A high-throughput micro-droplet generation device and method controlled by surface acoustic waves

Abstract

A high-throughput micro-droplet generation device and method regulated by surface acoustic waves, the device includes an interdigital transducer, an arc-shaped interdigital electrode is fabricated on the interdigital transducer, and the upper part of the interdigital transducer is bonded with PDMS microchannel system, the PDMS microchannel system is formed by bonding the top PDMS flow channel, the middle layer PDMS flow channel and the bottom PDMS flow channel; the method is to first fix the device on the stage of the microscope, and inject the dispersed phase through the syringe pump. Adjust the corresponding flow rate with the continuous phase. At each T-shaped micro-channel in the device, the continuous phase will cut the dispersed phase into micro-droplets, and then press the "output" button of the signal generator, and the interdigital transducer will Converging surface acoustic waves are generated, and the sound pressure field acts on the continuous phase to increase the corresponding flow resistance, which acts as an acoustic valve to regulate the flow rate of the continuous phase, thereby realizing the regulation of the droplet size; the present invention ensures high-flux generation of droplets while , by adjusting the amplitude and frequency of the input sinusoidal voltage, the generation size of micro-droplets can be flexibly and real-time controlled.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a device and method for generating high-flux microdroplets regulated by surface acoustic waves. Background technique [0002] Microdroplets are widely used in biomedical research and chemical material manufacturing, among which the method of microdroplet generation is very important, and different methods vary greatly in droplet generation rate and uniformity. With the development of microfluidic technology, passive micro-droplet generation methods and active micro-droplet generation methods have emerged. At present, the passive generation methods of micro-droplets mainly include co-flow method, flow convergence method, T-shaped micro-channel method and derivative methods based on the above methods. By adjusting the input pressure of the dispersed phase and the continuous phase, the dispersed phase can be continuously The phase is rapidly sheared into micro-droplets, and t...

AI Technical Summary

Problems solved by technology

[0004] However, in the above methods of acoustically controlled droplet generation, most of the microfluidic devices used are two-dimensional flow channels, and their generation rate is limited to a certain extent, which is not suitable for the generation of large-flux microdroplets, especially when large-scale liquid flow is required. When droplets are generated rapidly, the generation rate is difficult to meet the needs, and a high-throughput microfluidic generation device with active droplet real-time regulation is urgently needed

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