Puerarin co-crystal of lornoxicam and preparation method thereof

Abstract

The invention discloses a co-crystal of lornoxicam and puerarin, the co-crystal is formed by combining lornoxicam and puerarin at a molar ratio of 1:1, and has a powder X-ray diffraction pattern represented by 2θ angle value , and infrared spectra. The preparation method comprises the steps of: dissolving lornoxicam and puerarin in an organic solvent according to a certain molar ratio, rotating the solvent under reduced pressure, drying in vacuum, and placing it in a resistance furnace to remove the solvent, thereby obtaining lornoxicam puerarin eutectic. The eutectic of the present invention is different from the powder X-ray diffraction and infrared of lornoxicam monomer and puerarin monomer and their physical mixtures, and the crystal form of the eutectic is a new one different from monomers and physical mixtures. Crystal form, improve the compressibility of lornoxicam, and the water solubility of lornoxicam and puerarin.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to lornoxicam puerarin co-crystal and a preparation method thereof. Background technique

[0002] Lornoxicam (Lornoxicam) belongs to the non-steroidal anti-inflammatory analgesics of the Xicam class. Its action sites are mainly in the central nervous system and peripheral pain areas. It has analgesic, anti-inflammatory and antipyretic effects. It is widely used clinically in rheumatic The treatment of diseases such as arthritis and rheumatoid arthritis occupies an important position in non-steroidal analgesic anti-inflammatory drugs, and has a good market development prospect. Its chemical name is 6-chloro-4-hydroxy-2-methyl-3-(2-pyridinecarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine-1,1 - Dioxide, molecular formula C 13 h 10 ClN 3 o 4 S 2 , the structural formula is as follows:

[0003]

[0004] Puerarin is an isoflavone compound extracted from the dried roots of Pueraria loba...

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