A kind of medical brace coated with hydrogel and its preparation method and application

A hydrogel and brace technology, which is applied in the field of medical devices, can solve problems such as brace wearing discomfort and user skin damage, and achieve the effect of avoiding skin damage and improving comfort

Active Publication Date: 2022-02-08
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, how to solve the problem of wearing the brace uncomfortable and easily causing skin damage to the user has become a technical problem that needs to be solved urgently in this field.

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0028] The preparation method of the medical brace coated with hydrogel of the present disclosure comprises the following steps:

[0029] Step (1): Swelling the polymer material brace. The polymer material brace can be made of commonly used brace materials in this field, such as polyurethane.

[0030] Step (1) can be specifically as follows:

[0031] Soak the polymer material brace in the swelling solution for a period of time. The swelling solution includes a water-insoluble initiator and an organic solvent, and the mass percentage of the water-insoluble initiator is 8-12%. The water-insoluble initiator in the swelling solution is one or more of benzophenone, 4-methylbenzophenone, benzoyl peroxide and azobisisobutyronitrile, and the organic solvent is acetone, ethanol, methanol , one or more of dichloromethane, chloroform, tetrahydrofuran and acetonitrile. Soaking time can be 25-35min.

[0032] During specific implementation, the mass percent content of the water-insolub...

Embodiment 1

[0043] Put the polymer material brace (made of polyurethane) into the swelling solution and soak for 30 minutes. The swelling solution includes 4-methylbenzophenone and tetrahydrofuran, and the mass percentage of 4-methylbenzophenone in the swelling solution is 10%. . The swollen polymer material brace is placed in the polymerization solution, which includes N,N'-dimethylacrylamide, N,N'-methylenebisacrylamide and potassium persulfate, and the polymerization solution The mass percentage of N,N'-dimethylacrylamide in the product is 10%, and the molar ratio of N,N'-methylenebisacrylamide to N,N'-dimethylacrylamide is 0.02:1. The mass ratio of potassium persulfate to N,N'-dimethylacrylamide is 0.01:1. Polymerization was initiated on the surface of the polymer material brace by heating to 70° C. for 30 minutes to form a 3mm hydrogel on the surface of the polymer material brace. The hydrogel is stably combined with the polymer material brace. The hydrogel has the advantages of go...

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Abstract

The invention discloses a medical brace coated with hydrogel and its preparation method and application. The preparation method comprises: performing swelling treatment on the polymer material brace; placing the swollen polymer material brace on In the polymerization liquid, and initiate polymerization on the surface of the polymer material brace, to form a hydrogel on the surface of the polymer material brace, wherein, the polymerization liquid includes a monomer, a cross-linking agent and a water-soluble initiator, and the monomer is One or more of acrylamide, N,N'-dimethylacrylamide and acrylic acid, the cross-linking agent is N,N'-methylenebisacrylamide, and the water-soluble initiator is I-2925 or persulfuric acid potassium. The preparation method of the hydrogel-coated medical brace of the present invention can form a hydrogel on the surface of the polymer material brace in a coated manner, and the presence of the hydrogel can prevent the brace from directly contacting the skin, thereby The wearing comfort of the brace is improved, and the skin damage of the user is avoided.

Description

technical field [0001] The invention relates to the field of medical devices, more specifically, to a hydrogel-coated medical brace and its preparation method and application. Background technique [0002] External fixation braces are mainly used to fix fractured or damaged long bones on the body surface, and are common braces for trauma treatment. [0003] Currently commonly used external fixation braces include plaster braces and polymer material braces. Plaster braces are cheap, but they are heavy, hard, poorly breathable, poor in comfort, and prone to pressure sores. With the swelling of the limbs, the plaster brace is prone to loosening, the fixation function fails, and it cannot be shaped again. Polymer material braces are usually made of polyurethane, which has the advantages of light weight, high strength, good air permeability, good waterproof performance, convenient shaping, comfort and safety. However, the hardness of the polymer material brace after curing is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/18A61F5/05C08L75/04
CPCC08J7/18A61F5/05C08J2375/04
Inventor 杜传超梁辰祝斌李危石刘晓光
Owner PEKING UNIV THIRD HOSPITAL
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