Method for preparing tetrandrine from stephania tetrandra total alkali

Abstract

The invention discloses a method for preparing tetrandrine from a stephania tetrandra total alkali extract. The method comprises the steps of sample mixing, column packing, sample loading, separation,purification and the like. According to the method, neutral alumina column chromatography is used, cyclohexane-ethyl acetate is used as an eluent for elution, and tetrandrine in the stephania tetrandra total alkali extract is rapidly obtained; a column chromatography filler used in the method can be repeatedly used, and the used eluent can be recycled, so that the method has the advantages of environmental protection, simple operation, high purity of the obtained tetrandrine, and suitableness for industrial production. The purity of the tetrandrine prepared by the method for preparing the tetrandrine from the stephania tetrandra total alkali extract is more than or equal to 99%.

Description

technical field

[0001] The invention relates to the field of extraction of effective plant components, in particular to a method for preparing tetrandrine from total alkaloids of tetrandrine. Background technique

[0002] Fangji powder, a traditional Chinese medicine, has been used in China for thousands of years. Fenfangji (also known as Fangji) is the dried root slice of Stephania tetrandra S. Moore in the family Fangjiaceae. Alkaline (tetrandrine), tetrandrine base (tetrandrine, fangehinoline), tetrandrine, in addition to flavonoid glycosides, phenols, organic acids, volatile oils, etc. Studies have shown that tetrandrine and tetrandrine have analgesic, anti-inflammatory, blood pressure-lowering, anti-tumor, and striated muscle relaxation effects. In recent years, studies have found that tetrandrine also has anti-arrhythmic effects.

[0003] The active ingredients of Tetrandrine are alkaloids, mainly Tetrandrine and Tetrandrin. Currently, the pharmacological effects of T...

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