The invention discloses a method for realizing N-alpha site arylation of a
nitrogen-containing heterocyclic ring by
photocatalysis, relates to the technical field of catalytic synthesis, and in particular relates to a method for realizing N-alpha site arylation of the
nitrogen-containing heterocyclic ring by
photocatalysis under the condition of no additional HAT
reagent. The method comprises the following steps: adding a brominated aromatic compound, a
nitrogen-containing compound, Ir [dF (CF3) ppy] 2 (dtbbpy) PF6,
nickel chloride, 4, 4-di-tertbutyl-2, 2-dipyridyl and alkali into a mixed
solvent to obtain a reaction
mixed solution, and performing
light source irradiation at
room temperature in an
inert gas
atmosphere to obtain the nitrogen heterocyclic ring N-alpha-position
aryl compound. The
coupling of C (sp3)-C (sp2) is completed under the condition that no HAT
reagent is added, and the reaction is simple and convenient; and the cheap brominated aromatic compound and the
photosensitizer are used, so that the economic and environment-friendly characteristics of the reaction are reflected. The method disclosed by the invention is very simple to operate, the raw materials are commercially available, the reaction can be realized at a higher yield by using a catalytic amount of a photooxidation reduction catalyst, and the method is high in
atom economy and has wide substrate universality. The method is applied to the field of
organic synthesis.