A disposable pipeline installation system for continuous purification treatment of artificial cerebrospinal fluid

Abstract

The invention relates to the field of lumbar vertebra purification equipment, in particular to a disposable pipeline mounting system for continuous purification treatment of artificial cerebrospinal fluid. The disposable pipeline mounting system comprises a storage device, an infusion volume metering device, a fluid outlet volume metering device, a waste fluid bag and a double-cavity catheter; thestorage device comprises a storage bag for storing the artificial cerebrospinal fluid, a storage fluid connection tube connected with a fluid outlet of the storage bag, and a filter arranged on the storage fluid connection tube and used for filtering the artificial cerebrospinal fluid in the storage fluid connection tube; and one end of a first fluid outlet tube communicates with a fluid inlet ofthe double-cavity catheter, the other end of the first fluid outlet tube communicates with a fluid outlet of a first injection pump through a first fluid outlet one-way valve, and thus the artificialcerebrospinal fluid flows to the double-cavity catheter from the first injection pump. The disposable pipeline mounting system can be matched with existing special artificial cerebrospinal fluid continuous purification equipment, and is applied to in-vitro purification treatment of cerebrospinal fluid of central nervous system diseases causing composition, character and circulatory dynamics changes of the artificial cerebrospinal fluid.

Description

technical field [0001] The invention relates to the field of lumbar spine purification equipment, in particular to a disposable pipeline installation system for continuous purification treatment of artificial cerebrospinal fluid. Background technique [0002] As neurosurgical techniques have improved, the rate of death from primary causes has declined, while death and severe neurologic deficits due to secondary brain damage have remained high. Drug therapy for chronic degenerative neurological diseases and neurological autoimmune diseases has limited efficacy; effective drug delivery methods in the central nervous system are still under investigation; intracranial hypertension, cerebral edema, controlled management of brain injury, rapid decontamination of the internal environment of cerebrospinal fluid, and Issues such as the smooth implementation of local mild hypothermia therapy have become bottlenecks restricting the development of neuroscience and need to be resolved ur...

AI Technical Summary

Problems solved by technology

However, due to the backward material engineering technology at that time, frequent pipeline blockage incidents, and low filter efficiency, the clinical effect was not significant, and it was once neglected.

[0008] In 2001, the team of domestic scholar Professor Wang Yongjun designed and invented a WLCSFPS-777 cerebrospinal fluid purification system (patent number 200520110390.4). Referring to the principle of blood purification equipment, improvements were made in the design of pipelines and filters, but it still belongs to the lumbar spine single chamber Tube drainage and filtration treatment, the incidence of tube blockage is high; and the filter design can only remove cells and macromolecular substances in cerebrospinal fluid, but cannot remove inflammatory mediators, blood lysates, excitatory amino acids and neurotransmitters that actually cause neuropathological damage. and electrolyte acid-base disorders and other small molecule pathological components, so it has not been clinically promoted

However, for the pathological components with complex and diverse components that have not been thoroughly studied, it is difficult to completely remove the pathological components and restore the acid-base balance of the electrolyte; moreover, the composition of the biofilter is high, and the saturated adsorption is difficult to judge

[0010] In 2013, the Americans improved the design of the double-lumen tube in the spinal canal (patent number: US8435204B2), which improved the range and efficiency of filtration and purification, but the purification range is still limited to the spinal canal

[0011] Neurapheresis developed in 2017 TM The double-lumen tube was inserted through the lumbar pool, and the performance of the filter was improved to remove small molecule inflammatory mediators; however, its long lumen only reached the thoracic vertebrae, and the cerebrospinal fluid dynamics of its purification showed that the purification range was limited With the spinal canal below the thoracic spine, and the electrolyte acid-base disturbance remains uncorrectable

[0013] In 2003, the Americans designed a cerebrospinal fluid purification system (patent number: WO03 / 015710A2) that infuses fluid with a catheter placed in the lateral ventricle and drains the cerebrospinal fluid with a catheter placed in the lumbar pool (patent number: WO03 / 015710A2). with complications of ventricular injury

[0014] So far, no safe and efficient artificial cerebrospinal fluid purification equipment and installation pipeline have been developed and applied

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