7 results about "Photoredox catalysis" patented technology

This invention discloses a migration C(sp²)-H / C(sp³)-H cross-coupling reaction achieved using metal / photoredox catalysis, belonging to the fields of organic chemistry and medicinal chemistry. Under the action of a nickel source, photocatalyst, ligands, base, and additives, this invention enables the reaction of alkanes with ortho-alkenyl-substituted aryl halides or ortho-pyridine-substituted aryl halides in an organic solvent under light irradiation, yielding a series of polysubstituted olefins or polysubstituted aromatic compounds with excellent regioselectivity, stereoselectivity, and good yields, which can serve as active pharmaceutical molecules. This invention uses inexpensive transition metal nickel as a catalyst, readily available alkanes and haloaromatics as raw materials, and features mild and simple conditions, good functional group compatibility, and easy operation.

The application discloses a synthesis method of aromatic aldehyde, comprising the following steps: under inert atmosphere, a compound shown in formula I and a compound shown in formula II are reacted in an organic solvent containing a photocatalyst, a nickel catalyst, a ligand, a base and water under blue light irradiation to obtain aromatic aldehyde shown in formula III; formula I, formula II and formula III are structures as follows, ring A is selected from benzene, pyridine, thiophene, furan, pyridazine, indazole, indole, isoquinoline, quinoline, naphthalene, benzothiophene, dibenzofuran or dibenzothiophene; the application generates formyl radicals under the nickel synergistic photo-oxidation and reduction catalytic condition, and the formylation of bromobenzene and its derivatives is realized in a simple and efficient one-pot way, aromatic aldehyde is constructed, and the reaction has the characteristics of cheap and easily available raw materials, mild reaction conditions, controllable synthesis process, high separation yield / yield, green environmental protection, wide substrate applicability and the like.

A dental adhesive composition containing a polymerizable monomer (A) having an acidic group and a photoredox catalyst (B) having a singlet excited state reduction potential ES1red of 1.5 V vs SCE or more.

The disclosure relates to photoredox catalysts (PC) and methods for the Birch reductions of aromatic substrates, such as benzene, benzeneoid, and heteroaromatic compounds, using light as the driving force. Certain aspects of the disclosure encompass methods for reduction of aromatic substrates. The method comprises contacting an aromatic substrate with a sacrificial electron donor in the presence of a photoredox catalyst in a solvent, thereby forming a reaction mixture; exposing the reaction mixture to visible or UV light under reaction condition sufficient to reduce the aromatic substrate compound.

This invention relates to the field of fluorescent compound preparation technology, and discloses a method for synthesizing naphtho[1',2'4,5]imidazo[1,2-a]pyridine fluorescent compounds, including a cyclized compound, wherein the cyclized compound includes styrene compounds and imidazolium heterocyclic compounds, and the cyclized compound is a naphtho[1',2'4,5]imidazo[1,2-a]pyridine fluorescent compound; it also includes a method for synthesizing naphtho[1',2'4,5]imidazo[1,2-a]pyridine fluorescent compounds. This invention utilizes a synergistic combination of a photo-redox catalyst and a cobalt oxime catalyst to achieve a [4+2] cyclization reaction of olefins with imidazopyridines. Under photochemical conditions, imidazopyridine compounds and styrene compounds undergo a [4+2] cyclization reaction with the addition of the photo-redox catalyst and the cobalt oxime catalyst. This facilitates the rapid synthesis of naphtho[1',2'4,5]imidazo[1,2-a]pyridine fluorescent compounds. It avoids the use of precious metal catalysts or chemical oxidants, and the reaction conditions are mild, making it suitable for the mass production and processing of naphtho[1',2'4,5]imidazo[1,2-a]pyridine fluorescent compounds, reducing synthesis and production conditions, saving costs, and improving efficiency.

The method comprises the following steps: in a nitrogen atmosphere, mixing a compound 1, a compound 2, an oxidant, alkali, a photocatalyst and a solvent, carrying out a reaction under the conditions of room temperature and illumination, carrying out TLC monitoring until the reaction is completed, and carrying out separation and purification on the reaction mixture to obtain an isoquinoline diketone compound 3; the method disclosed by the invention is mild in condition, wide in substrate application range and capable of efficiently synthesizing the polysubstituted nitrogen-containing compound; .

The invention discloses a C-H 3, 3-difluoroallylation reaction method of a 1, 2-dihydroquinoxaline-2-ketone derivative, which comprises the following steps: by taking the 1, 2-dihydroquinoxaline-2-ketone derivative as shown in a formula I and 3-bromo-3, 3-difluoro-1-propylene as coupling reagents, carrying out a reaction on the 1, 2-dihydroquinoxaline-2-ketone derivative and 3-bromo-3, 3-difluoro-1-propylene in an environment of inorganic alkali and organic amine under the catalysis of a photooxidation reduction catalyst, and then carrying out a reaction to obtain the C-H 3, 3-difluoroallylation reaction product of the 1, 2-dihydroquinoxaline-2-ketone derivative. And carrying out a coupling reaction under a visible light condition to obtain a compound shown in a formula II. The C-H 3, 3-difluoroallylation product of the 1, 2-dihydroquinoxaline-2-ketone derivative is synthesized under mild one-step reaction conditions for the first time, and a green synthesis path is provided for medicine molecules (such as antitumor / antiviral compounds) containing a gem-difluoroallyl structure.