Polyphenols compound monomer in periploca sepium bunge, preparing method of compound monomer and application to electronic cigarette

A technology of polyphenolic compounds and willow bark, applied in the field of phytochemistry, can solve problems such as no relevant reports on the application, and achieve the effects of good antibacterial activity, easy popularization and application, and increased shelf life.

Inactive Publication Date: 2019-09-24
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the compound and its application

Method used

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  • Polyphenols compound monomer in periploca sepium bunge, preparing method of compound monomer and application to electronic cigarette
  • Polyphenols compound monomer in periploca sepium bunge, preparing method of compound monomer and application to electronic cigarette
  • Polyphenols compound monomer in periploca sepium bunge, preparing method of compound monomer and application to electronic cigarette

Examples

Experimental program
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Effect test

Embodiment 1

[0044] The preparation method of polyphenolic compound monomer in bark willow bark comprises the following steps:

[0045] Step (1), extraction of extract: crush the dried willow bark into 30-50 mesh, use 70% ethanol aqueous solution as the extraction solvent, extract at room temperature, filter the extract, and concentrate the filtrate under reduced pressure to obtain extract;

[0046] Step (2), one-time silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and the volume ratio is 10:1, 10:3 in sequence , 10:5, 10:6, 10:7, 10:9, and 10:10, each gradient eluted to the TLC plate without spots, then replaced the next gradient elution; collected the gradient elution of each gradient and Concentrated and monitored by TLC, the same fractions were combined to obtain seven fractions A1-A7;

[0047]Step (3), secondary silica gel column chr...

Embodiment 2

[0050] The preparation method of polyphenolic compound monomer in bark willow bark comprises the following steps:

[0051] Step (1), extraction of extract: crush the dried willow bark into 30-50 mesh, use 95% ethanol aqueous solution as the extraction solvent, extract at room temperature, filter the extract, and concentrate the filtrate under reduced pressure to obtain extract;

[0052] Step (2), one-time silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and the volume ratio is 10:1, 10:3 in sequence , 10:5, 10:6, 10:7, 10:9, and 10:10, each gradient eluted to the TLC plate without spots, then replaced the next gradient elution; collected the gradient elution of each gradient and Concentrated and monitored by TLC, the same fractions were combined to obtain seven fractions A1-A7;

[0053] Step (3), secondary silica gel column ch...

Embodiment 3

[0061] The preparation method of polyphenolic compound monomer in bark willow bark comprises the following steps:

[0062] Step (1), extraction of extract: crush the dried willow bark into 30-50 meshes, use 80% ethanol aqueous solution as the extraction solvent, extract at room temperature, filter the extract, and concentrate the filtrate under reduced pressure to obtain extract;

[0063] Step (2), one-time silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and the volume ratio is 10:1, 10:3 in sequence , 10:5, 10:6, 10:7, 10:9, and 10:10, each gradient eluted to the TLC plate without spots, then replaced the next gradient elution; collected the gradient elution of each gradient and Concentrated and monitored by TLC, the same fractions were combined to obtain seven fractions A1-A7;

[0064] Step (3), secondary silica gel column ...

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Abstract

The invention relates to a polyphenols compound monomer in periploca sepium bunge, a preparing method of the compound monomer and application to an electronic cigarette, and belongs to the technical field of phytochemistry. The compound has the structural formula shown as the formula (I). The compound is separated from the periploca sepium bunge first, the compound is identified as the polyphenols compound through a nuclear magnetic resonance and mass spectroscopy method, and the specific structure of the compound is represented. The compound is remarkable in antifungal activity and has the lowest restraining concentration of 1.5625 microgram per milliliter. Meanwhile, the compound shows the quite good antibacterial activity. The compound monomer has a good antibacterial effect, can prolong the shelf life of electronic cigarette liquid and is easy to apply and popularize after being used in the electronic cigarette liquid.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a polyphenolic compound monomer in bark willow bark, a preparation method thereof, and an application in electronic cigarettes. Background technique [0002] Periploca sepium Bunge (Periploca sepium Bunge), also known as goat's milk bar, acanthus bark, croissant, sheep peach, etc., belongs to the dicotyledonous class, Romoaceae, and Periploca is a deciduous vine shrub. Its characteristics are light-loving, drought-tolerant, cold-resistant, and salt-alkali-resistant. The root system is deeply distributed and often clustered. The initial growth diameter is erect, and then gradually creeps or twines. Its root bark is used in traditional Chinese medicine to treat rheumatic arthralgia, soreness of the waist and knees, heart palpitations, shortness of breath, swollen feet, and dysuria. [0003] Current research shows that there are mainly cardiac glycosides, sapon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/78C07C45/79C07C47/575A01N35/04A01P1/00A01P3/00A24B15/16A24F47/00
CPCA24F47/008A01N35/04A24B15/16A24B15/167C07C47/575
Inventor 陈永宽赵伟洪鎏朱东来巩效伟李寿波李廷华张霞韩熠
Owner CHINA TOBACCO YUNNAN IND
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