Preparation method and application of j-aggregate photothermal nanoagent based on dyes and polymers

A technology of aggregates and block polymers, which is applied in the directions of photodynamic therapy, preparations for in vivo experiments, and medical preparations of inactive ingredients, etc. It can solve the problems of stability, uncertain biological toxicity, etc., and achieve the effect of constant photothermal conversion effect, outstanding photothermal stability, and good therapeutic effect.
CN111053904BActive Publication Date: 2022-07-05NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2022-07-05

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Abstract

The invention relates to a preparation method and application of a J aggregate photothermal nano-agent constructed based on dyes and polymers. The nanophotothermal reagent takes fluoroborondipyrrole dye molecules and high molecular polymers as basic building units, and is co-assembled in an aqueous solution to obtain a J-aggregate nanosolution that can be stably dispersed in the aqueous system. The formation of J aggregates changes the photophysical / chemical properties of the dye molecules, the absorption spectrum is red-shifted by more than 100 nanometers, and the molar extinction coefficient increases significantly, showing a good photothermal conversion effect. Combined with further supramolecular structure remodeling, the morphology of the J-aggregate material is transformed into nanoparticles, the cellular uptake rate of the material is enhanced, and the biological application of the material is better realized. The J-aggregate nanophotothermal material proposed in the present invention has many advantages such as good biocompatibility, high photothermal conversion efficiency, and resistance to photobleaching, and has broad application prospects in the fields of photothermal therapy and photoacoustic imaging.
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Description

technical field

[0001] The invention belongs to the field of nano-biological materials, and in particular relates to a preparation method and biological application of a J-aggregate photothermal nano-material constructed by co-assembly of fluoroborondipyrrole (BODIPY) dye molecules and high molecular polymers. Background technique

[0002] Photothermal therapy (PTT), as an important tumor treatment method, has attracted extensive attention of scientists due to its advantages of less trauma, simple treatment, and quick recovery. In photothermal therapy, photothermal agents convert light energy into heat energy, thereby achieving thermal ablation of tumors. As far as the currently reported photothermal reagents are concerned, the organic small molecule photothermal reagents require a complex synthesis process, making it difficult to obtain photothermal reagents with low toxicity, high thermal conversion efficiency, and near-infrared absorption. Organic small-molecule photothe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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