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Natural product combination for treating hemorrhoid and preparation method thereof

A technology of natural products and compositions, which can be used in drug combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the problems of long clinical treatment cycle, side effects, and low possibility of cure.

Active Publication Date: 2019-11-05
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Today, suppositories and ointments containing local anesthetics, steroids, and antihistamines are commonly used as pharmaceutical preparations for rectal and anal diseases, but administration of local anesthetics or topical steroids often causes delay in wound healing and may occur systemic side effects
[0004] At present, the common natural product type topical hemorrhoid drugs on the market are mainly formulated with carrageenate as the main component. The role of carrageenate in the formula is to form a protective layer to protect the damaged mucous membrane. The main therapeutic effect is in the formula. Zinc oxide and titanium dioxide, although this formula has a certain anti-itch and antibacterial effect, but the clinical treatment cycle is long, especially for patients with severe hemorrhoids, and the possibility of cure is low

Method used

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  • Natural product combination for treating hemorrhoid and preparation method thereof
  • Natural product combination for treating hemorrhoid and preparation method thereof
  • Natural product combination for treating hemorrhoid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Raw materials: 2 parts of luteolin, 1 part of luteolin-7-O-β-D-glucuronide, 1 part of Humulus volatile oil Preparation method:

[0033] Add the volatile oil of Humulus japonicus to glycerin, mix and set aside. Take an appropriate amount of polyethylene glycol 6000 and polyethylene glycol 400, heat and melt on a water bath, then slowly add glycerin containing volatile oil of Humulus japonicus, luteolin and luteolin-7-O-β under stirring -D-glucuronide, then add cosolvent polysorbate-80, fully mix, quickly pour into the plug mold that has been coated with liquid paraffin, cool and scrape, take out the package, and obtain the hemorrhoid suppository of Example 1 , about 2.0g per capsule, containing about 0.2g of the main ingredient.

Embodiment 2

[0035] Raw material: 4 parts of luteolin, 2 parts of luteolin-7-O-β-D-glucuronide, 2 parts of Humulus volatile oil Preparation method:

[0036] Add the volatile oil of Humulus japonicus to glycerin, mix and set aside. Take an appropriate amount of polyethylene glycol 6000 and polyethylene glycol 400, heat and melt on a water bath, then slowly add glycerin, luteolin and luteolin-7-O-β containing the volatile oil of Humulus japonicus while stirring -D-glucuronide, then add cosolvent polysorbate-80, fully mix, quickly pour into the plug mold that has been coated with liquid paraffin, cool and scrape, take out the package, and obtain the hemorrhoid suppository of Example 1 , about 1.9g per capsule, containing about 0.3g of the main ingredient.

Embodiment 3

[0038] Raw materials: 5 parts of luteolin, 3 parts of luteolin-7-O-β-D-glucuronide, 3 parts of Humulus volatile oil Preparation method:

[0039] Add the volatile oil of Humulus japonicus to glycerin, mix and set aside. Take an appropriate amount of polyethylene glycol 6000 and polyethylene glycol 400, heat and melt on a water bath, then slowly add glycerin, luteolin and luteolin-7-O-β containing the volatile oil of Humulus japonicus while stirring -D-glucuronide, then add the solubilizing agent polysorbate-80, fully mix, then add and quickly pour into the plug mold that has been coated with liquid paraffin, cool and scrape, take out the package, and obtain the product of Example 1. Hemorrhoid suppository, about 1.8g per capsule, containing about 0.4g of the main ingredient.

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Abstract

A natural product combination for treating hemorrhoid and a preparation method thereof are disclosed. The natural product combination for treating hemorrhoid includes the following ingredients (by weight): 2-7 parts of luteolin, 1-5 parts of luteolin-7-O-beta-D-glucuronide, and 1-5 parts of scandent hop volatile oil. The above natural product combination for treating hemorrhoid can effectively treat external hemorrhoids, internal hemorrhoids, mixed hemorrhoids, hemafecia caused by haemorrhoids and the like, has remarkable curative effect, has mild and non-irritating drug properties, and has noanaphylactic reaction.

Description

technical field [0001] The invention relates to the field of hemorrhoid drugs, in particular to a natural product composition for treating hemorrhoids and a preparation method thereof. Background technique [0002] Hemorrhoids are a common clinical disease. In 2016, the incidence rate of the Chinese population was 59.1%. By 2020, the incidence rate of the population is expected to be more than 70%. Hemorrhoids is a chronic anal disease. There are three main clinical types, including internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids. Blood in the stool is a common clinical symptom of hemorrhoids, which usually manifests as dripping blood, blood in the stool, or to a greater extent Bleeding, which can be aggravated by drinking alcohol or eating irritating foods. At present, the principle of treatment of hemorrhoids is mainly based on non-surgical treatment, and the common non-surgical treatment strategies include oral and external drugs. The current oral drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K9/02A61K47/10A61P9/14A61K31/352A61K31/7048
CPCA61K9/02A61K31/352A61K31/7048A61K36/60A61K47/10A61P9/14A61K2300/00
Inventor 周子晔王陈翔林观样
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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