A kind of preparation method of 1,1-diaryl alkane derivative

Abstract

The invention discloses a preparation method of 1,1-diaryl alkane derivatives. The method uses olefin compounds, (hetero) aromatics and N-hydroxyphthalimide ester compounds as raw materials to construct C(sp3)-C(sp3) / C(sp3) under photoredox catalysis conditions. The ‑C (sp2) bond realizes the 1, 2‑difunctionalization reaction of alkenes, and prepares a series of 1, 1‑diaryl alkane derivatives.

Description

technical field [0001] The application belongs to the technical field of organic synthesis, and in particular relates to a preparation method of 1,1-diaryl alkane derivatives. Background technique [0002] Carboxylic acid derivatives-N-hydroxyphthalimide alkyl esters (alkyl NHP esters) have become a very important alkylating agent in organic synthesis, not only by using cheap, readily available and stable Fatty acids are simple to prepare, and can easily generate alkyl radicals by decarboxylation under photoredox catalysis, transition metal catalysis, etc. (1) Org.Lett.2018, 20, 6659-6662; 2) Org.Lett.2018 , 20, 888-891; 3) Org. Lett. 2018, 20, 3496-3499; 4) ACS Catal. 2018, 8, 7489-7494; 5) Org. Lett. 2018, 20, 1546-1549; 6) Org.Lett.2018, 20, 224-227; 6) Chem.Eur.J.2018, 24, 4552-4555; 7) Angew.Chem.Int.Ed.2017, 56, 3708-3711; 9) J. Org. Chem. 2015, 80, 6025-6036; 10) NATURE COMMUNICATIONS, (2018) 9: 5215, etc.). In recent years, alkyl NHP esters have been used by organ...

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Problems solved by technology

However, current styrene difunctionalization reactions involving alkyl NHP esters mainly focus on the construction of C(sp3)-C(sp3) / C(sp3)-heteroatom bonds, while styrene and (hetero)arenes are bonded via C (sp2)-H breaks, and the alkylation reaction of building C(sp3)-C(sp3) / C(sp3)-C(sp2) bond has not been reported in the prior art

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