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Radix aucklandiae extract microemulsion as well as preparation method and application thereof

A technology of extracts and microemulsions, applied in the direction of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve the problems that the preparation process is not mature enough, achieve rapid local drug effects, reduce gastrointestinal irritation, and quickly exert effects

Active Publication Date: 2020-03-06
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Microemulsion is a common dosage form in pharmacy, but the preparation process of traditional Chinese medicine extract microemulsion is not mature enough, and there are no reports and researches on the microemulsion of Cassia sinensis extract

Method used

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  • Radix aucklandiae extract microemulsion as well as preparation method and application thereof
  • Radix aucklandiae extract microemulsion as well as preparation method and application thereof
  • Radix aucklandiae extract microemulsion as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 prepares the extract of woody fragrance and measures the content of its active ingredient

[0028] Preparation of woody extract: Grind and sieve the medicinal materials of Cinnamomum sinensis, soak in 6 times the amount of 90% ethanol at 60°C for 1 hour, extract three times, combine the extracts, concentrate, and dry to obtain the Cinnamomum sinensis extract, and measure the extract yield, Contents of corylidene and dehydrocoylidene. Among them, the yield of the extract of the woody extract, the content of the woody hydrocarbon lactone and the dehydrowoody lactone are shown in Table 1.

[0029] Table 1 The yield of extract from Cinnamomum sinensis extract, the content of cassia lactone (CE) and dehydrocassia lactone (DE) in the extract (n=3)

[0030]

[0031] Among them, CE wt% refers to the content of coylidene (CE) in the extract; DE wt% refers to the content of dehydrocoylidene (DE) in the extract.

Embodiment 2

[0032] The selection of each composition in the microemulsion of embodiment 2 woody extracts

[0033] 1. Determination of the solubility of coylin and dehydrocorylide in various excipients in coriander extract

[0034] Take about 2mL of different oil phases, surfactants, and co-surfactants in a stoppered graduated test tube, add excess Cassia sinensis extract, shake in a constant temperature shaking box at 37°C for 48h, 10000r·min -1 Centrifuge for 15 minutes, take the supernatant and dilute it with methanol in an appropriate amount, then measure the solubility of cressyl lactone and dehydrocressine lactone in various excipients, the results are shown in Table 2-Table 4

[0035] Table 2 Equilibrium Solubility (n=3) of Cinnamomum Lactone and Dehydrocosmolide in Different Oil Phases in C.

[0036] name Concentration of coynelide μg·mL -1

Concentration of dehydrocressin μg·mL -1

Oleic acid 523.07±11.08 1086.61±20.35 Isopropyl myristate 2066...

Embodiment 3- Embodiment 20

[0047] The preparation of embodiment 3-embodiment 20 woody extract microemulsion

[0048] Weigh the oil phase isopropyl myristate, surfactant Tween 80, co-surfactant diethylene glycol monoethyl ether, woody extract, deionized Water, placed at 37°C, 700r·min -1 Stir for 2 hours on a special magnetic stirrer to obtain the microemulsion of the extract of Cinnamomum sinensis.

[0049] Content (n=3) of extractum, oil phase, surfactant, co-surfactant and water in different embodiments of table 6

[0050]

[0051]Take by weighing oil phase isopropyl myristate, surfactant Tween 80 or Span 80, co-surfactant absolute ethanol or diethylene glycol monoethyl ether, wood Aroma extract, deionized water, placed at 37°C, 700r·min -1 Stir for 2 hours on a special magnetic stirrer to obtain the microemulsion of the extract of Cinnamomum sinensis.

[0052] Content (n=3) of extractum, oil phase, surfactant, co-surfactant and water in different comparative examples of table 7

[0053] ...

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Abstract

The invention provides a radix aucklandiae extract microemulsion as well as a preparation method and an application thereof. The radix aucklandiae extract microemulsion provided by the invention is prepared from a radix aucklandiae extract, isopropyl myristate, Tween 80, diethylene glycol monoethyl ether and deionized water. The invention also provides the preparation method of the radix aucklandiae extract microemulsion, which comprises the following steps: 1) proportionally weighing isopropyl myristate, Tween 80, diethylene glycol monoethyl ether, deionized water and the radix aucklandiae extract to prepare a suspension; and 2) uniformly stirring the suspension obtained in the step 1) to obtain the microemulsion. In the microemulsion provided by the invention, the transdermal rates of costunolide and dehydrocostunolide are obviously improved, and compared with an aqueous solution of the radix aucklandiae extract, the permeation enhancing ratio of costunolide and dehydrocostunolide ofthe radix aucklandiae extract microemulsion is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a microemulsion of an extract of cassava, and also relates to a preparation method and application of the microemulsion of an extract of cassava. Background technique [0002] Muxiang is the dried root of Radix Aucklandiae, a plant of the genus Radix Aucklandiae in the Compositae family. It is native to India and introduced and cultivated in Yunnan, China. It is listed as the top grade in "Shen Nong's Materia Medica". Woody or woody-compatible Chinese medicines are mostly used clinically to treat inflammatory diseases such as esophagitis, gastritis, peptic ulcer, rheumatism and rheumatoid arthritis. Modern pharmacological studies have shown that woody and the main components of woody lactone and dehydrowoody lactone have various pharmacological activities such as anti-cancer, anti-oxidation, anti-inflammatory, antispasmodic, etc., but woody lactone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/12A61K47/26A61K47/10A61K36/285A61P29/00A61P1/06A61P21/02A61P1/00A61P1/04A61P19/02A61K31/365
CPCA61K9/1075A61K31/365A61K36/285A61K47/10A61K47/12A61K47/26A61P1/00A61P1/04A61P1/06A61P19/02A61P21/02A61P29/00
Inventor 张静泽李慧敏刘岱琳张莉
Owner 天津市尖峰天然产物研究开发有限公司
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