41 results about "Cyclohexaneacetic acid" patented technology

The invention discloses a method for purifying cabazitaxel. The method comprises the following steps of: obtaining a crystallized sample by taking cabazitaxel with purity over 98% as a start raw material and cyclohexane, ethyl acetate and ethanol as crystallization solvents; filtering, washing and drying the crystallized sample, and dissolving with methanol; adding a proper amount of adsorbent into the methanol solution of cabazitaxel; sufficiently adsorbing the sample by the adsorbent; filtering the sample again, and evaporating the solvent to dryness; and drying, wherein the impurity content of the dried sample in single technology is reduced to below 0.1% according to the high performance liquid chromatography detection. According to the invention, the impurity content of single cabazitaxel synthesis technology is effectively reduced by a separation and purification method combining crystallization and adsorption, and the requirement that the impurity content of single technology of cabazitaxel is lower than 0.1% is met.

A conversion process of gabapentin hydrochloride into gabapentin comprising: a) dissolution of gabapentin hydrochloride in a solvent in which the gabapentin hydrochloride and the gabapentin are completely soluble; and b) subsequent addition of an amine that allows the removal of the chloride ion from the solution containing gabapentin hydrochloride, by precipitation of the hydrochloride of the same amine, leaving the gabapentin in solution in free amino acid form.

The invention relates to an environmentally friendly acrylic resin and a preparation method thereof, especially suitable for processing nail polish, and belongs to the technical field of polymer materials. The raw materials of the acrylic resin include, by weight, a kettle bed material, a mixed dropping material, an initiator 1, an initiator 2 and a diluent; the kettle bed material includes E10P,amyl acetate and n-butyl acetate; the mixed dropping material includes methacrylic acid, methyl methacrylate, styrene, tert-butyl acrylate, hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, butyl methacrylate, butyl acrylate, dicumyl peroxide, 1,1-di(tert-butylperoxy)cyclohexane and the n-butyl acetate; the initiator 1 includes the 1,1-di(tert-butylperoxy)cyclohexane and the n-butyl acetate; the initiator 2 includes the 1,1-di(tert-butylperoxy)cyclohexane and the n-butyl acetate; and the diluent includes the n-butyl acetate. The acrylic resin is high in environmental protection, so that theexistence of substances harmful to human bodies can be completely solved, and the use amount of solvents can be greatly reduced.

Provided is a package of a solid pharmaceutical preparation capable of preventing an unpleasant odor and coloring due to hydrolysis progressing during storage of a solid pharmaceutical preparation containing 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid.A package of a solid pharmaceutical preparation housing a solid pharmaceutical preparation containing 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid includes a PTP package, an adsorbent, and an outer packaging material. The PTP package includes the solid pharmaceutical preparation, a container sheet for housing the solid pharmaceutical preparation, and a cover sheet having gas permeability sealing the solid pharmaceutical preparation. The adsorbent includes at least zeolite. The outer packaging material includes a gastight material to house and seal the adsorbent and the PTP package.

The invention relates to an anti-inflammatory activity part discovered in boat-fruited scaphium seed extract and a preparation method of the anti-inflammatory activity part. The preparation method includes: sequentially extracting boat-fruited scaphium seed extract with cyclohexane, ethyl acetate and n-butyl alcohol, and partially drying the extracted water solution to obtain the anti-inflammatory activity part. Anti-inflammatory activity test of mice ear swelling model caused by dimethylbenzene and celiac seepage model caused by acetic acid shows that the part has evident anti-inflammatory activity.

A process for producing gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from gabapentin hydrochloride salt. In the disclosed process, the gabapentin hydrochloride is converted to gabapentin using an inorganic base, such as barium hydroxide. Gabapentin hydrochloride is converted to gabapentin sulfate which in turn is converted to free base using barium hydroxide. The process is directed to improvement in the manufacture of gabapentin which would be industrially feasible and effective. Gabapentin obtained following the process of the invention is suitable as a drug especially in the treatment of cerebral diseases such as epilepsy.

The invention discloses a gas chromatography-tandem mass spectrometry detection method for clotrimazole residues in animal-derived food. According to the method, the clotrimazole residues in animal muscle, fat and viscera samples are extracted with a cyclohexane / ethyl acetate mixed solvent accelerated solvent, an extracting solution is purified through gel permeation chromatography and then detected in a gas chromatography-tandem mass spectrometry multi-reaction monitoring mode and quantification is conducted through an isotope internal standard method. Under optimized conditions, clotrimazolehas a good linear relationship within the range of 1.0-100 [mu] g / L, the correlation coefficient is 0.9995 and the limit of quantitation of the method is 1.0 [mu] g / kg. The average recovery rate of the method is 76.5%-107.4% and the relative standard deviation is not greater than 6.2%. The method is high in extraction efficiency, good in purification effect, high in sensitivity and good in repeatability and can be used for measuring the residual quantity of clotrimazole in animal muscles, fat and viscera.

The invention discloses an extract of diterpene-containing white flower cacalia seeds, an extracting method of the extract and an application of the extract. The extracting method includes the steps: drying the white flower cacalia seeds, crushing, sieving, extracting by alcoholic solution, and filtering to obtain total white flower cacalia seed alcohol extracting solution; performing decompression and concentration for the total white flower cacalia seed alcohol extracting solution to constant weight to obtain paste; sequentially extracting by cyclohexane and ethyl acetate to obtain an ethyl acetate extract. The ethyl acetate extract is the diterpene-containing white flower cacalia seed extract. The extract verifies that the extract of the white flower cacalia seeds containing ditepenoid compounds has good function of resisting chronic nonbacterial prostatitis. The white flower cacalia seeds are wide in distribution and easily obtained, the extract of the diterpene-containing white flower cacalia seeds is applied to preparation of medicines for preventing and treating chronic prostatitis, and a preparation method is simple and low in cost and meets development requirements of the medicines.

The invention discloses a medical catheter bonding glue and a preparation method thereof, which belong to the technical field of medical instrument glue production. The raw materials of the glue comprise, by mass, 1.03-2.86% of SEBS, 3.14-10% of tackifying resin, and the balance a solvent. The tackifying resin comprises C5 petroleum resin and hydrogenated rosin glyceride, and the solvent comprises cyclohexane, ethyl acetate and cyclohexanone. Proper tackifying resin types are selected in the glue, so that the bonding strength of the glue is improved; cyclohexanone is added into the solvent, so that the lubricity of the medical catheter is improved; the solvent which volatilizes slowly is selected, so that the working life of the glue is greatly prolonged; meanwhile, the solvent selected in the glue has small side effects on human bodies and small harm to bodies of workers.

The invention discloses a method for preparing tetrandrine from a stephania tetrandra total alkali extract. The method comprises the steps of sample mixing, column packing, sample loading, separation,purification and the like. According to the method, neutral alumina column chromatography is used, cyclohexane-ethyl acetate is used as an eluent for elution, and tetrandrine in the stephania tetrandra total alkali extract is rapidly obtained; a column chromatography filler used in the method can be repeatedly used, and the used eluent can be recycled, so that the method has the advantages of environmental protection, simple operation, high purity of the obtained tetrandrine, and suitableness for industrial production. The purity of the tetrandrine prepared by the method for preparing the tetrandrine from the stephania tetrandra total alkali extract is more than or equal to 99%.

The invention provides a synthetic method for 4-tertiary butyl cyclohexaneacetic acid. The synthetic method comprises the steps of: firstly adding sodium hydride into dried tetrahydrofuran; stirring the mixture and reducing the temperature to 0 DEG C; adding triethyl phosphonoacetate and stirring the mixture; adding a tetrahydrofuran solution of 4-tertiary butyl cyclohexanone, and raising the temperature to room temperature and stirring the mixture; then adding obtained 4-tertiary butyl ethyl cyclohexylideneacetate into methanol; then adding raney nickel to react in a hydrogen atmosphere; and finally mixing the 4-tertiary butyl ethyl cyclohexylacetate with an aqueous solution of sodium hydroxide, and heating and stirring the mixture to obtain the 4-tertiary butyl cyclohexaneacetic acid. The method provides the effective method for producing the 4-tertiary butyl cyclohexaneacetic acid. The method is few in step, high in yield, simple in post-treatment such as purification and easy for industrial production and operation.

The invention provides a method for preparing an anti-inflammatory and anti-tumor active ingredient group from liquorice dregs and an application of the anti-inflammatory and anti-tumor active ingredient group. The anti-inflammatory and anti-tumor active ingredient group prepared from the liquorice dregs comprises 13 flavone compounds; and the method for preparing the anti-inflammatory and anti-tumor active ingredient group from the liquorice dregs comprises the following steps: drying liquorice dregs; crushing the liquorice dregs; by using a solvent extracting method, extracting the liquorice dregs by ethanol or methanol; decompressing and recycling an extraction liquor so as to obtain a crude extract; suspending the crude extract by a distilled water so as to obtain an extract suspension; extracting the extract suspension by petroleum ether or cyclohexane and ethyl acetate in sequence; separating an ethyl acetate extract by silica gel column chromatography; eluting the separated ethyl acetate extract by petroleum ether / ethyl acetate or petroleum ether / acetone mixed solvent in a gradient way; separating an obtained fraction by polyamide column chromatography; and eluting the separated fraction by methanol / water or ethanol / water as mobile phase so as to obtain the active ingredient group. The anti-inflammatory and anti-tumor active ingredient group prepared by using the method provided by the invention, has the advantages of explicit composition, effects of suppressing the growth, proliferation and migration of tumor cell, quinone reductase inducing effect, tumor angiogenesis suppressing effect and anti-inflammatory effect.

The invention belongs to the technical field of pivalic acid synthesis, and particularly relates to a pivalic acid synthesis reaction liquid post-treatment method. The post-treatment method of the pivalic acid synthesis reaction liquid comprises the following steps: after the pivalic acid synthesis reaction is finished, adding a compound extraction agent into the reaction liquid for extraction andseparating the extract to obtain a pivalic acid extraction liquid and a raffinate, and rectifying the pivalic acid extraction liquid to obtain a pure pivalic acid product. The compound extraction agent comprises a main extraction agent and a synergistic extraction agent, wherein the main extraction agent is selected from any one or more of dichloromethane, trichloromethane or chlorobenzene, and the synergistic extraction agent is selected from any one or more of cyclohexane, ethyl acetate or isopropyl ether. The post-treatment method of the pivalic acid synthesis reaction liquid produces lesswastewater, greatly reduces the environmental protection pressure, can realize continuous operation, and has the advantages of high efficiency, environmental protection, low energy consumption, low production cost and the like.

Sustained release oral dosage forms of a gabapentin prodrug, 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid, are disclosed. The dosage forms are useful for treating or preventing diseases and disorders for which gabapentin is therapeutically effective.

The invention relates to a preparation method of an environmental-friendly thermosetting acrylic resin and belongs to the technical field of high polymer materials. The preparation method comprises the following raw materials in parts by weight: acetate solvents at the kettle bottom, a mixture of monomers and initiators, namely methyl methacrylate, tert-butyl methacrylate, styrene, n-butyl acrylate, hydroxy-propyl acrylate, acrylic acid, 1,1-di-tert-butyl peroxide cyclohexane and acetate solvents; supplementary initiators comprising 1,1-di-tert-butyl peroxide cyclohexane and acetate solvents;and diluents comprising the acetate solvents. According to the environmental-friendly thermosetting acrylic resin disclosed by the invention, the content of total benzene series in the resin per 1m<3>is less than 5mg. The powder charge coating prepared by adopting the environmental-friendly thermosetting acrylic resin disclosed by the invention has extremely low benzene content, the temperature resistance reaches 220 DEG C or higher, the value of readily oxidizable substances in the coating is greatly reduced, the total amount on an aluminum foil of 300 square centimeters is less than 1.5ml,fluorescence is not detected in the coating, and any heavy metal does not exist.

The invention relates to a hydroxy acrylic resin suitable for heat-reflecting heat-insulating coatings, belonging to the technical field of hydroxy acrylic resin and a preparation method thereof. Including the following raw materials by weight: kettle bottom material: butyl acetate; mixed monomer dropwise addition: methyl methacrylate, n-butyl methacrylate, lauryl methacrylate, hydroxyethyl methacrylate, methacrylic acid tert-butyl ester, n-butyl acrylate, acrylic acid, 1,1‑bis(tert-butylperoxy)cyclohexane, tert-butyl peroxybenzoate, butyl acetate; supplementary materials 1 and 2 are both: 1,1 ‑Bis(tert-butylperoxy)cyclohexane, butyl acetate; diluting material: butyl acetate. No matter what kind of environment or substrate, the present invention has excellent coating film performance and excellent comprehensive performance.

The invention provides a method for preparing ethyl oleate from Lauraceae plants. The method comprises the following steps: washing the Lauraceae plants, airing, drying, and crushing to form powder; carrying out immersing extraction on the powder by using ethanol at normal temperature, filtering, and carrying out reduced pressure vacuum concentration on the obtained filtrate; dissolving the obtained extract liquid concentrate in deionized water, and extracting by using petroleum ether or ethyl acetate; carrying out reduced pressure vacuum concentration on the extracted petroleum ether or ethyl acetate phase, and carrying out gradient elution by adopting a silica gel column with a petroleum ether-ethyl acetate system or a cyclohexane-ethyl acetate system as a mobile phase to increase the proportion of ethyl acetate; carrying out TLC detection to find the target product after the elution, collecting the target product, and carrying out reduced pressure vacuum concentration; and further purifying the finally obtained concentrate by allowing the concentrate to go through the gel column with a chloroform-methanol system as a mobile phase in order to obtain light yellow oil which is ethyl oleate. The method for preparing ethyl oleate has the advantages of simple operation, low cost, and high purity of the obtained product.

Described is a compound capable of reducing or inhibiting (a) the biological activity of branched-chain-aminotransferase-1 (BCAT1) or (b) the expression of the gene encoding BCAT1 for use in a method of treating a neoplasia. A preferred compound is 1-(aminomethyl)cyclohexaneacetic acid (gabapentin).

A process for producing Gabapentin, (1-(anminomethyl)-1-cyclohexaneacetic acid) from Gabapentin hydrochloride salt. In the process the Gabapentin hydrochloride is converted to Gabapentin using inorganic base such as Barium hydroxide. Gabapentin hydrochloride is converted to Gabapentin sulfate which in turn is converted to free base using Barium hydroxide. The process is directed to improvement in the manufacture of Gabapentin which would be industrially feasible and effective Gabapentin obtained following the process of the invention is suitable as a drug especially in the treatment of cerebral diseases such as epilepsy. The above process involves simple steps and avoid the problems of the known art. In particular the process avoids severe conditions and / or complexities and can be readily adopted for industrial application. The process provides for good yield and does not involve lengthy extended process steps. It is cost-effective and can be carried out involving simple ingredients and steps of manufacture.

The invention provides a preparation method of loropetalum chinense extract and application of the loropetalum chinense extract in preparation of products for wound healing, and relates to the technical field of traditional Chinese medicine extraction. The preparation method comprises the following steps: mixing a loropetalum chinense raw material, water and composite biological bacteria, and carrying out enzymolysis to obtain an enzymolysis product; the composite biological bacterium is a mixture of phanerochaete chrysosporium and streptomyces griseus; carrying out gradient alcohol extraction on the enzymolysis product, merging alcohol extracts, extracting with petroleum ether, and concentrating an organic phase to obtain a component 1; the component 1 is adsorbed by macroporous adsorption resin, the resin is washed with deionized water and then eluted with an eluent, 5-35 min eluent is collected, combined and dried, and the component 1 is obtained. The elution phase is a mixture of cyclohexane, ethyl acetate and acetonitrile. The loropetalum chinense extract is prepared through a specific preparation method, and the wound healing effect is remarkably improved.

The invention relates to a hydroxy acrylic resin suitable for a heat reflection heat insulation coating, and belongs to the technical field of hydroxy acrylic resins and preparation methods thereof. The hydroxy acrylic resin comprises the following raw materials in parts by weight: kettle bottom materials: butyl acetate; mixed monomer dropwise adding materials: methyl methacrylate, n-butyl methacrylate, lauryl methacrylate, hydroxyethyl methacrylate, tert-butyl methacrylate, n-butyl acrylate, acrylic acid, 1, 1-bis (tert-butylperoxy) cyclohexane, tert-butyl peroxybenzoate and butyl acetate; a supplementary material 1 and a supplementary material 2: 1, 1-bis (tert-butylperoxy) cyclohexane and butyl acetate; and a blending thinner: butyl acetate. No matter what environment or substrate is, the coating performance is excellent, and the comprehensive performance is excellent.

The invention discloses a method for separating and purifying bergamot lactone from clausena dentata. The method comprises the following steps: S1, preparation of an extract crude product: adding dried branches and leaves of clausena dentata into an ethanol aqueous solution for extraction, filtering, concentrating under reduced pressure to obtain extract, adding water into the extract for suspension, extracting with petroleum ether, and recovering the solvent to obtain an extract crude product, and S2, performing HSCCC separation on the crude extract: taking cyclohexane / ethyl acetate / n-butyl alcohol / methanol / water in a volume ratio of 6: 4: 1: 5: 5 as a solvent system, taking an upper phase as a stationary phase, taking a lower phase as a mobile phase, taking a host rotating speed as 850 r / min and a mobile phase flowing speed as 2 mL / min, after two phases are balanced, feeding a sample, starting to record a chromatogram at the same time, collecting 140min-165min eluent, and performingvacuum concentration until the eluent is dry. The method is simple in step, and the raw material advantages of the clausena lansium are fully utilized.

The invention belongs to the technical field of pivalic acid synthesis, and in particular relates to a post-processing method for a pivalic acid synthesis reaction solution. The post-processing method of the pivalic acid synthesis reaction solution is that after the pivalic acid synthesis reaction is completed, a compound extractant is added to the reaction solution, extracted and separated to obtain a pivalic acid extract and a raffinate, and the pivalic acid is rectified. The acid extraction solution is to obtain the pure product of pivalic acid; the compound extraction agent includes a main extraction agent and a co-extracting agent, and the main extraction agent is selected from any one of methylene chloride, chloroform or chlorobenzene or The co-extracting agent is selected from any one or more of cyclohexane, ethyl acetate or isopropyl ether. The post-treatment method of the pivalic acid synthesis reaction solution of the present invention produces less waste water, greatly reduces the pressure on environmental protection, can realize continuous operation at the same time, and has the advantages of high efficiency, environmental protection, low energy consumption, low production cost and the like.

The invention discloses a method for separating and purifying tocopherol monomers. The method comprises the following steps: diluting natural vitamin E with cyclohexane, and carrying out chromatography treatment by using a first silica gel column, with an eluent comprising cyclohexane, ethanol and n-propanol in a ratio of 100: (0.1-0.3): (1-2); 14 equal parts of elution components are obtained in sequence; the elution components of the Fr3-Fr5, the Fr8-Fr9 and the Fr11-Fr12 are collected; carrying out vacuum concentration on the elution components of Fr8-Fr9 and Fr11-Fr12 to respectively obtain gamma-tocopherol and delta-tocopherol, and carrying out vacuum concentration on the elution component of Fr3-Fr5; carrying out chromatographic treatment by adopting a second silica gel column, directly loading a concentrated solution on the column, collecting an eluent which is cyclohexane-ethyl acetate in a ratio of 100: (70-85), and carrying out vacuum concentration on the eluent to obtain beta-tocopherol; and regenerating the second silica gel column by using cyclohexane, collecting an elution component, and concentrating under reduced pressure to obtain the alpha-tocopherol.

The invention provides a thin-layer chromatography method for identifying mucuna sempervirens and application of the thin-layer chromatography method. The method comprises the following steps: mixing mucuna sempervirens with ethanol, performing ultrasonic treatment, filtering after ultrasonic treatment, evaporating filtrate to dryness, and dissolving residues with ethanol to obtain a test solution; and dripping the test solution and the Mucuna sempervirens reference medicinal material solution on the same thin-layer plate, and carrying out thin-layer chromatography identification by taking cyclohexane-ethyl acetate-formic acid as a developing solvent and taking a sulfuric acid ethanol solution with the volume fraction of 10% as a color developing agent. The thin-layer chromatography method provided by the invention has the advantages of clear sample spot color development and strong durability, can effectively identify Mucuna sempervirens, can distinguish Mucuna sempervirens from Caulis Spatholobi and Mucuna macrocarpa which are similar to the Mucuna sempervirens in appearance property or medicinal material powder, is simple to operate and high in detection efficiency, and can be used for detecting Mucuna sempervirens. The method has a wide application prospect in the quality control and authenticity identification of the mucuna sempervirens medicinal materials.

The invention belongs to the technical field of biomedicine and discloses the application of orange leaf extract in the preparation of medicine for treating / preventing autoimmune orchitis. Using the leaves of citrus which is rich in resources in my country as raw material, the citrus leaf ethanol extract obtained by ethanol cold soaking is then eluted by macroporous resin, and the concentrate of ethanol and acetone eluted parts is combined, dispersed in water, and successively used After extraction with cyclohexane, ethyl acetate and n-butanol, it was concentrated. Pharmacological experiments show that the orange leaf extract has anti-autoimmune orchitis effect, and can be developed into a drug for treating / preventing autoimmune orchitis.

The invention discloses a method for identifying cortex pseudolaricis in a traditional Chinese medicinal compound. The method comprises the following steps: (1) adding a sample onto a polyamide column, eluting with a mixed solution, eluting with an organic solvent A, collecting the eluting liquid, drying by distillation, dissolving residues with the organic solvent to serve as a test-sample solution; (2) treating a cortex pseudolaricis control medicinal material with an organic solvent B, drying the filtrate by distillation, dissolving the residues with the organic solvent B to serve as a control medicinal material solution; and (3) taking 2-6mu L of the test sample solution and 2-6mu L of the control medicinal material solution, respectively applying the solutions to the same silica gel chromatographic sheet, taking a mixed solution of cyclohexane-ethyl acetate as a developing solvent, developing, taking out, drying in the air, and inspecting under a 365nm ultraviolet lamp. The identification method can be used for effectively removing impurities in a sample for test, the main ingredient loss is relatively small, and the chromatogram of the test-sample solution has clear and easily-distinguished spots, application of benzene and other reagent with relatively high toxicity can be avoided. The method has the advantages of high specificity, good repeatability, high sensitivity, environment friendliness and the like.

The invention relates to a method for removing acetic acid from cyclohexane in preparation of cyclohexyl acetate by reactive distillation, and belongs to the field of petrochemical technology development. In the present invention, the mixture of cyclohexene and cyclohexane obtained by partial hydrogenation of benzene is used as a raw material, and in the process of preparing cyclohexyl acetate by reacting with acetic acid in a reactive distillation tower, the water phase at the top of the reactive distillation tower is circulated and refluxed, and combined with Cyclohexane in the tower forms an azeotrope, thereby reducing or eliminating the azeotropy between cyclohexane and acetic acid, and obtaining cyclohexane with an acetic acid content of less than 5wt%; then distilling cyclohexane through a simple azeotropic rectification tower to remove cyclohexane acetic acid in. The invention has simple process, strong parameter controllability, low energy consumption and material consumption, and is convenient for large-scale industrial application.

The application discloses a kind of baijiaocao formula granules thin layer identification method and application thereof, the thin layer identification method includes: test sample powder is dissolved after water is added and is extracted with ethyl acetate, evaporates dry, residue is dissolved with methanol to obtain test sample solution;Take baijiaocao control medicinal material, heat reflux, filter, concentrate, add methanol, ultrasonic, filter, evaporate dry, dissolve with water, extract with ethyl acetate, evaporate dry, residue is dissolved with methanol to obtain control medicinal material solution;Sample is applied to the same thin layer plate, with cyclohexane-ethyl acetate-methanol-formic acid as developing agent, after color development, view;When the same color spot is shown in the corresponding position of test sample chromatogram with control medicinal material chromatogram, then it indicates that test sample is baijiaocao formula granules.The application method can detect multiple components in sample, greatly improve the specificity of method;Can distinguish between yellow flower and white flower baijiaocao;Baijiaocao can be easily distinguished from counterfeit, with higher practical value.