Application of protein c in the treatment of hepatic portal hypertension

A kind of use, liver cell technology, applied in the field of biomedicine, can solve the problems of lack of research on the pathogenesis and treatment mechanism of portal hypertension
CN110157706BActive Publication Date: 2021-07-06首都儿科研究所
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
首都儿科研究所
Publication Date
2021-07-06

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Abstract

This application relates to the application of protein C in the treatment of hepatic portal hypertension. This application relates to the correlation research between protein C and portal hypertension, and also relates to protein C inhibitors, including miRNA. Protein C inhibitor (miRNA) can inhibit the proliferation of hepatocytes and promote the apoptosis of hepatocytes, which can reduce the proliferation of hepatic sinusoids, so that the portal blood flow is smooth and the portal pressure is reduced. This has opened up new research prospects for the treatment of portal hypertension (especially portal cavernous degeneration), and provided new ideas for the in-depth development and clinical treatment of miRNA drugs.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to the application of protein C in the treatment of diseases related to hepatic portal hypertension. Background technique

[0002] Portal hypertension (PH), also known as portal hypertension, portal hypertension, and portal hypertension, is defined as portal hypertension (PH) when the portal pressure increases more than 5 mmHg relative to systemic blood pressure. The basic pathological and physiological characteristics of PH are obstruction and / or increased blood flow in the portal vein system, continuous increase in hydrostatic pressure in the portal vein and its branches, and the formation of collateral circulation. Cirrhosis of the liver due to various causes is its most common cause. The main clinical manifestations are gastroesophageal varices (GOV), esophagogastric variceal bleeding (EVB), ascites, and hepatic encephalopathy, among which EVB is the most lethal complication of PH, a...

Claims

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