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Nanoparticle/metal-organic framework material and its preparation method and application

A technology of organic frameworks and nanoparticles, applied in medical preparations of non-active ingredients, active ingredients of artificially synthesized polymeric materials, pharmaceutical formulations, etc., to achieve the effects of reducing treatment costs, easy access to raw materials, and simple methods

Active Publication Date: 2022-02-22
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no material that can be used as a monitoring carrier and a drug carrier at the same time in medicine

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  • Nanoparticle/metal-organic framework material and its preparation method and application

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preparation example Construction

[0029] In a second aspect, the present invention provides a method for preparing nanoparticles / metal-organic framework materials, comprising the following steps:

[0030] (1) providing an aqueous solution containing ferric ions and a solution containing an organic ligand and an organic solvent, respectively;

[0031] (2) Mix silver nanoparticles, an aqueous solution containing ferric ions, and a solution containing organic ligands and organic solvents, and react at 100-140° C. for 2-3 days under airtight conditions, separate solid-liquid, wash, dry;

[0032] Wherein, the organic ligand is terephthalic acid, 2-aminoterephthalic acid, 2-hydroxyterephthalic acid or 2-methylterephthalic acid.

[0033] Specifically, the aqueous solution containing ferric ions is an aqueous solution of oxygen-containing ferric ions obtained by dissolving a ferric source in the aqueous solution. Wherein, the source of ferric iron can be a conventionally used source of ferric iron, preferably FeCl ...

Embodiment 1

[0045] (1) 14.2mg of FeCl 3 Dissolve in 2.5mL of hydrochloric acid aqueous solution to prepare FeCl with a molar concentration of 0.035mol / L 3 Aqueous solution; 8.1 mg of 2-aminoterephthalic acid was dissolved in 7.5 mL of N,N-dimethylformamide to prepare an organic ligand solution with a molar concentration of 0.006 mol / L;

[0046] (2) 13.5 mg of silver nanoparticles, the above 2.5 mL of FeCl 3 The aqueous solution and the above-mentioned 7.5mL organic ligand solution were placed in a reaction kettle, 25KHz ultrasonically mixed for 8 minutes, and then placed in an oven. The heating temperature was set to 120°C, and the heating time was 60h. And use N,N-dimethylformamide to wash the solid particles obtained after filtration, and dry to obtain nanoparticles / metal-organic framework materials, whose chemical formula is: Ag 5.2 Fe(OH)(C 8 o 4 NH 5 ).

Embodiment 2

[0048] (1) 24.2mg of Fe(NO 3 ) 3 9H 2 O was dissolved in 2mL of nitric acid aqueous solution to prepare Fe(NO 3 ) 3 Aqueous solution; 10.0 mg of terephthalic acid was dissolved in 8 mL of N,N-dimethylacetamide to prepare an organic ligand solution with a molar concentration of 0.0075 mol / L;

[0049] (2) 10.2 mg of silver nanoparticles, the above 2 mL of Fe(NO 3 ) 3 The aqueous solution and the above-mentioned 8mL organic ligand solution were placed in a reaction kettle, mixed with 20KHz ultrasonic waves for 10 minutes, and then placed in an oven. The heating temperature was set to 140°C, and the heating time was 48 hours. N,N-dimethylacetamide washes the solid particles obtained after filtration, and dries to obtain nanoparticles / metal-organic framework materials, whose chemical formula is: Ag 1.6 Fe(OH)(C 8 o 4 h 4 ).

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Abstract

The present invention relates to nanocomposite material, discloses a kind of nanoparticle / metal-organic framework material, and its chemical formula is: Ag x Fe(OH)(M); In the formula, M is terephthalic acid, 2-aminoterephthalic acid, 2-hydroxyl terephthalic acid or 2-methyl terephthalic acid; x=0.5-6. The invention also discloses a preparation method of the nanoparticle / metal-organic framework material and its application as a magnetic resonance imaging agent, a drug carrier and an antibacterial agent. The material can be used as a magnetic resonance imaging agent and a drug carrier at the same time. Based on this system, it can achieve the purpose of treatment while achieving the purpose of diagnosis, reducing the pain of patients who need to take multiple medicines during the treatment process, and at the same time, it can be more accurately monitored. treatment effect and reduce treatment cost.

Description

technical field [0001] The invention relates to a nanocomposite material, in particular to a nanoparticle / metal-organic framework material. In addition, the invention also relates to a preparation method and application of nanoparticle / metal-organic framework material. Background technique [0002] With the progress of society and the improvement of people's living standards, people pay more and more attention to health problems. However, clinically, the relative independence and disconnection of diagnosis and treatment often lead to the miss of the best treatment effect. During the course of treatment, the inability to accurately locate and monitor the diseased tissue in real time may reduce the therapeutic effect. Moreover, due to the lack of state monitoring of the diseased tissue after treatment, it affects the clinical evaluation of the effectiveness of the treatment. [0003] Metal-organic frameworks (MOFs) have high porosity, large specific surface area, adjustable...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00A61K31/80A61K49/10A61K47/12A61P31/04
CPCC08G83/008A61K31/80A61K49/106A61K47/12A61P31/04
Inventor 林文鑫黄霞娟余世桨王岩高林辉祝洪良陈建军
Owner ZHEJIANG SCI-TECH UNIV
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