Cortex eucommiae extract composition for treating gestational hypertension and application of cortex eucommiae extract composition

A pregnancy-induced hypertension and composition technology, applied in the field of traditional Chinese medicine extracts, can solve the problems that the impurities and harmful components of Chinese medicine components cannot be effectively eliminated, the active ingredients have no separation and purification process, and pregnancy-induced hypertension needs to be further improved, so as to improve the quality of the medicine. Useful value, good extraction effect, and effect of improving curative effect

Active Publication Date: 2019-11-26
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Chinese patent application CN 102670791 A discloses a traditional Chinese medicine oral liquid of Eucommia ulmoides for relieving hypertension, which is made of the following raw materials in parts by weight: 150-300 parts of Eucommia ulmoides, 150-300 parts of angelica, 150-300 parts of Morinda officinalis , Polygonum multiflorum 150-300 parts, lotus leaf 150-300 parts, the oral liquid can quickly relieve symptoms such as tinnitus, dizziness, headache, palpitation, shortness of breath, insomnia caused by high blood pressure, but due to the large number of components, there is no effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The Eucommia ulmoides extract composition for treating pregnancy-induced hypertension in this embodiment, in parts by weight, said composition includes: 25 parts of ursolic acid, 15 parts of chlorogenic acid, pinoresinol diglucoside and syringaresin diglucoside 50 parts of mixed extracts of glycosides and 35 parts of total flavonoids;

[0043] The preparation method of the eucommia extract composition for treating hypertension in pregnancy comprises the following steps:

[0044] (1) Take Eucommia ulmoides and grind it to 30 mesh, add it into water with 7 times the mass of Eucommia ulmoides, use a mixture of cellulase and polymethylgalacturonase with a mass ratio of 1:2 to enzymolyze, filter, and obtain the enzymolysis solution and filter residue 1;

[0045] (2) Take the filter residue 1, wash it with petroleum ether, place it in 6 times cold ethanol at 2°C, ultrasonicate at the same temperature, and filter to obtain the alcohol solution 1, add water to the alcohol solu...

Embodiment 2

[0052] The Eucommia ulmoides extract composition for treating pregnancy-induced hypertension in this embodiment, in parts by weight, the composition includes: 40 parts of ursolic acid, 10 parts of chlorogenic acid, pinoresinol diglucoside and syringaresin diglucoside 60 parts of mixed extracts of glycosides and 30 parts of total flavonoids;

[0053] The preparation method of the eucommia extract composition for treating hypertension in pregnancy comprises the following steps:

[0054] (1) Take eucommia ulmoides and crush them to 20 meshes, add eucommia ulmoides to 5 times the weight of water, use a 1:1 mixture of cellulase and polymethylgalacturonase to enzymolyze, filter, and obtain enzymolysis solution and filter residue 1;

[0055] (2) Take the filter residue 1, wash it with petroleum ether, place it in 5 times cold ethanol at 1°C, sonicate at the same temperature, and filter to obtain the alcohol solution 1, add water to the alcohol solution 1, and the precipitated solid ...

Embodiment 3

[0062] The Eucommia ulmoides extract composition for treating pregnancy-induced hypertension in this example, in parts by weight, the composition includes: 20 parts of ursolic acid, 25 parts of chlorogenic acid, pinoresinol diglucoside and syringaresin diglucoside 20 parts of mixed extracts of glycosides and 50 parts of total flavonoids;

[0063] The preparation method of the eucommia extract composition for treating hypertension in pregnancy comprises the following steps:

[0064] (1) Take Eucommia ulmoides and crush it to 40 mesh, add it into water with 8 times the mass of Eucommia ulmoides, use a 1:3 mixture of cellulase and polymethylgalacturonase to enzymolyze, filter, and obtain enzymolysis solution and filter residue 1;

[0065] (2) Take the filter residue 1, wash it with petroleum ether, place it in 8 times cold ethanol at 10°C, ultrasonicate at the same temperature, and filter to obtain the alcohol solution 1, add water to the alcohol solution 1, and the precipitated ...

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Abstract

The invention belongs to the field of traditional Chinese medicine extracts, and particularly relates to a cortex eucommiae extract composition for treating gestational hypertension and an applicationof the cortex eucommiae extract composition. The composition comprises 20-40 parts of ursolic acid, 10-25 parts of chlorogenic acid, 20-60 parts of a mixing extract of pinoresinol diglucoside and liriodendrin, and 30-50 parts of total flavone. The cortex eucommiae extract composition is prepared through the steps of enzymolysis, multiple-step extraction, dissolving and the like. The preparation method is simple and efficient, the prepared cortex eucommiae extract composition has good effect in the respect of treating gestational hypertension, and besides, the side effect is reduced.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extracts, and in particular relates to an extract composition of Eucommia ulmoides for treating pregnancy-induced hypertension and its application. Background technique [0002] Gestational hypertension refers to the symptoms of high blood pressure, edema, proteinuria and other symptoms in women after 20 weeks of pregnancy, which are transient and disappear after delivery. It is a pregnancy-specific disease and is one of the main causes of maternal and perinatal illness and death. Hypertension must be considered if the systolic blood pressure is above 140 mm Hg (18.7 kPa) and the diastolic blood pressure is above 90 mm Hg (12.0 kPa) in the third trimester of pregnancy. There are many theories about the causes of pregnancy-induced hypertension. It is generally believed that certain substances from the placenta enter the maternal blood, causing changes in the immune factors of the pregna...

Claims

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Application Information

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IPC IPC(8): A61K36/46A61K31/56A61K31/216A61K31/7048A61P15/00A61P9/12
CPCA61K31/216A61K31/56A61K31/7048A61K36/46A61K2236/19A61K2236/333A61K2236/35A61K2236/55A61P9/12A61P15/00
Inventor 陈梁李小锋刘厚权夏淑英胡吉忠张俊英张金良周朝忠毛金娣
Owner JIANGXI POZIN PHARMA
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