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Acne-removing composition and application thereof, and acne-removing nanogel emulsion comprising the acne-removing composition

A composition and anti-acne technology, which is applied in the direction of drug combination, cosmetic preparations, skin care preparations, etc., can solve the problems of increasing skin photosensitivity, the course of treatment should not be too long, and bacterial resistance, etc., to achieve good anti-acne Acne effect, suppresses propionibacterium acnes, and accelerates exfoliation

Active Publication Date: 2022-04-19
广东中科卓原生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, retinoic acid will increase the photosensitivity of the skin and make the skin red; long

Method used

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  • Acne-removing composition and application thereof, and acne-removing nanogel emulsion comprising the acne-removing composition
  • Acne-removing composition and application thereof, and acne-removing nanogel emulsion comprising the acne-removing composition
  • Acne-removing composition and application thereof, and acne-removing nanogel emulsion comprising the acne-removing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 plant extract

[0030] Implementation group 1: a water extract of forsythia, prepared by the following method: weigh 100 g of dried forsythia fruit, crush it to obtain a coarse powder; add 600 g of water to decoct twice for 30 minutes each time, filter, and combine the filtrate ; Centrifuge to obtain the supernatant, which is the water extract of forsythia.

[0031] Implementation group 2: a water extract of Wangchunhua, prepared by the following method: Weigh 100g of fresh Wangchunhua flower buds, pulverize to obtain a coarse powder; add 600g of water to decoct twice, each time for 30 minutes, filter, and combine the filtrates ; centrifuge to obtain the supernatant, that is, the water extract of Wangchunhua.

[0032] Implementation group 3: a kind of ethanol extract of holly leaves, prepared by the following method: take 100g holly leaves, dry and pulverize to obtain coarse powder; add 65% (V / V) ethanol aqueous solution 600g, and immers...

Embodiment 2

[0036] Embodiment 2 raw material usability test

[0037] Carry out high and low temperature tests on the raw materials prepared by the implementation group 1-3 to investigate its stability; and the implementation group 1-2 is diluted with water into a 10% aqueous solution, and the implementation group 3 is diluted with PEG-400 into a 10% solution to make Patch test on human body to investigate whether it has potential irritation to human skin.

[0038] High and low temperature test method: Add appropriate amount of preservatives to the raw materials to be tested and put them in 3 sample bottles respectively, place them in -15°C, room temperature, and 45°C respectively, take them out every other week, and observe whether there is any after returning to room temperature If abnormalities such as discoloration and odor change occur, observe continuously for one month.

[0039] Human body patch test method: refer to the human skin patch test method recorded in the "Safety and Tech...

Embodiment 3

[0041] The screening of embodiment 3 plant extracts

[0042] The generation of comedo is mainly related to sex hormone imbalance, pilosebaceous duct blockage, and microbial infection. Xu Guangkun, a professor of dermatology at the Third Affiliated Hospital of Sun Yat-sen Medical University, pointed out that bacteria play a very important role in the process of acne inflammation. There may be some microorganisms on the skin surface and in the sebaceous gland hair follicles, the common ones are Propionibacterium acnes, Staphylococcus epidermidis and Pityrosporum pityrosporum, and Propionibacterium acnes has the greatest relationship with acne inflammation. See: Xu Guangkun. Acne and bacteria [J]. Modern Agriculture, 1998, (7): 29. Therefore, it is of great significance to use Propionibacterium acnes to screen acne-removing raw materials.

[0043] The present invention uses Propionibacterium acnes as the test strain, and screens the plant extracts obtained from the above-mention...

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Abstract

The invention discloses an acne-removing composition, which is characterized in that, the acne-removing composition comprises forsythia extract, walnut spring flower extract and wintergreen extract. It can effectively inhibit Propionibacterium acnes, balance skin oil secretion, accelerate the shedding of stratum corneum cells, loosen keratinocytes accumulated at the opening of sebaceous glands, correct abnormal keratinization of hair follicle epithelium, smooth the excretion of sebaceous gland secretions, and inhibit the formation of acne. The results of crowd trials have confirmed that it has a good acne-removing effect.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an acne-removing composition and its application, and an acne-removing nano gel emulsion comprising the acne-removing composition. Background technique [0002] Acne, commonly known as "acne", scientific name "acne". Medically defined as a chronic inflammation of the pilosebaceous glands, it is one of the most common diseases in cosmetic dermatology. It usually occurs on the face, neck, chest, back, shoulders, and upper arms. All age groups can have the disease, and it is more common in puberty, so it is commonly called "acne". [0003] The cause of acne is closely related to factors such as excessive sebum secretion, pilosebaceous gland duct blockage, bacterial infection and inflammatory response. It can be summarized as three points: first, sex hormone imbalance, pilosebaceous duct blockage. After entering puberty, the level of androgens in the human body, especially testosterone, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/04A61Q19/00A61Q17/00A61P17/10
CPCA61K8/9789A61K8/042A61Q19/00A61Q17/005A61Q19/008A61P17/10A61K2800/5922A61K2800/82
Inventor 谢云波张楚东
Owner 广东中科卓原生物科技有限公司
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