Porous composite ceramic capable of guiding bone regeneration and preparation method of porous composite ceramic

Abstract

The invention discloses porous composite ceramic capable of guiding bone regeneration. The porous composite ceramic is formed by the combination of calcium sulfate and calcium phosphate in any other way except the coating to form a porous structure of an arbitrary shape, the pore pattern of pores with at least one dimensional direction in the three-dimensional spatial direction of the porous structure is regular, the distance from the center of each pore to the edge is 50-2000 microns, and all the pores are mutually communicated. The invention further provides a preparation method of the porous composite ceramic. The functional defect of a single composite is well overcome, cells and blood vessels are facilitated to grow into the ceramic to regenerate new bone, and new bone tissue is beneficial to the formation of dense bone with Huffler's system structure; meanwhile, the porous composite ceramic has the advantages that the pore shape rules are controllable, which is beneficial to unify the quality standard of the product and also facilitates the detection and quality control of the product; therefore, the porous composite ceramic is quite suitable for commercial and mass production applications.

Description

technical field [0001] The invention relates to the technical field of bioceramics, in particular to a porous composite ceramic capable of guiding bone regeneration and a preparation method thereof. Background technique [0002] Calcium phosphate has always been one of the best materials for bone defect filling and repair due to its similarity to bone tissue inorganic mineral composition and abundant sources. At the same time, clinical practice has proved that it is also very important for bone implant materials to have pores with a specific size and through pores. Because the pores with a specific size and through them are conducive to the growth of new bone and blood vessels, and realize the metabolism of new bone. For this reason, various techniques for processing calcium phosphate into a porous structure have been reported so far. [0003] However, the biological properties of purely porous calcium phosphate ceramics are not ideal. For example, due to the good biocomp...

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Problems solved by technology

However, the calcium phosphate-calcium sulfate composite porous ceramics prepared by the above method have many disadvantages.

First of all, sulfuric acid / phosphoric acid is used as a reactant to react with porous bovine bone. The preparation conditions, because sulfuric acid is used for the reaction, have a relatively high risk of environmental pollution, and the synthesis process is also highly dangerous, which is not conducive to safe and environmentally friendly production.

Secondly, using porous bovine bone as a raw material, there are many subjective factors in the process of raw material selection, and the pore structure, size and pore type are random and uncontrollable, so the performance of the final product manufactured in this way varies greatly. Quality system control is also difficult

Finally, using porous bovine bone as a raw material to prepare porous ceramic scaffolds is difficult to achieve personalized product customization

[0007] In addition, a document entitled "Biological properties of biphasic calcium-phosphate bioceramics / calcium sulfate bone cement porous three-dimensional scaffold" (Chinese Tissue Engineering Research, 2014,18(8):1161-1164) reported that calcium Mixed with calcium sulfate bone cement to prepare a porous scaffold, but the reported pore diameter is 0.5-1.5 microns, and the pore structure is irregular, so it is impossible for cells and blood vessels to grow into this kind of material in the actual bone defect repair. in such small pores

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