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Application of rutaecarpine to preparation of medicine for treating psoriasis

A technology of evodiamine and Evodia rutaecarpa, applied in the field of medicine, can solve the problems of no evodiamine and other problems, achieve the effect of reducing the thickness of the epidermis, improving the symptoms of spleen function damage, and restoring the balance of TH17/Treg cells

Inactive Publication Date: 2019-10-25
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports on the application of evodiamine in the preparation of drugs for the treatment of psoriasis

Method used

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  • Application of rutaecarpine to preparation of medicine for treating psoriasis
  • Application of rutaecarpine to preparation of medicine for treating psoriasis
  • Application of rutaecarpine to preparation of medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This example is the observation of the therapeutic effect of evodiamine on psoriasis.

[0039] Weigh 0.109172g of evodiamine (purity of rutadiamine is 98%), add 5.56ml of polyethylene glycol 400, mix well, the weight of the mouse is 20g, and prepare 20% w / w evodiamine polyethylene glycol 400 solution, spare. 24 BABL / C mice (7-8 weeks), 6 in a group, were divided into four groups: normal group (con), model group (IMQ), positive group (TK) and evodiamine group (WZY). The back of each group of mice was depilated with 6% w / w sodium sulfide solution, and administered after resting for two days. The normal group only used petroleum jelly to smear the mouse back skin every day, except the normal group, other groups smeared 62.5mg of 5% w / w imiquimod (IMQ) cream every day to induce the skin to produce psoriasis-like symptoms, and established psoriasis. Psoriasis model. Modeling continued for 7 days, and 6 hours after applying imiquimod daily, the model group applied 100 mg o...

Embodiment 2

[0042] This example is an analysis of the therapeutic effect of evodiamine on psoriasis

[0043] For the four groups of mice after the 7-day modeling in Example 1, the model group and the rutadiamine group were smeared with 100 mg of rutadiamine polyethylene glycol 400 solution, and the positive group was smeared with 80 mg of 0.1% w / w tacrolimus After 4 hours of cream administration, the eyeball was removed to take blood, centrifuged at 12000r / min at 4°C for 10 minutes, and the supernatant was taken and stored at -80°C for testing. The eyeball serum of each group was taken out and placed on ice, diluted with deionized water to the detection range of the ELISA kit, and IL-1β, IL-17A, IL-6, IL-22, IL-23, IFN-γ and TNF- βELISA kits were used to detect the expression levels of IL-1β, IL-17A, IL-6, IL-22, IL-23, IFN-γ and TNF-β in each group; at the same time, the skin tissue samples from the back of the mice were taken and treated with 4% fixed with paraformaldehyde, and carried o...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to an application of rutaecarpine to preparation of a medicine for treating psoriasis. The rutaecarpine is applied to the medicine for treating the psoriasis, expression of inflammatory factors such as IL-17A and IL-6 can be obviously reduced, Treg cell functions are promoted and enhanced, immune reaction caused by effector Tcells and autoreactive T cells is inhibited, TH17 / Treg cell balance is restored, so that skin tissue immune change caused by the psoriasis is adjusted, inflammatory reaction of the psoriasis is relieved, and intercurrent immune system spleen function lesion symptoms of the psoriasis are improved. Besides, the medicine inhibits psoriatic skin tissue epidermis thickening, epidermis projection acanthosis and regular extension, parakeratosis, complete keratosis, corium layer inflammatory cell infiltration and skin histopathology change caused by the psoriasis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of evodiamine in the preparation of medicines for treating psoriasis. Background technique [0002] Psoriasis is a common type of scaly papular skin disease usually accompanied by abnormal proliferation of keratinocytes. It is a chronic and easily relapsing inflammatory skin disease. The incidence rate of psoriasis in the world is 0.1-3%, and the incidence rate varies greatly in different countries. In Europe and the United States, the incidence rate is as high as 2-3%. patient. Psoriasis patients have a long course of disease, are prone to recurrence, and some cases are almost unhealed throughout their lives. In addition, patients with psoriasis are prone to other diseases, such as psoriatic arthritis, anxiety and depression, lymphoma, and metabolic syndrome, which have a great impact on the physical health and mental status of patients. [0003] Although the...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P17/06
CPCA61K31/519A61P17/06
Inventor 周渭胡蒙蒙藏小豪刘起发李尤胡锦荣
Owner GUANGDONG UNIV OF TECH
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