Staining agent for early diagnosis of esophageal cancer and preparation method of staining agent

Abstract

The invention discloses a staining agent for early diagnosis of esophageal cancer, a preparation method of the staining agent, and application of xanthan gum in an iodine staining agent for living body staining. The staining agent comprises the following components in percentages by weight: 0.05-0.1% of xanthan gum, 0.5-1% of iodine, 1.25-1.5 times of iodine weight of potassium iodide, and the balance of water. A certain proportion of xanthan gum is compounded with the iodine and the potassium iodide, the content of the iodine and the potassium iodide is reduced, meanwhile, enough dyeing timecan be provided, the influence on patients is small, the staining agent is safe to us, examination time can be effectively saved, the dosage of anesthetic drugs is reduced, the examination indicationis expanded, the preparation cost is low, and good economic and social benefits are achieved.

Description

technical field [0001] The invention relates to the technical field of medical detection reagents, in particular to a dye for early diagnosis of esophageal cancer, its preparation method and the application of xanthan gum in iodine dye for living body dyeing. Background technique [0002] Esophageal cancer is a common digestive tract tumor; my country is an area with a high incidence of esophageal cancer, and more than 150,000 people die each year. Most patients with esophageal cancer have developed to the middle or late stage when they come to the hospital for treatment. The clinical curative effect of the middle and late stage patients is poor and the cost is high. Therefore, it is of great significance to carry out early diagnosis of esophageal cancer. A common method for early diagnosis of esophageal cancer is: spray the pre-prepared iodine-containing solution to the patient's esophageal mucosa through a gastroscope, and observe the color change of the mucosa. The squa...

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Problems solved by technology

[0004] (1) Lugol's iodine solution is highly irritating to patients' esophageal mucosa. During use, the patient's esophageal mucosa is prone to spasm and contraction, which seriously affects the doctor's observation of lesions and sampling and biopsy. Among patients with esophageal cancer, middle-aged and elderly people The proportion is much higher than that of young people, and the proportion of middle-aged and elderly patients with heart disease is relatively high, and it is easy to induce arrhythmia under the adverse stimulation of iodine solution; although the iodine content of the diluted solution is significantly lower than that of the original solution, some patients still have heartburn, Chest pain, nausea, vomiting, allergies and other adverse reactions;

[0005] (2) In order to eliminate the irritation of iodine solution, the esophagus needs to be flushed with buffer solution after staining, which increases the medical cost and the time of gastroscopy examination, and the increase of operation time also means that the amount of anesthesia, sedation and other drugs used during the examination increase, which is bound to be accompanied by an increase in drug toxicity and side effects, and at the same time, the medical expenses borne by patients also increase accordingly;

[0006] (3) Patients with thyroid disease need to strictly control iodine intake, and patients with hyperkalemia need to strictly limit potassium intake. The iodine content and potassium content of Lugol's iodine solution are high. adverse effects on patients

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