Solubilization of chlorhexidine base, anitseptic composition and disinfectant composition

A technology of antibacterial composition and chlorhexidine, which is applied in the direction of antibacterial drugs, drug combinations, local antibacterial agents, etc., and can solve the problems of not showing bactericidal activity of chlorhexidine base

Inactive Publication Date: 2020-06-02
太阳系统有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been demonstrated that the solubilized chlorhexidine base obtained using nonionic surfactants actually exhibits the greatest bactericidal and other types of activity
[0023] However, the actual bactericidal activity of the obtained solubilized form of chlorhexidine base was not shown

Method used

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  • Solubilization of chlorhexidine base, anitseptic composition and disinfectant composition
  • Solubilization of chlorhexidine base, anitseptic composition and disinfectant composition
  • Solubilization of chlorhexidine base, anitseptic composition and disinfectant composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1. To obtain 100 ml of an antibacterial composition in the form of a concentrate, at room temperature, 1 ml of amine oxide Barlox-12 (catalogue of the company Lonza) was dissolved in 100 ml of water, 0.15 g of chlorhexidine base, 0.05 g of glycine, 0.01 gDye E133. The obtained composition with pH 7.5-8 is an antimicrobial concentrate.

Embodiment 2

[0047] Example 2. Proceed similarly to Example 1, but the composition contained 0.5g chlorhexidine base, 3.5ml Barlox 12, 1.5g alanine, 2ml glycerol, 0.05g acid red (E122).

Embodiment 3

[0048] Example 3. Proceed similarly to Example 1, but the composition comprises 1 g chlorhexidine base, 5 ml Barlox 12, 2.0 g glutamine, 2 ml glycerin, 0.05 g anthraquinone dye.

[0049] A series of experiments were performed to confirm the antimicrobial composition against Mycobacterium tuberculosis, MDR multidrug-resistant strains and extremely drug-resistant XDR (which is insensitive to class 1, 2 and 3 antimicrobials) and pan-drug-resistant PDR ( It is highly active against all known antimicrobial agents of all classes). Clinical (wild) MDR, XDR isolated from laboratory strains of Mycobacterium tuberculosis H37Rv and diagnostic material from tuberculosis patients treated in hospitals of the Central Institute of Tuberculosis of the Russian Academy of Medical Sciences (RAMS) and PDR strains were used as biological test articles. Two clinical strains were characterized and labeled FEEL-1 and FEEL-2 considering the effect of anti-TB drugs on them when sensitive. Three other ...

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PUM

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Abstract

The present invention relates to a chlorhexidine base and to producing a solubilized form containing a chlorhexidine base aminio acid in the presence of amine oxide. The invention relates to medicineand the pharmaceutical industry, particularly to novel antiseptic and disinfectant compositions that are active toward Mycobacterium tuberculosis, including strains that are multidrug resistant MDR, extensively drug resistant XDR, and pandrug resistant PDR; bacterial spores; and fungi; and said compositions having virucidal activity.

Description

technical field [0001] The present invention relates to chlorhexidine base, the preparation of a solubilized form comprising chlorhexidine base and amino acids in the presence of amine oxides. The present invention relates to medicine and pharmaceutical industries, in particular to a novel drug which is active against Mycobacterium tuberculosis (comprising multidrug-resistant MDR bacterial strains, extremely drug-resistant XDR bacterial strains and pan-drug-resistant PDR bacterial strains), bacterial spores, fungi and has virucidal activity Antimicrobial and disinfecting compositions. Background technique [0002] Chlorhexidine is a biguanide. Chemically, chlorhexidine base is 1,1'-hexamethylenebis-[5-(4-chlorophenyl)biguanide]. The chlorhexidine molecule C is presented below in the form of the structural formula 22 h 30 CL 2 N 10 style. [0003] [0004] Chlorhexidine base is a white crystalline powder, almost insoluble in water and alcohol. [0005] Usually, chl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61P31/02A61K31/155A61K47/10A61K47/18A61L2/18A61L101/32
CPCA61K31/155A61L2/18A61P31/02A61P31/06A61K9/107A61K47/183A61K47/186A61K47/10A61K47/34A61K9/1075A61K9/5089A61K47/18A61P31/00A61L2/16A61L2/0082A01N47/44A01N33/06A01N33/08A01N37/44A01N33/12A61K9/4833
Inventor G·G·卡纳季J-C·雅特曼A·Y·雷查列夫E·N·哈普基那
Owner 太阳系统有限责任公司
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