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Method for identifying Zhengshang Xiaotong plaster

A pain-relieving ointment and injury-correcting technology, which can be used in measuring devices, instruments, scientific instruments, etc., can solve problems such as inability to measure with one label and double-measurement, and inability to effectively control the quality of drugs, saving inspection costs and time, and solving sample adhesion, The effect of stable drug quality

Active Publication Date: 2019-12-20
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art, provide a method for identifying Zhengshang Xiaotong Ointment, and overcome the problems that the existing method cannot be used for one standard and double measurement, and cannot effectively control the quality of medicines

Method used

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  • Method for identifying Zhengshang Xiaotong plaster
  • Method for identifying Zhengshang Xiaotong plaster
  • Method for identifying Zhengshang Xiaotong plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation experimental research of need testing solution

[0042] (1) Selection of extraction solvent

[0043] When the TLC of Angelica dahurica was used to identify the preparation of the test solution, methanol, ethanol, n-butanol, ethyl acetate, ether, chloroform, etc. were used as solvents for the direct extraction of the original method; The viscosity of the sample will stick together when it is peeled off from the backing. It must be divided into small pieces when it is added to the extraction container. Otherwise, it will stick to the upper wall of the container and affect the extraction effect. After the solvent is added, the sample is still small due to cohesion. , the extraction effect is poor during reflux extraction, and only when the medicinal dregs are used for grinding and washing, a large amount of active ingredients will be dissolved. It can be seen that it is not feasible to use different solvents for direct extraction, and it is n...

Embodiment 2

[0068] Embodiment 2: the identification method of Zhengshangxiaotong ointment ointment

[0069] 1. Preparation of the test solution

[0070] Take 5.00g of Zhengshangxiaotong ointment samples (batch numbers 20180601, 20180602, 20180701), take 5.00g of negative control samples without Angelica dahurica, add 15.0g of diatomaceous earth to each, grind and disperse evenly, add 15ml of ammonia water to moisten and seal , placed for 30 minutes, added ether 100ml, ultrasonic treatment for 40 minutes, filtered, the filtrate was evaporated to dryness, and the residue was dissolved by adding 1ml of ethyl acetate as the test solution.

[0071] 2. Preparation of reference solution

[0072] Take an appropriate amount of imperatorin reference substance (batch number: 110826-201415), add chloroform to make a solution containing 1mg per 1ml, and use it as the reference substance solution.

[0073] 3. Preparation of Angelica dahurica reference drug solution

[0074] Take 0.50 g of Angelica d...

Embodiment 3

[0078] Embodiment 3: Adopt the method of the present invention to carry out the identification situation of Angelica dahurica and Rhizoma Chuanxiong simultaneously

[0079] 1. Preparation of the test solution

[0080] Take 5.00g each of Zhengshangxiaotong ointment samples (batch numbers 20180601, 20180602, 20180701), take 5.00g each of the simulated negative control sample without Angelica dahurica and the simulated negative control sample without Rhizoma Chuanxiong, add 15.0g of diatomaceous earth each, grind Disperse evenly, add 15ml of ammonia water to make it moist, seal it tightly, let it stand for 30 minutes, add 100ml of ether, treat it ultrasonically for 40 minutes, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution.

[0081] 2. Preparation of reference solution

[0082] Weigh the appropriate amount of imperatorin reference substance (batch number: 110826-201415) and ferulic acid (batch numbe...

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Abstract

The invention relates to a method for identifying a Zhengshang Xiaotong plaster and the method uses thin-layer chromatography to identify Angelica dahurica and / or Ligusticum wallichii in the Zhengshang Xiaotong plaster, wherein the condition of thin-layer chromatography is to use toluene-ethyl acetate-formic acid having the volume ratio of 18: 6: 0.3 as a developing solvent. The method provided byinvention can simultaneously identify Angelica dahurica and Ligusticum wallichii in the prescription to realize one standard and double test, and can effectively save inspection cost and time.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a method for identifying Zhengshangxiaotong Ointment. Background technique [0002] Zhengshang Xiaotong ointment has the effects of promoting blood circulation and dredging collaterals, reducing swelling and relieving pain, and is used to treat local swelling and pain caused by bruises. The drug is manufactured by traditional classic techniques. All the drugs in the prescription have good synergistic effects. During long-term use, it has been proved to have significant clinical curative effect. The drug is deeply trusted by patients and medical workers. Prescription for Zhengshang Xiaotong ointment: 720g of mulberry skin, 440g of mulberry root, 240g of antler glue, 440g of mulberry leaf, 219g of sumac, 440g of ground beetle, 240g of Dipsacus, 330g of rhubarb, 219g of safflower, 219g of earthworm, 219g of black plum , Guan Phellodendron 660g, Chuanxiong 720g, Angelica dahurica 240g, keel ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/94G01N30/95
CPCG01N30/90G01N30/94G01N30/95
Inventor 吕慧锋张琼谭祥和胡小虎
Owner XIAN CHIHO PHARMA
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