Application of vanillic acid in inhibiting the growth of multi-drug resistant Enterobacter cloacae

A technology of Enterobacter cloacae and Enterobacter cloacae, applied in the field of medicine, to achieve the effect of reducing the mortality rate, solving the problem of drug-resistant infection, and having wide application value
CN110215446BActive Publication Date: 2021-08-13SHAANXI UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHAANXI UNIV OF SCI & TECH
Publication Date
2021-08-13

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Abstract

The invention discloses the application of vanillic acid in inhibiting the growth of multidrug-resistant Enterobacter cloacae. The invention utilizes the disc diffusion method to determine the drug resistance of Enterobacter cloacae to antibiotics, and determines that the minimum bactericidal concentration of vanillic acid to multidrug-resistant Enterobacter cloacae is 1.6mg / mL and the minimum pH The bacterial concentration was 1.2 mg / mL, revealing that the non-antibiotic compound vanillic acid has an inhibitory effect on multidrug-resistant Enterobacter cloacae, and has wide application value in the field of medicine.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of vanillic acid in inhibiting the growth of multidrug-resistant Enterobacter cloacae. Background technique

[0002] Enterobacter cloacae is an Enterobacteriaceae bacterium that widely exists in the intestines of animals and humans, and is a common pathogenic bacteria in hospital-acquired infections (Ning Xingwang, Zhu Huibin, Kuang Min, Xie Xiaobing, Qian Chun. 107 strains of Enterobacter cloacae produced Detection of ESBLs and AmpC enzymes and analysis of drug resistance [J]. Practical Preventive Medicine, 2018, 25(05): 534-537.), can cause multi-system infections, respiratory tract infection is the most common, and can also cause sepsis, urinary tract infection infections, wound infections, and urinary tract infections. With the overuse and abuse of antibiotics, the extensive use of immunosuppressants, chemotherapy drugs, and various invasions, the clinical isolation r...

Claims

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