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Application of aqueous extract prepared by traditional Chinese medicine prescription in preparing medicine for treating senile dementia

A technology of senile dementia, water extract, applied in the field of pharmacy

Inactive Publication Date: 2020-05-08
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported whether the Chinese medicine compound water extract CZYH composed of plants Epimedium, Pueraria lobata, Rehmannia glutinosa, etc. can synergistically improve learning and memory impairment in senile dementia patients.

Method used

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  • Application of aqueous extract prepared by traditional Chinese medicine prescription in preparing medicine for treating senile dementia
  • Application of aqueous extract prepared by traditional Chinese medicine prescription in preparing medicine for treating senile dementia
  • Application of aqueous extract prepared by traditional Chinese medicine prescription in preparing medicine for treating senile dementia

Examples

Experimental program
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Effect test

Embodiment 1

[0119] Embodiment 1 of the present invention: the application of the water extract of the Chinese medicine prescription in the preparation of the drug for the treatment of senile dementia. Among them, the mass ratio of sheepskin, kudzu root, rehmannia glutinosa, male silkworm moth, salt plantain seed, wolfberry, poria cocos and coix seed is 5:5:4:4:2:3:4:4; After the ratio is mixed, put it into water that is 8 times the total mass of the drug and soak for 30-60 minutes; decoct the entire soaking liquid and soaked materials with strong fire until boiling, then change to a slow fire and continue to boil for 2 hours, and then filter out the drug with gauze. dregs, take the filtrate for the first time; then add water 6 times the total mass of the drug to the dregs, decoct with strong fire until boiling, then change to a slow fire and continue to boil for 2 hours, then filter out the dregs with gauze, and take the second The second filtrate; then add water 6 times the total mass of...

Embodiment 2

[0121] Embodiment 2 of the present invention: get 5g of water extract of Chinese medicine prescription, 6g of hypromellose, 10g of sodium starch glycolate, 8g of microcrystalline cellulose, 115g of lactose, 50g of starch, 1g of magnesium stearate; After fully mixing with auxiliary materials, it is put into a high-speed mixer, sprayed with an appropriate amount of water, granulated, and the water content is controlled at 3-4%, and then pressed into tablets to make 1000 tablets, coated with film.

Embodiment 3

[0122] Embodiment 3 of the present invention: Take 5g of the water extract of the traditional Chinese medicine prescription, add 400ml of polyethylene glycol 200 to dissolve, then add an appropriate amount of distilled water to dilute, then add an appropriate amount of sucrose and adjust the volume to 1000ml, stir well, filter, and fill Into 10ml or 20ml each, sterilized packaging.

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Abstract

The invention discloses application of an aqueous extract prepared by a traditional Chinese medicine prescription in preparing a medicine for treating senile dementia. Multiple traditional Chinese medicine extracts are combined as a medicine for treating Alzheimer's diseases, animal experiment verifies that the prepared medicine composition has a treatment effect equivalent to that of donepezil and is capable of preventing and treating learning and memory failure, relieving neuron damage, repressing reduction of the number of neurons, and alleviating neuroinflammation and apoptosis reactions in attack of the Alzheimer's diseases. The aqueous extract is wide in material sources, easy to obtain, simple and feasible in medicine preparation and good in treatment effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of an aqueous extract of a traditional Chinese medicine prescription in the preparation of a medicine for treating senile dementia. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory impairment and related to multiple etiologies. The onset of the disease is insidious, and the main manifestations are progressive memory loss and cognitive dysfunction. Epidemiological surveys show that the prevalence of Alzheimer's disease accounts for about 10% of the elderly over 60 years old, and the incidence rate is increasing year by year. It is the main type of dementia in the elderly, accounting for 60% of the total incidence of dementia. %-70%. The pathogenesis of Alzheimer's disease has not yet been elucidated, and may involve gene mutations, mitochondrial dysfunction, neuroinflammatio...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P25/28A61K35/64
CPCA61K35/64A61K36/076A61K36/296A61K36/488A61K36/68A61K36/804A61K36/815A61K36/8994A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P25/28A61K2300/00
Inventor 龚其海邓媛媛石京山高健美李菲
Owner ZUNYI MEDICAL UNIVERSITY
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