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Imiquimod for local use on skin

A topical, skin technology, applied in the field of medicine, can solve the problems of complicated preparation steps, easy to be wiped off, and the effect of imiquimod is not long, and achieve the effect of improving the disinfection and sterilization effect.

Inactive Publication Date: 2019-12-13
湖北科益药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a topical imiquimod for skin, which solves the problems that the existing imiquimod does not last long, is easily wiped off, and has complicated preparation steps.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] S1. Select 20 parts of raw materials imiquimod, 12 parts of glycerin, 10 parts of ethanol, 8 parts of boric acid, 7 parts of chrysanthemum, 6 parts of surfactant, 7 parts of gelling agent, 5 parts of honeysuckle, 15 parts of soybean lecithin and deionized 30 parts of water, weigh raw materials respectively according to their weight ratio, surfactant is Tween 20, Tween 21, Tween 40, Tween 60, Tween 61, Tween 65, Tween 80, Tween 81, Tween Wen 85, Span 20, Span 40, Span 60, Span 65, Span 80, Span 83, Span 85, castor oil polyoxyethylene ether or a mixture of two or more, gelled The agent is a mixture of carbomer and gelatin;

[0023] S2. Select the ethanol, boric acid and deionized water weighed in S1, add the ethanol, boric acid and deionized water into the mixing agitator, stir for 6-9min, the speed of the mixing agitator is 200r / min, and the temperature is controlled at 30°C , to obtain a solvent, select the imiquimod and glycerin weighed in S1, fully stir the glycerin ...

Embodiment 2

[0027] S1. Select 25 parts of raw materials imiquimod, 19 parts of glycerin, 15 parts of ethanol, 6 parts of boric acid, 5 parts of chrysanthemum, 3 parts of surfactant, 4 parts of gelling agent, 4 parts of honeysuckle, 13 parts of soybean lecithin and deionized 26 parts of water, take raw materials respectively according to their weight ratio, surfactant is Tween 20, Tween 21, Tween 40, Tween 60, Tween 61, Tween 65, Tween 80, Tween 81, Tween Wen 85, Span 20, Span 40, Span 60, Span 65, Span 80, Span 83, Span 85, castor oil polyoxyethylene ether or a mixture of two or more, gelled The agent is a mixture of carbomer and gelatin;

[0028] S2. Select the ethanol, boric acid and deionized water weighed in S1, add ethanol, boric acid and deionized water into the mixing agitator, stir for 7min, the rotating speed of the mixing agitator is 210r / min, and the temperature is controlled at 40°C to obtain Solvent, select the imiquimod and glycerin weighed in S1, fully stir the glycerin an...

Embodiment 3

[0032]S1. Select 30 parts of raw materials imiquimod, 25 parts of glycerin, 20 parts of ethanol, 3 parts of boric acid, 3 parts of chrysanthemum, 1 part of surfactant, 2 parts of gelling agent, 3 parts of honeysuckle, 9 parts of soybean lecithin and deionized 24 parts of water, take raw materials respectively according to their weight ratio, surfactant is Tween 20, Tween 21, Tween 40, Tween 60, Tween 61, Tween 65, Tween 80, Tween 81, Tween Wen 85, Span 20, Span 40, Span 60, Span 65, Span 80, Span 83, Span 85, castor oil polyoxyethylene ether or a mixture of two or more, gelled The agent is a mixture of carbomer and gelatin;

[0033] S2, select the ethanol, boric acid and deionized water weighed in S1, add ethanol, boric acid and deionized water into the mixing mixer, stir for 9min, the rotating speed of the mixing mixer is 220r / min, and the temperature is controlled at 50°C, to obtain Solvent, select the imiquimod and glycerin weighed in S1, fully stir the glycerin and imiqui...

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PUM

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Abstract

The invention discloses imiquimod for local use on skin. The product is prepared from the following raw materials in parts by weight: 20 to 30 parts of imiquimod, 12 to 25 parts of glycerinum, 10 to 20 parts of ethanol, 3 to 8 parts of boric acid, 3 to 7 parts of chrysanthemum, 1 to 6 parts of a surfactant, 2 to 7 parts of a gelatinizing agent, 3 to 5 parts of honeysuckle flower, 9 to 15 parts ofsoybean lecithin, and 24 to 30 parts of deionized water. The imiquimod is locally used for the skin; a gelatinizing agent, ethanol and boric acid are added; the imiquimod is enabled to be in a latex shape; gelatin can be formed on the surface of the skin after use; the medicine effect can last for a long time and the product does not stick to clothes; honeysuckle flower and chrysanthemum flower extracting solutions are added; the disinfection and sterilization effects of imiquimod are further improved, and side effects are avoided, the imiquimod is prepared into a solvent during preparation, so that the imiquimod can be fully fused with other effective substances, the drug effect can be used for uniformly dispersing the affected part of a patient, and meanwhile, the imiquimod is simple andfeasible in preparation steps and convenient to popularize.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to imiquimod for skin topical use. Background technique [0002] Imiquimod is an imidazoquinoline compound. Is a small molecule immunomodulator. Its mechanism of action in the treatment of external genitalia and perianal warts is unclear. This product has no direct antiviral activity, nor does it cause direct, non-specific cytolytic damage. However, preclinical studies suggest that this product may produce antiviral activity by inducing cytokines including INF-α in the body. Condyloma acuminata, also known as genital warts or venereal warts, is a sexually transmitted disease caused by human papillomavirus. The incubation period is about 3 months, the shortest is 3 weeks, the elderly is more than 8 months, and the average is 3 months. Imiquimod cream can produce immune regulation and indirect antiviral effects, and curb the occurrence of virus invasion and infection. [0003] Ex...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4745A61K36/287A61K36/355A61K47/02A61K47/24A61K47/32A61K47/42A61P31/12A61P31/20
CPCA61K9/0014A61K9/06A61K31/4745A61K36/287A61K36/355A61K47/02A61K47/24A61K47/32A61K47/42A61P31/12A61P31/20A61K2300/00
Inventor 方征远刘毅凌宏飞王虎余致维李旭雯凌济操
Owner 湖北科益药业股份有限公司
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