Direct aromatic carbon-oxygen and carbon-hydrogen bond functionalization via organic photoredox catalysis

A technology of alkoxy and heteroaryl, applied in the field of direct aromatic carbon-oxygen and carbon-hydrogen bond functionalization via organic photoredox catalysis, which can solve the problems such as the difficulty of realizing C-F bond

Pending Publication Date: 2022-03-15
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In conclusion, despite the increasing importance of fluorinated reagents in drug d...

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  • Direct aromatic carbon-oxygen and carbon-hydrogen bond functionalization via organic photoredox catalysis
  • Direct aromatic carbon-oxygen and carbon-hydrogen bond functionalization via organic photoredox catalysis
  • Direct aromatic carbon-oxygen and carbon-hydrogen bond functionalization via organic photoredox catalysis

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Embodiment Construction

[0069] The present invention can be understood more readily by reference to the following detailed description of the invention and the Examples included therein.

[0070] Before the compounds, compositions, articles, systems, devices and / or methods of the present invention are disclosed and described, it is to be understood that they are not limited to specific synthetic methods unless otherwise indicated, or that they are not limited to specific synthetic methods unless otherwise indicated. Reagents, so they can of course vary. It is also to be understood that terminology used herein is for the purpose of describing particular aspects only and is not intended to be limiting. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, exemplary methods and materials are now described.

[0071] Although various aspects of the invention may be described and claimed in particular statutory c...

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Abstract

The present invention generally relates to methods for preparing substituted aromatics via direct C-H, C-O, C-S or C-N bond conversion and methods for synthesizing isotopically labeled substituted aromatics via direct carbon-halogen bond conversion. The invention also relates to an anaerobic catalyst system comprising an acridinium photocatalyst and a nucleophile selected from the group consisting of halides, cyanides and isotopically labeled amines. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Application Serial No. 62 / 812,179, filed February 28, 2019, the contents of which are hereby incorporated by reference in their entirety. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with Government support under Grant Nos. GM120186 and EB014354 awarded by the National Institutes of Health. The government has certain rights in this invention. Background technique [0005] Aromatic fluorination has attracted considerable attention in the development of pharmaceuticals and agrochemicals, leading to an urgent need to develop simple fluorination methods. Although a variety of methods have recently been developed for the formation of 19 F] The cross-coupling method of C-F bond (Lee et al's (2011) "Science (Science)" 334:639-642; Lee et al's (2012) American Chemical Society Journal (J.Am.Chem.Soc. )” 134:17456-17458; Mossine et al. (2014) ...

Claims

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Application Information

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IPC IPC(8): A24D3/16B01D15/08B01D53/14
CPCB01J35/004C07B2200/05C07C41/22C07C253/30C07C231/12C07C45/63C07C67/307C07C67/287C07C303/30C07D239/96C07D213/69C07D215/20C07D231/56C07D235/24C07D263/56C07J11/00C07J1/0059B01J31/006C07C17/12C07C17/361B01J2231/46C07C43/29C07C49/84C07C47/575C07C69/92C07C69/736C07C69/738C07C255/54C07C235/60C07C309/66C07C43/225C07C25/13C07C25/18C07C25/22C07B59/001C07C269/06C07D263/58C07D311/22
Inventor 李子博D·尼斯维茨W·陈
Owner THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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