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Pharmaceutical composition used for preventing and treating dengue virus and preparation method thereof

A technology of dengue virus and composition, applied in the direction of antiviral agents, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of human immune system rejection, decreased tolerance, poor biocompatibility, etc. The effect of strong prevention and inhibition effect, low cost and simple preparation method

Inactive Publication Date: 2020-04-28
广东卫康有害生物防制有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, the existing problems of the medicines for the treatment of dengue fever are: (1) Poor biocompatibility, direct use of traditional Chinese medicine or Western medicine ingredients as drugs for the prevention or treatment of dengue fever virus, some drugs will cause appropriate host reactions in specific practical applications after entering the human body, and it is easy to make the human immune system foreign matter Rejection, decreased tolerance

Method used

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  • Pharmaceutical composition used for preventing and treating dengue virus and preparation method thereof
  • Pharmaceutical composition used for preventing and treating dengue virus and preparation method thereof
  • Pharmaceutical composition used for preventing and treating dengue virus and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0024] The components and mass ratios of a pharmaceutical composition for preventing and treating dengue virus provided by the embodiments of the present invention are: 20 parts of ribavirin, 20 parts of superfine starch granules, 2 parts of concentrated sulfuric acid, benzoyl peroxide Acyl 0.5 parts, water 47.5 parts. A hyperbranched antiviral macromolecule is generated through condensation polymerization, and then compounded with 10 parts of Prunella vulgaris and honeysuckle auxiliary materials to obtain a pharmaceutical composition for preventing and treating dengue fever virus.

[0025] A kind of pharmaceutical composition for preventing and treating dengue fever virus provided by the embodiment of the present invention, its preparation method comprises:

[0026] (1) Add 20 parts of ribavirin, 20 parts of superfine starch granules and 47.5 parts of water into the flask, raise the temperature, stir vigorously at 25°C for 0.5h, and then assisted ultrasonic dispersion for 1h ...

Embodiment 2

[0030] The components and mass ratios of a pharmaceutical composition for preventing and treating dengue virus provided by the embodiments of the present invention are: 30 parts of ribavirin, 20 parts of superfine starch granules, 3 parts of concentrated sulfuric acid, peroxydicarbonic acid 1 part of diisopropyl ester, 41 parts of water. A hyperbranched antiviral macromolecule is generated through condensation polymerization, and then compounded with 5 parts of Prunella vulgaris and mulberry leaf compound auxiliary materials to obtain a pharmaceutical composition for preventing and treating dengue fever virus.

[0031] A kind of pharmaceutical composition for preventing and treating dengue fever virus provided by the embodiment of the present invention, its preparation method comprises:

[0032] (1) Add 30 parts of ribavirin, 20 parts of superfine starch granules and 41 parts of water into the flask, raise the temperature, stir vigorously at 30°C for 1 hour, and then assisted ...

Embodiment 3

[0036] The components and mass ratios of a pharmaceutical composition for preventing and treating dengue virus provided by the embodiments of the present invention are: 50 parts of ribavirin, 20 parts of superfine starch granules, 5 parts of concentrated sulfuric acid, and 2 parts of ammonium persulfate. 13 parts of water. A hyperbranched antiviral macromolecule is generated through condensation polymerization, and then compounded with 10 parts of honeysuckle auxiliary materials to obtain a pharmaceutical composition for preventing and treating dengue fever virus.

[0037] A kind of pharmaceutical composition for preventing and treating dengue fever virus provided by the embodiment of the present invention, its preparation method comprises:

[0038] (1) Add 50 parts of ribavirin, 20 parts of superfine starch granules and 13 parts of water into the flask, raise the temperature, stir vigorously at 35°C for 0.5h, and then assisted ultrasonic dispersion for 1h until the solution i...

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Abstract

The invention discloses a pharmaceutical composition used for preventing and treating dengue virus and a preparation method thereof, and belongs to the technical field of drug preparation. The pharmaceutical composition used for preventing and treating the dengue virus provided by the invention comprises the following raw materials in percentage by mass: 20-50% of ribavirin, 10-30% of ultrafine starch particles, 5-20% of bacterium-resisting and disinfecting auxiliary materials, 1-5% of a condensing agent, 0.1-2% of an initiator, and the balance of water. Drugs in the pharmaceutical compositionconsist of hyperbranched ribavirin polymers and pharmaceutically acceptable accessories, so that the pharmaceutical composition prepared according to the preparation method has strong prevention, treatment and suppression effects on replication of the dengue virus type-I; and moreover, the pharmaceutical composition is mainly prepared into injection, oral liquid or spray.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and relates to a medicine composition for preventing and treating dengue fever virus and a preparation method thereof. Background technique [0002] Dengue virus (dengue virus) belongs to Flaviviridae and Flavivirus genus in classification, including 4 different serotypes, namely dengue virus types I, II, III, and IV. Dengue fever mainly transmits viruses through mosquitoes, invades human cells, and reacts through virus and protein receptors, causing immune system diseases in the human body. Especially in recent years, with the continuous warming of the global climate, the spread of mosquitoes has accelerated and the distribution has become wider, resulting in the rapid spread of dengue fever worldwide. At present, about 50 million to 100 million people in the world are infected with dengue virus every year, and there have been dengue fever occurrences and pandemics in China's Guangdong, Hain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K31/7056A61K47/46A61P31/14
CPCA61K47/61A61K31/7056A61K47/46A61P31/14Y02A50/30
Inventor 陈伟明陈钦荣翁聪聪
Owner 广东卫康有害生物防制有限公司
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