59 results about "Stephania tetrandra" patented technology

The invention discloses a tetrandrine biosynthesis-related CYP450 enzyme as well as a biological material and application thereof. The name of the CYP450 enzyme to be protected is CYP82BC1, the CYP450 enzyme is derived from stephania tetrandra, and the amino acid sequence of the CYP450 enzyme is a sequence 2 in a sequence table. According to the invention, microsome extracting solutions of CYP82BC1 and CYP80Q4 proteins are extracted to carry out three groups of substrate enzymatic reactions, and compared with a CYP80Q4 enzyme independent catalytic reaction, the CYP82BC1 can catalyze a catalytic product of the CYP80Q4 enzyme to continue cyclization to generate the cyclized bisbenzylisoquinoline alkaloid. The method can be applied to biosynthesis of cyclized bisbenzylisoquinoline alkaloid and / or an effective component tetrandrine of stephania tetrandra and breeding of stephania tetrandra.

The invention discloses a method for extracting tetrandrine in stephania tetrandra, which comprises the following steps: (1) mixing stephania tetrandra and ethanol, extracting, collecting filtrate, and removing ethanol to obtain stephania tetrandra extract; (2) mixing organic matters, inorganic salts and water to obtain an aqueous two-phase system; and (3) adding the stephania tetrandra extract into the aqueous two-phase system, and then carrying out ultrasonic treatment, shaking extraction and centrifugation to obtain an upper-phase system and a lower-phase system which contain tetrandrine. According to the method for extracting the tetrandrine in the stephania tetrandra, an aqueous two-phase extraction method and an ultrasonic technology are combined, the extraction rate of the tetrandrine in the stephania tetrandra is taken as a target, and an extraction and separation process of the tetrandrine in the stephania tetrandra extract is optimized by adopting the aqueous two-phase extraction method. The tetrandrine extracted by the ultrasonic-assisted aqueous two-phase method is high in yield and low in solvent residue. The extract obtained by the method has a good inhibition effect on pancreatic lipase.

The invention discloses a CYP450 enzyme CYP80Q4 participating in biological synthesis of stephania tetrandra alkaloid and application of the CYP450 enzyme CYP80Q4. According to the technical scheme, the cytochrome P450 enzyme from stephania tetrandra is applied to catalysis of a C-O coupling reaction of a compound to generate bisbenzylisoquinoline alkaloid, the name of the protein is CYP80Q4, and the amino acid sequence is a sequence 2 in a sequence table. After a CYP80Q4 gene is expressed in yeast, a microsome extracting solution containing CYP80Q4 protein is extracted, substrates are screened through a substrate spectrum enzymatic reaction, and 10 groups of obtained substrates can be subjected to a C-O coupling reaction under the catalysis of CYP80Q4 enzyme to generate the bisbenzylisoquinoline alkaloid. The method can be applied to the biosynthesis of the dibenzylisoquinoline alkaloid and / or the effective component tetrandrine of the stephania tetrandra, and the breeding of the stephania tetrandra.

The invention discloses a preparation method and application of a repairing and soothing composition. Aiming at the dissolvability difference of different components in the three extracts, a step-by-step combined extraction process is adopted for extraction, that is, stephania tetrandra is subjected to composite enzymolysis and then subjected to microwave-assisted extraction, citrus peel is subjected to low-temperature fermentation and then subjected to subcritical water extraction, and pogostemon cablin leaves are subjected to supercritical CO2 extraction and then subjected to ethanol gradient elution. After the three extracts extracted by the process are compounded, the composition has excellent skin barrier repairing, moisturizing and skin relieving effects, is safe and non-irritant, and can be used for uncomfortable skin after medical beauty and season change.

The invention relates to the technical field of raw materials of skin care products, and particularly discloses a preparation method and application of an oil-soluble composition for relieving, resisting inflammation and scavenging free radicals. The preparation method of the oil-soluble composition for relieving, resisting inflammation and scavenging free radicals comprises the following steps: step 1) mixing stephania tetrandra, oenothera biennis, hyssopus officinalis, centella asiatica and artemisia apiacea to obtain a composite plant raw material; 2) mixing the composite plant raw material with an extraction solvent, soaking, extracting, filtering, and taking filtrate; 3, the filtrate is subjected to molecular distillation to separate and extract the solvent, distillate is collected, and the soothing, anti-inflammatory and free radical scavenging oil-soluble composition is obtained.The soothing, anti-inflammatory and free radical scavenging oil-soluble composition has the advantages that the free radical scavenging effect is further improved, and a more remarkable anti-aging effect is provided for skin care products.

The invention provides a traditional Chinese medicine external application composition for treating gastroparesis after brain injury and a preparation method thereof. The traditional Chinese medicine external application composition is prepared from the following components: rhizoma acori graminei, paederia scandens, radix polygoni multiflori preparata, aloe, gastrodia elata, semen aesculi, phyllanthus emblica, stephania tetrandra, turmeric, radix fici simplicissimae, fructus piperis longi, swertia pseudochinensis, rhizoma nardostachyos, lily, ginkgo leaves and cynanchum paniculatum. Dual mechanisms of neuroprotection and gastrointestinal motility regulation are creatively fused, central nervous injury can be improved through components such as rhizoma acori graminei and radix polygoni multiflori preparata, gastrointestinal hormone secretion and slow-wave pace-making functions can be synchronously regulated through components such as paederia scandens and turmeric, and compared with a conventional single-target treatment means, the traditional Chinese medicine composition is more suitable for a complex pathological mechanism of gastric paralysis after brain injury. Meanwhile, the preparation process is simple, the cost is low, external application avoids aggravation of gastrointestinal burdens, common western medicine side effects such as arrhythmia are avoided, clinical operation is convenient, patient tolerance is good, the gastric emptying recovery time is remarkably shortened, and the risk of complications such as aspiration pneumonia is reduced.

This invention discloses a medicinal mud for treating blood stasis and heat-induced arthralgia, its preparation method, and its application. The medicinal mud is composed of the following raw materials in parts by weight: 30-70 parts of *Hedyotis diffusa*, 30-70 parts of *Caesalpinia sappan*, 30-70 parts of *Gardenia jasminoides*, 30-70 parts of *Rheum palmatum* (processed with wine), 15-45 parts of *Stephania tetrandra*, 10-30 parts of *Sparganium stoloniferum*, 10-30 parts of *Curcuma zedoaria*, 10-30 parts of *Ligusticum chuanxiong*, 10-30 parts of *Smilax glabra*, 10-30 parts of *Geranium wilfordii*, 10-30 parts of *Polygonum cuspidatum*, 5-15 parts of *Cinnamomum cassia*, 5-15 parts of *Cyperus rotundus*, and 5-15 parts of *Citrus reticulata* (green tangerine peel). The above-mentioned treatment method scientifically combines a large number of heat-clearing, blood-cooling, and detoxifying herbs such as gardenia bark, rhubarb, Japanese knotweed, and smilax glabra with powerful blood-breaking and stasis-removing herbs such as sparganium rhizome, turmeric rhizome, sappanwood, and sclerotium tsao-ko. It is also supplemented with herbs that dispel dampness, unblock the meridians, promote qi circulation, and relieve pain. This method directly targets the three core elements of "blood stasis and heat arthralgia": "heat," "stasis," and "congestion." It treats internal diseases from the outside, with significant curative effects, and avoids the systemic toxic side effects of oral medications.

The invention discloses an anti-allergy soothing composition and a preparation method and application thereof.The anti-allergy soothing composition is prepared from, by mass, 15%-30% of basic carriers and 70%-85% of plant active ingredients, and the plant active ingredients are prepared from, by mass, 15-30 parts of radix stephaniae tetrandrae, 5-15 parts of radix gentianae, 15-20 parts of Chinese herbaceous peony and 10-15 parts of fructus kochiae; 5 to 10 parts of perilla frutescens; according to the preparation method of the anti-allergy soothing composition, plant active ingredients are extracted in a pressurizing, heating and pressure maintaining extraction mode. According to the composition, the stephania tetrandra, the radix gentianae, the Chinese herbaceous peony, the fructus kochiae and the purple perilla serve as plant active ingredients of the anti-allergy soothing composition, the synergistic effect is achieved in the anti-allergy soothing aspect, the rapid anti-allergy soothing effect is achieved, and meanwhile the basic carrier is matched so that moisturizing and barrier repairing can be enhanced.

The application belongs to the technical field of cosmetics, and particularly relates to a redness-reducing and repairing plant extract composition as well as a preparation method and application thereof. The preparation method of the plant extract composition comprises the following steps: (1) freeze-grinding dried leaves of Rehmannia glutinosa, rosemary, oat kernels, peppermint and radix Stephaniae tetrandrae after soaking in warm water to obtain plant raw material powder; (2) adding the obtained plant raw material powder into deionized water, then adding hydroxypropyl cyclodextrin and glycerophosphoinositol choline salt as auxiliary extractants, stirring and extracting at a temperature of 20-50 DEG C, filtering and sterilizing after concentration to obtain an extract; and (3) diluting the obtained extract with a mixed solvent of butanediol and hexanediol, then adding a preservative and uniformly mixing to obtain the redness-reducing and repairing plant extract composition. The hydroxypropyl cyclodextrin and glycerophosphoinositol choline salt are used for low-temperature auxiliary extraction of the plant raw material, which can significantly improve the soothing, redness-reducing and repairing effects of the obtained plant extract composition.

The invention relates to a traditional Chinese medicine composition for treating rheumatic bone pain and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating rheumatic bone pain is prepared from the following raw materials: radix aconiti, radix aconiti agrestis, alpine yarrow herb, ardisia crenata, akebiaquinata, pawpaw, garden balsam stem, eucommia ulmoides, ligusticum chuanxiong hort, radix saposhnikoviae, radix stephaniae tetrandrae, caulis spatholobi, lycopodium clavatum, radix clematidis and radix bupleuri. The traditional Chinese medicine composition disclosed by the invention has the treatment effects of clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, and warming channels and relieving pain, is mainly used for treating gout, waist and knee crymodynia, rheumatic arthritis, numbness of limbs and the like, and has relatively high effective rate.

The invention provides a natural herbal compound factor with a bidirectional immune skin care function and a preparation method thereof, and relates to the technical field of skin care product processing, the natural herbal compound factor comprises 1.2-3.5 parts by weight of a gentiana macrophylla extract, 0.9-2.8 parts by weight of a gentiana scabra bunge extract, 0.8-2.2 parts by weight of a swertia bimaculata extract, (a) a screen protection synergist, (b) a natural stabilizer, and (c) a solvent, the (a) is prepared from 0.6-1.8 parts by weight of stephania tetrandra extract, 1.8-4.5 parts by weight of oat extract, 0.9-2.7 parts by weight of phellinus linteus extract, 0.4-1.8 parts by weight of gardenia extract and 0.8-3.2 parts by weight of paeonia lactiflora pall extract.According to the present invention, the stirring blade assembly and the spiral separation plate with the flow guide groove are arranged, and the spiral separation plate can rotate along with the water vapor so as to achieve the stirring effect; and the stirring blade assembly is driven to synchronously rotate in the heating and purifying tank, so that foam generated by bumping of liquid in the heating and purifying tank is directly and physically eliminated, and raw material loss caused by foam overflow or loss of the extracting solution is effectively avoided.

The invention discloses a traditional Chinese medicine external application formula for adjuvant treatment of bone fracture, a pharmaceutical preparation and application, the traditional Chinese medicine external application formula is prepared from the following raw material medicines by weight: radix clematidis, white mulberry root-bark, safflower, radix stephaniae tetrandrae, lycopodium clavatum, beautiful sweetgum fruit, gentiana macrophylla, divaricate saposhnikovia root, angelica sinensis, radix angelicae, pawpaw, vinegar-processed corydalis tuber, poria peel, processed frankincense and processed myrrh. The in-vitro shock wave treatment and the external prescription are used for treating the patient with plantar fasciitis, and compared with single in-vitro shock wave treatment, the combined use of the in-vitro shock wave treatment and the external prescription can better reduce the level of inflammatory factors, relieve pain and accelerate the disappearance of symptoms and signs.

The invention relates to the technical field of skin care products, and particularly discloses soothing, tightening and anti-wrinkle essence lotion and a preparation method thereof. The soothing, tightening and anti-wrinkle essence lotion comprises the following components: a solvent, a humectant, a composite plant extract, an antibacterial agent, an anti-aging agent and an auxiliary agent, the composite plant extract is prepared by compounding a wild soybean seed extract, a crocus sativus flower extract and a stephania tetrandra extract. The soothing, tightening and anti-wrinkle mask has the advantage of more remarkable soothing, tightening and anti-wrinkle effects.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic nephritis and a preparation method and application thereof. The traditional Chinese medicine composition for treating chronic nephritis is prepared from the following raw materials in parts by weight: radix angelicae sinensis, roasted rhizoma atractylodis macrocephalae, radix stephaniae tetrandrae, radix saposhnikoviae, poria cocos, herba epimedii, fructus rosae laevigatae, radix astragali and rhizoma curcumae. After a chronic nephritis patient is treated by the traditional Chinese medicine composition, indexes such as serum creatinine and 24-hour urine protein can be remarkably improved, clinical symptoms are remarkably relieved, and a better product is provided for treating the chronic nephritis patient.

This invention belongs to the field of cosmetic technology, specifically relating to a moisturizing and anti-wrinkle composition and its application. The moisturizing and anti-wrinkle composition provided by this invention is formulated from Cordyceps sinensis extract, Bifida ferment lysate, Stephania tetrandra extract, Butcher's broom root extract, and complex peptides in a specific ratio. Experiments show that this moisturizing and anti-wrinkle composition can promote the content of type I collagen by up to 162% and scavenge DPPH free radicals by up to 96%, demonstrating significant collagen synthesis-promoting and antioxidant capabilities, thus proving that the composition has good antioxidant and anti-aging effects. Adding this moisturizing and anti-wrinkle composition to an emulsion can significantly improve the TEWL value improvement rate, R0 improvement rate, R2 improvement rate, and wrinkle improvement rate of the emulsion. This indicates that the emulsion can significantly improve the skin barrier's moisturizing and repair capabilities, enhance skin elasticity and firmness, and effectively reduce wrinkles.

The invention discloses a traditional Chinese medicine active extract for preventing and treating asparagus stem blight and a preparation method thereof, and belongs to the technical field of crop planting, the traditional Chinese medicine active extract is prepared from the following raw materials in parts by weight: 20-30 parts of sweet wormwood, 15-20 parts of radix scutellariae, 15-25 parts of rhizoma smilacis glabrae, 8-12 parts of radix sophorae flavescentis, 9-17 parts of radix stephaniae tetrandrae, 2-5 parts of perilla frutescens, 10-15 parts of folium isatidis, 8-10 parts of cyrtomium fortunei and 3-5 parts of indigo naturalis. The preparation method comprises the following steps: crushing the raw materials, uniformly mixing, adding an ethanol solution, carrying out ultrasonic extraction, carrying out aerobic fermentation on the obtained extracting solution, finally carrying out evaporation concentration on the obtained fermentation solution, and carrying out spray drying to obtain the traditional Chinese medicine active extract. According to the invention, various Chinese herbal medicine raw materials are carefully selected, the ratio is optimized, and the processes of crushing, mixing, ethanol ultrasonic extraction, aerobic fermentation, spray drying and the like are combined, so that active components are effectively extracted. An efficient and natural solution is provided for preventing and treating the asparagus stem blight.

The application discloses a skin care composition for improving skin redness and dryness and application. The composition of the application is compounded by hyaluronic acid lysine copper chelate, radix stephaniae tetrandrae extract and polygonatum extract. The composition can promote the expression of moisture retention related factors HAS1 and AQP3, and inhibit the expression of inflammation related factors PGE2 and TNF-alpha, so as to improve the skin redness and dryness. The composition is used in acid mud film, and the stability experiment shows that the composition can maintain the stability of the mud film product under low pH conditions, and the appearance is uniform. It is also found that the composition can greatly reduce the irritation of the acid mud film.

This invention discloses a herbal plant extract firming, anti-wrinkle, and lifting freeze-dried powder and its production process, belonging to the field of cosmetic technology. Mannitol, trehalose, and water are added to an emulsifying pot and stirred until dissolved. Then, the following are added sequentially to the emulsifying pot: Lactobacillus / ginseng root fermentation product filtrate, soluble collagen, gentian root extract, tremella polysaccharide, hydrolyzed collagen, carnosine, Ganoderma lucidum extract, saffron flower extract, dragon's blood extract, centella asiatica extract, sodium hyaluronate, dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8, Stephania tetrandra extract, arginine / lysine polypeptide, and water. The mixture is stirred and cooled, then discharged, packaged, and placed in a freeze dryer. After cooling, a vacuum is drawn, and the mixture is then heated sequentially. The vacuum is released and cooled to room temperature. The powder is then removed, capped, inspected, and stored. This invention freeze-dries various herbal extracts, producing a freeze-dried powder that firms the skin, has good anti-wrinkle effects, provides rich nutrients to the skin, exhibits excellent stability, and is highly safe to use.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating gouty arthritis and a preparation method and application of the traditional Chinese medicine composition and the traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from, by mass, 2.5-5% of herba ephedrae, 7-8% of cassia twig, 7-8% of radix aconiti carmichaeli, 7-8% of radix saposhnikoviae, 7-8% of radix stephaniae tetrandrae, 9-9.8% of radix clematidis, 7-8% of scorpio, 7-8% of pawpaw, 11.5-14.8% of radix cyathulae and 7-8% of nidus vespae. 14.5-15.8% of rhizoma dioscoreae septemlobae and 4-5% of radix glycyrrhizae; the traditional Chinese medicine components are used for rapidly relieving red, swollen and hot pain of joints and improving intractable joint pain, stiffness and unfavorable flexion and extension. The traditional Chinese medicine composition has the advantages that the effect of reducing the serum inflammatory factor level of a gouty arthritis patient is obvious, the pain symptom can be effectively relieved, the red, swollen and heat pain of joints can be quickly relieved, and the intractable joint pain, stiffness and unfavorable flexion and extension are improved.

This invention relates to a method for detecting characteristic chromatograms of anti-inflammatory granules or their intermediate extracts, and its application. The anti-inflammatory granules or their intermediate extracts are prepared from the following medicinal ingredients: Astragalus membranaceus, Panax notoginseng, Salvia miltiorrhiza, Paeonia lactiflora, Stephania tetrandra, Alisma plantago-aquatica, Coix lacryma-jobi, Poria cocos, and Achyranthes bidentata. The detection method is high-performance liquid chromatography (HPLC). The HPLC conditions are: an octadecylsilane-bonded silica gel column, acetonitrile as mobile phase A, and phosphoric acid aqueous solution as mobile phase B, with gradient elution. The method of this invention can obtain characteristic chromatograms with high information content and high peak response values. This method can effectively control the key quality attributes of anti-inflammatory granules and is conducive to industrial promotion, which is of great significance for the quality control standards of anti-inflammatory granules.

The invention provides a capparis spinosa extract, a preparation method and application of the capparis spinosa extract in skin care, and relates to the technical field of daily chemicals. The preparation method of the capparis spinosa extract comprises the following steps: S21, taking capparis spinosa seeds, crushing the capparis spinosa seeds, mixing the crushed capparis spinosa seeds with water, performing heating and stirring, and performing pretreatment; s22, performing solid-liquid separation to obtain capparis spinosa seed powder precipitate; s23, taking the radix stephaniae tetrandrae crude polysaccharide, mixing with water, and dissolving to obtain a polysaccharide solution; s24, mixing the capparis spinosa seed powder precipitate with a polysaccharide solution, and performing high-speed dispersion treatment to obtain a crude extract; and S25, filtering the crude extract to obtain the capparis spinosa seed extract. The preparation method is used for obtaining the capparis spinosa extract containing steroid saponin components, and meanwhile, the solubility of the capparis spinosa extract in a water phase is improved.

This application relates to the field of traditional Chinese medicine (TCM) technology, disclosing a TCM compound composition, its preparation method, and its application in treating discogenic low back pain. The TCM compound composition comprises the following components in parts by weight: Astragalus membranaceus 30g, Ligusticum chuanxiong 18g, Angelica sinensis 9g, Rehmannia glutinosa (processed) 18g, Paeonia lactiflora (fried) 18g, Codonopsis pilosula 9g, Bupleurum chinense 9g, Poria cocos 9g, Stephania tetrandra 9g, Aconitum carmichaelii (processed) 9g, and Angelica pubescens 9g. This TCM compound composition improves the metabolism and structural state of multifidus muscle, restores the mechanical stability of spinal segments, reduces the continuous input of abnormal mechanical stimulation from the source, thereby inhibiting the activation of the Piezo1-Netrin-1 axis, reducing vascular and sensory nerve ingrowth, and ultimately resulting in the protection of the cartilaginous endplate structure and improved pain sensitivity.

This invention discloses a Pickering emulsion loaded with Stephania tetrandra extract, prepared by emulsifying an oil phase and an aqueous phase at a mass ratio of 1:2. The oil phase consists of camellia seed oil and Stephania tetrandra extract, with a mass ratio of camellia seed oil to Stephania tetrandra extract of 40:1 to 80:1.5. The aqueous phase is a 0.5% to 1.0% (w / w) aqueous solution of silk fibroin. This invention also discloses a method for preparing the Pickering emulsion described above. Furthermore, this invention discloses the application of the Pickering emulsion described above in the preparation of cosmetics for relieving acute or chronic atopic dermatitis. The Pickering emulsion prepared by this invention avoids irritation to damaged skin, while optimizing the emulsion particle size and achieving long-term sustained release of Stephania tetrandra extract, thus solving the problem of low bioavailability. This emulsion has high safety, excellent biological efficacy, no significant cytotoxicity, and can achieve biphasic regulation of acute and chronic atopic dermatitis.

This invention provides a traditional Chinese medicine composition for treating and / or preventing lung inflammation-related diseases, wherein the herbal extract contains three active components: Scutellaria baicalensis extract, Stephania tetrandra extract, and Glycyrrhiza uralensis extract. This traditional Chinese medicine composition can be used to treat acute lung injury caused by various factors; currently, there is a lack of drugs for this disease in clinical practice, and this composition can fill that gap.

The invention discloses a stephania tetrandra genuine medicinal material characteristic fingerprint construction and identification method which comprises the following steps: S1, preparation of a test solution: extracting a stephania tetrandra genuine medicinal material by using an extraction solvent to prepare the test solution; s2, high performance liquid chromatography detection: performing high performance liquid chromatography detection on the test solution to obtain a fingerprint spectrum of the stephania tetrandra medicinal material; s3, determining characteristic peaks: analyzing the stephania tetrandra medicinal material fingerprint spectrum obtained in the step S2 to obtain common characteristic peaks, and constructing the characteristic fingerprint spectrum of the stephania tetrandra medicinal material. Different components in stephania tetrandra medicinal materials from different producing areas are screened by adopting ultra-high performance liquid chromatography-time-of-flight-mass spectrometry, and the screened different components are subjected to characteristic fingerprint spectrum construction, so that the characteristic fingerprint spectrum of the stephania tetrandra genuine medicinal materials can be rapidly constructed, and the characteristic fingerprint spectrum can be used for identifying the stephania tetrandra genuine medicinal materials, and has a good application prospect. And a reference is provided for clinical application and overall quality control of a genuine medicinal material of the Jiangxi stephania tetrandra.

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 70 to 130 parts of radix angelicae pubescentis, 70 to 130 parts of rhizoma seu radix notopterygii, 70 to 130 parts of radix stephaniae tetrandrae, 170 to 230 parts of herba siegesbeckiae, 130 to 170 parts of rhizoma atractylodis, 70 to 130 parts of cortex phellodendri, 170 to 230 parts of semen coicis, 70 to 130 parts of herba plantaginis, 70 to 130 parts of tetrapanax papyriferus, 70 to 130 parts of radix achyranthis bidentatae and 260 to 340 parts of ramulus mori. The traditional Chinese medicine composition can effectively solve the problems of large side effect, limited treatment effect and relapse after drug withdrawal of the existing medicine.

The invention provides a plant extraction compound factor with anti-inflammatory and anti-allergy functions and a preparation method thereof, and relates to the technical field of skin care product processing, the plant extraction compound factor is prepared from the following raw materials by weight: 8-10 parts of gentiana macrophylla, 5-7 parts of swertia mileensis, 4-6 parts of stephania tetrandra, 6-8 parts of phellinus igniarius, and 7-9 parts of peony. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 5-7 parts of eucommia ulmoides, 4-6 parts of magnolia sieboldii, 6-8 parts of andrographis paniculata and 3-5 parts of polygala tenuifolia, and the plant extraction compound factor is prepared from the following raw materials in parts by weight: 8-10 parts of centella asiatica, 3-5 parts of bamboo shavings, 5-7 parts of fructus forsythiae and 4-6 parts of amur corktree. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 3-5 parts of coreopsis tinctoria, 7-9 parts of liquorice, 2-4 parts of pelargonium graveolens and 3-5 parts of broom leaf Australian tea.

The invention discloses a traditional Chinese medicine composition for treating myocardial fibrosis and a preparation method thereof, and relates to the field of traditional Chinese medicine, and the traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 6-10 parts of radix stephaniae tetrandrae, 10-20 parts of poria cocos, 6-10 parts of cassia twig, 6-10 parts of astragalus membranaceus and 6-10 parts of liquorice. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 9 parts of radix stephaniae tetrandrae, 18 parts of poria cocos, 9 parts of cassia twig, 9 parts of astragalus membranaceus and 6 parts of liquorice. The dry powder capsule is prepared by adopting a low-temperature concentration and spray drying process; the radix stephaniae tetrandrae is powder radix stephaniae tetrandrae, the poria cocos is peeled white poria cocos, the cassia twig is peeled cassia twig, the astragalus membranaceus is raw astragalus membranaceus, and the liquorice is raw liquorice. According to the traditional Chinese medicine composition, heart function indexes (EF and FS) are remarkably improved, the NT-pro BNP level is reduced, myocardial remodeling is effectively reversed, a substantive treatment effect is shown in a myocardial fibrosis model, the advantages of multiple targets and deep intervention are embodied, and a definite pharmacological basis is provided for development of new traditional Chinese medicines.

This invention belongs to the field of traditional Chinese medicine preparation technology, and provides a traditional Chinese medicine composition with anti-inflammatory, swelling-reducing, analgesic, and joint-relieving properties, its preparation method, and its application in the preparation of drugs for treating arthralgia. The method includes the following steps: Smilax glabra, Corydalis yanhusuo (processed with vinegar), and Stephania tetrandra are pulverized, mixed, decocted with water, filtered, the filtrate is concentrated, ethanol is added to precipitate, the supernatant is collected, the ethanol is recovered and concentrated to obtain a water-extracted alcohol-immersed extract, which is then mixed with maltodextrin, wet-granulated, and dried to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition obtained by this invention is based on the principles of promoting joint mobility, reducing swelling and relieving pain. It can significantly inhibit ankle joint swelling in rats with gouty arthritis, improve local inflammatory cell infiltration, and reduce synovial tissue hyperplasia in rats with gouty arthritis.

The present application relates to a kind of multi-effect herbaceous plant composite soothing repair composition and its preparation method, belong to the cosmetic technical field.The present application is by mixing glacial low deuterium water and superoxide dismutase to obtain A component, add D component (specific proportion nicotinamide mononucleotide (NMN) and modified hyaluronic acid microsphere) by the special interaction of the two with low deuterium water, form "triple synergistic carrier system", significantly improve the penetration and stability of active substance;B component is to mix hydroxyl asiaticoside and humectant.Meanwhile, the composite extract prepared by mixing the extract of radix stephaniae tetrandrae, the extract of gentiana and the extract of piper methysticum is C component, after mixing with A, B, D each component, low deuterium water can well carry the active ingredient in plant extract, hydroxyl asiaticoside and humectant in B component are mixed, can give full play to the moisturizing effect.The composition obtained after mixing A, B, C, D component has excellent soothing repair effect.