The invention discloses a multi-enzyme Chinese and western medicine composite preparation for treating chronic nephritis. The multi-enzyme Chinese and western medicine composite preparation is prepared from a traditional Chinese medicine ingredient extracting solution, western medicine ingredients and multi-enzyme. The traditional Chinese medicine ingredient extracting solution is prepared from, by weight, periploca sepium, potentilla multifida, ligusticum, myrrh, gemma agrimoninae, oregano, perfoliote knotweed herbs, satyrium roots, tribulus terrestris, raspberries, citron, dryopteris atrata, herba cistanche, rhizoma atractylodis, beautiful sweetgum fruit, ardisiae japonica, radix achyranthis bidentatae, ophiopogon latifolius, pangolin, roots of garland roses, common euscaphis fruit seeds, small centipeda herbs, christia constricta, Chinese yam, radix scrophulariae, oldenlandia diffusa, lalang grass rhizome, herba epimedii, human placenta, notopterygium roots, and flaccid knotweed herbs. The western medicine ingredients comprise diclofenac sodium, carboxymethyl starch sodium, casein phosphopetides, povidone and menthol. The multi-enzyme comprises, by weight, bromelain, lumbrukinase, lactase and cysteine protease. The composite preparation has the effects of clearing away heat and toxic materials, inducing diuresis to reduce edema and warming the kidney to excrete dampness.