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Hybridized paper mulberry alcohol composition and application thereof

A technology of composition and alcohol compound, which is applied in the direction of drug combination, drug delivery, plant raw materials, etc., to achieve fair and bright skin, inhibit melanin production, and improve whitening efficacy

Inactive Publication Date: 2019-09-10
兰溪市立顺生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report of licorbitol and its composition at present, and there is no report of licorbitan and its composition inhibiting melanin deposition, nor is it used as an active ingredient in a whitening preparation for inhibiting melanin production reports and reports on drugs for the prevention and treatment of melanoma-related diseases

Method used

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  • Hybridized paper mulberry alcohol composition and application thereof
  • Hybridized paper mulberry alcohol composition and application thereof
  • Hybridized paper mulberry alcohol composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] This embodiment provides a composition of hybrid resin for injection, specifically a freeze-dried microemulsion of hybrid resin for injection, wherein, by weight percentage, it contains the following ingredients:

[0099]

[0100] Specifically, the oil for injection is a mixture of injection-grade sesame oil and vitamin E in a weight ratio of 1:0.05;

[0101] Described emulsifying agent is lecithin and glutamic acid that weight ratio is 1:0.01;

[0102] The stabilizer is sodium bisulfite.

[0103] The preparation method of the injection hybrid resin composition comprises: when preparing the oil phase, hybrid resin alcohol I, hybrid resin alcohol II, 5,7,2′,4′-tetrahydroxy- 3-Gerin, emulsifier and absolute ethanol are mixed and stirred until clear, then oil for injection and stabilizer are added, further stirred until clear, and the ethanol is evaporated in a vacuum to obtain an oil phase.

[0104] The injection composition containing hybrididol of the present inven...

Embodiment 2

[0106] An injectable hybrid gum composition, which comprises:

[0107] 1) hybrid tree alcohol Ⅰ;

[0108] 2) Hybrid gum Ⅱ;

[0109] 3) 5,7,2′,4′-tetrahydroxy-3-geranin;

[0110] 4) Oil for injection;

[0111] 5) emulsifiers; and

[0112] 6) Stabilizer.

[0113] The oil for injection is a mixed oil of injection-grade hydrogenated castor oil, injection-grade olive oil, and vitamin E derivatives, wherein the weight ratio of injection-grade hydrogenated castor oil, injection-grade olive oil and vitamin derivatives is 1:2:0.3 , the vitamin E derivative is d-alpha-tocopheryl acetate. Some fatty acid esters and vitamin E and their derivatives used as oil for injection have significant anti-oxidation, scavenging free radicals, preventing cancer, and improving the body's immunity, and the oil for injection and hybrid resin and 5, The combination of 7,2′,4′-tetrahydroxy-3-geranin can exert a synergistic effect, improve the body’s immunity, and strengthen the hybrid Anti-melanoma ...

Embodiment 3

[0123] Example 3 is substantially the same as Example 2, except that in Comparative Example 3, the following ingredients in the hybrid injection composition account for the weight percent of the composition:

[0124]

[0125] And specifically, the oil for injection is a mixture of injection-grade sesame oil and vitamin E in a weight ratio of 1:0.05;

[0126] Described emulsifying agent is lecithin and glutamic acid that weight ratio is 1:0.01;

[0127] The stabilizer is sodium bisulfite.

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Abstract

The invention provides a hybridized paper mulberry alcohol composition and application thereof, and belongs to the technical field of hybridized paper mulberry deep processing. The composition includes a hybridized paper mulberry alcohol I shown in a formula (I), a hybridized paper mulberry alcohol II shown in a formula (II) and 5,7,2',4-tetrahydroxy-3-germacrone and can be used for preparing a whitening preparation, and by putting the composition to the region needed by individuals, the purpose of restraining melanogenesis at the region needed by individuals can be achieved; the composition can also contain oil for injection, an emulsifier and a stabilizer, and the composition can be applied to the whitening preparation and preventing and / or treating melanoma. The composition has the tyrosinase inhibitory activity, can restrain melanogenesis, has the added whitening effect as the whitening preparation, meanwhile, can also prevent and treat melanoma by restraining tyrosinase activity and restraining melanoma cell proliferation and / or inducing tumor cell apoptosis, and has the good development prospect.

Description

technical field [0001] The invention belongs to the technical field of hybrid tree deep processing, and in particular relates to a hybrid tree alcohol composition and application thereof. Background technique [0002] Broussonetia papyrifera (Linn.) L'Hér.ex Vent. is a plant of the moraceae genus Broussonetia papyrifera, which is produced in the north and south of China. It is distributed and cultivated in the temperate and tropical regions of China. It has fast growth, strong adaptability, wide distribution, It is an important greening and economical species due to its advantages of easy reproduction, high heat, and short rotation period. The fruit, leaves, branches, stem bark milk and root bark of the mulberry tree can be used as human medicine. It has the effects of nourishing the kidney and diuresis, clearing the liver and improving eyesight, strengthening the stomach, reducing inflammation, cooling blood and stopping bleeding. Among them, mulberry leaves, also known as...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/19A61K9/107A61K47/44A61K36/60A61P17/00A61P35/00A61K8/49A61Q19/02
CPCA61K8/498A61K9/0019A61K9/1075A61K9/19A61K31/352A61K36/60A61K47/44A61K2800/782A61P17/00A61P35/00A61Q19/02A61K2300/00
Inventor 鲁新康陈宇杨树海
Owner 兰溪市立顺生物有限公司
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