standard decoction

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preparation example Construction

[0111] As mentioned above, the present invention provides a kind of preparation method of psoralen standard decoction, it comprises the following steps:

[0112] (1) Get the psoralea medicinal material, decoct it with water, and filter to obtain the filtrate;

[0113] (2) Concentrating and drying the filtrate in step (1), and then freeze-drying. The freeze-drying is divided into three stages: a. pre-freezing: the pre-freezing temperature is -50 ° C ~ -45 ° C; The temperature is -30°C to 0°C; c. Secondary drying for analysis: the drying temperature is 5 to 25°C to obtain the standard psoralen decoction.

[0114] In a preferred embodiment of the present invention, wherein, in step (1), the psoralen medicinal material is moderately crushed and soaked before decocting with water, and the soaking time is 30 minutes.

[0115] In a preferred specific embodiment of the present invention, wherein, in step (1), the filtering is hot filtering, and the filtering is performed by using a 1...

Embodiment 1

[0149] 1. The preparation method of psoralen standard decoction

[0150] (1) Take 100g of psoralen decoction slices, add water to decoct twice, add 8 times the amount of water to the first decoction, soak for 30 minutes and start decocting, turn on strong fire (500W), after boiling, adjust to slow fire (200W) decoction Boil for 60 minutes, filter with a 100-mesh filter cloth while it is hot, add 6 times the amount of water for the second decoction, turn on a strong fire (500W), after boiling, adjust to a simmering fire (200W) and cook for 45 minutes, and use a 100-mesh filter cloth while it is hot Filter and combine the two filtrates;

[0151] (2) Transfer the filtrate to a rotary evaporator for concentration (water bath temperature: 65°C, vacuum degree is -0.08~-0.09MPa), concentrate to a density of 1.03g / ml, adjust the solid content to 10%, and pack to 10ml In vials, half-stoppered, each bottle has a volume of 2.0ml, and after the filling is completed, transfer it to a vacu...

Embodiment 2

[0282] 1. The preparation method of psoralen standard decoction

[0283] (1) Take 100g of psoralen decoction slices, add water to decoct twice, add 7 times the amount of water to the first decoction, turn on the fire, after boiling, adjust to simmer for 60 minutes, filter with a 100-mesh filter cloth while it is hot, In the second decoction, add 4 times the amount of water, turn on the fire, and after boiling, adjust the fire to simmer for 45 minutes, filter with a 100-mesh filter cloth while it is hot, and combine the two filtrates;

[0284] (2) Transfer the filtrate to a rotary evaporator for concentration (water bath temperature: 60°C, vacuum degree is -0.08~-0.09MPa), concentrate to a density of 1.05g / ml, adjust the solid content to 14%, and pack to 10ml In vials, half-stoppered, each bottle has a volume of 2.0ml, and after the filling is completed, transfer it to a vacuum freeze dryer for pre-freezing. The pre-freezing temperature is -50°C, and the pre-freezing time is 3 ...

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Abstract

The invention relates to the field of traditional Chinese medicine modernization, in particular to a preparation method and a detection method of a fructus psoraleae standard decoction. The preparation method of the fructus psoraleae standard decoction comprises the following steps: decocting fructus Psoraleae medicinal materials with water, and filtering to obtain filtrate; concentrating and drying the filtrate, and then performing lyophilization which is divided into three stages: a. pre-freezing at the pre-freezing temperature of -50 DEG C to -45 DEG C; b. primary drying at the drying temperature of -30 DEG C to 0 DEG C; and c. secondary drying at the drying temperature of 5 DEG C to 25 DEG C, so as to obtain the fructus Psoraleae standard decoction. The preparation method of the invention has the beneficial effects that: the fructus psoraleae standard decoction has high paste yield, and has relatively stable content, relatively stable water content, moisture absorption resistance,and no impurity component through a 6-month accelerated stability test. The invention provides a method for measuring the total content and the total transfer rate of psoralen and isopsoralen, which has good specificity, good repeatability and good stability. A characteristic spectrum method of the invention adopts the ultra-high phase liquid phase, is simple, can greatly shorten the detection time and improve the production efficiency.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine modernization, in particular to a preparation method and a detection method of a standard psoralen decoction. Background technique [0002] The traditional Chinese medicine Psoralen is the dry and mature fruit of the leguminous plant Psoralea corylifolia L., also known as broken paper, Hu Jiuzi, etc. It is warm in nature and pungent in taste. It is mainly used for kidney deficiency and diarrhea, impotence, waist and knees Symptoms such as cold pain, deficiency cold, wheezing and coughing. Modern medicine has shown that psoraleae also has various pharmacological activities such as anti-tumor, anti-bacterial, anti-osteoporosis, and anti-estrogen-like effects, and can treat diseases such as vitiligo and psoriasis. [0003] Standard decoction, also known as standard decoction, is a traditional form of medicine widely used in clinical practice. Standard decoction follows the theory of tradi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06A61K36/487
CPCG01N30/02G01N30/06A61K36/487G01N2030/042A61K2236/331A61K2236/51
Inventor 孙宜春朱鹤漆正方李慧馨安跃谢隼张建锋娄涛涛张锋潘仁锋林必芬
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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