Application of punicalagin in inhibiting growth of multi-drug resistant klebsiella pneumoniae

A Klebsiella pneumoniae, multidrug-resistant technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of less growth of multidrug-resistant Klebsiella pneumoniae, and achieve a solution Drug resistance and infection problems, wide application value, and the effect of reducing mortality

Pending Publication Date: 2020-04-07
SHAANXI UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

However, there are few reports on punicalagin inhibiting

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  • Application of punicalagin in inhibiting growth of multi-drug resistant klebsiella pneumoniae
  • Application of punicalagin in inhibiting growth of multi-drug resistant klebsiella pneumoniae
  • Application of punicalagin in inhibiting growth of multi-drug resistant klebsiella pneumoniae

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Embodiment Construction

[0013] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0014] 1. Drug susceptibility test of human Klebsiella pneumoniae

[0015] The present invention uses multiple strains of human Klebsiella pneumoniae (strain samples taken from Ningbo Center for Disease Control and Prevention) as starting strains, and selects imipenem, meropenem, ertapenem, doripenem, and gentamicin Antimicrobial susceptibility tests were carried out on the strips of 8 commonly used antibiotics, cefotaxime, ciprofloxacin and azithromycin.

[0016] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the plate, and place it at roo...

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Abstract

The invention discloses application of punicalagin in inhibiting growth of multi-drug resistant klebsiella pneumoniae. Punicalagin has a relatively good in-vitro killing effect on multi-drug resistantklebsiella pneumonia and can inhibit the growth of multi-drug resistant klebsiella pneumoniae, and the minimum bactericidal concentration is 3.6 mg/mL and the minimum bacteriostatic concentration is1.8 mg/mL. The invention provides the inhibiting effect of punicalagin on multi-drug resistant klebsiella pneumoniae, and the punicalagin has wide application value in the fields of medicine and the like.

Description

technical field [0001] The invention relates to the research, development and application of punicalagin, an active ingredient of traditional Chinese medicine, as an inhibitor of Klebsiella pneumoniae, in particular to the application of punicalagin in inhibiting the growth of multidrug-resistant Klebsiella pneumoniae. Background technique [0002] Klebsiella pneumoniae (Klebsiella pneumonia) is a common nosocomial infection pathogen and the most important bacterium in the Enterobacteriaceae Klebsiella genus. Klebsiella pneumoniae can cause typical primary pneumonia, as well as various extrapulmonary infections, such as infantile enteritis, meningitis, iatrogenic urinary tract infection in adults, trauma infection and bacteremia. With the widespread use of antibiotics in clinical practice, bacterial drug resistance is becoming stronger and stronger. The emergence of multidrug-resistant Klebsiella pneumoniae has brought great challenges to clinical treatment. [0003] Tradi...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/04
CPCA61K31/7048A61P31/04
Inventor 钱卫东孙照欢王婷沈兰芳杨敏刘淼张家宁王文静
Owner SHAANXI UNIV OF SCI & TECH
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