Lisinopril drops and preparation method thereof

A technology for drops and flavoring agents, applied in the field of lisinopril drops and its preparation, can solve the problems of loss of active ingredients, unsuitable medicine for children or the elderly, inappropriateness, etc. The effect of aging brain cells and delaying skin aging

Inactive Publication Date: 2020-02-07
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after taking the tablet, not only the onset of action is slow, but the bioavailability is low, and the cost is high, the preparation process is cumbersome, and it is easy to cause the loss of active ingredients.
Not suitable for patients who have difficulty taking and swallowing solid oral dosage forms, and solid dosage forms are not suitable for children or the elderly because of the increased risk of choking
The taste of tablets is poor. In addition, the current general tablets or oral liquids only have the effect of lowering blood pressure, and do not have the effect of protecting cardiovascular and cerebrovascular. The effect is relatively single

Method used

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  • Lisinopril drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: A lisinopril drop is prepared by using the following raw materials in parts by weight: 1 part of lisinopril, 1 part of base, 0.1 part of flavoring agent, 0.2 part of fragrance agent, and 0.4 part of auxiliary composition.

[0064] The base is polyethylene glycol. Vegetable oil is ginkgo oil.

[0065] The flavoring agent is sucrose. The aromatic agent is blueberry essence.

[0066] The auxiliary composition in this embodiment includes the following raw materials in parts by weight: 2 parts of tea oil, 0.7 part of fish oil, 0.7 part of grape seed oil, 0.7 part of soybean lecithin, and 1.5 parts of vegetable oil.

[0067] The present invention also provides the preparation method of lisinopril drop, and described drop is capsule, and preparation method comprises the following steps:

[0068] (1) Mix lisinopril and matrix raw materials according to the weight ratio, and stir evenly after mixing;

[0069] (2) Heat the mixture obtained in step (1) to a molte...

Embodiment 2

[0072] Embodiment 2: A kind of lisinopril drop, differs from embodiment 1, adopts the raw material of following parts by weight to make: 1 part of lisinopril, 5 parts of matrix, 2 parts of correctives, 0.25 parts of fragrance part, 0.5 part of auxiliary composition.

Embodiment 3

[0073] Embodiment 3: A kind of lisinopril drop, differs from embodiment 1, adopts the raw material of following parts by weight to make: 1 part of lisinopril, 25 parts of substrates, 4 parts of correctives, 0.45 parts of fragrances parts, 0.7 parts of auxiliary composition.

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Abstract

The invention relates to lisinopril drops and a preparation method thereof. The lisinopril drops are prepared from the following raw materials in parts by weight of 1 part of lisinopril, 1-30 parts ofa substrate, 0.1-5 parts of a corrigent, 0.2-0.5 part of a flavoring agent, and 0.4-0.8 part of an auxiliary composition. The preparation method is simple, the corrigent is added, the lisinopril drops are good in mouth feel, and the prepared drops have the characteristics of being quick in medicine release, quick in effect showing, convenient to take and the like, can achieve good biological availability, can sufficiently develop treatment effects of medicines, contain the auxiliary composition, besides, have the effects of resisting liver tumors, reducing cholesterol, preventing atherosclerosis and the like, can realize the purpose of reducing blood pressure, and besides, have health-care effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a lisinopril drop and a preparation method thereof. Background technique [0002] Lisinopril is a lysine derivative of enalaprilat, which belongs to the third generation of angiotensin-converting enzyme inhibitors. Lisinopril can inhibit the activity of angiotensin-converting enzymes, making angiotensin II and The concentration of aldosterone decreases, leading to peripheral vasodilation and decreased vascular resistance, thereby producing a hypotensive effect, and is mainly suitable for the treatment of essential hypertension. Lisinopril is a drug that can be used alone or in combination with other drugs to treat various degrees of hypertension and renal hypertension. It can also be used alone or in combination with diuretics and digitalis to treat congestive heart failure. [0003] Lisinopril is currently administered in the form of oral tablets. However, after taking the tabl...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/10A61K38/05A61P9/12A61P9/04A61P1/16A61P35/00A61P9/10A61K36/87A61K35/60A61K31/685
CPCA61K9/2018A61K31/685A61K35/60A61K36/16A61K36/48A61K36/52A61K36/82A61K36/87A61K38/05A61P1/16A61P9/04A61P9/10A61P9/12A61P35/00A61K2300/00
Inventor裴雪梅张汉华朱正标陶元明陈茂娟
Owner江苏黄河药业股份有限公司