Probiotic composition with anti-allergy effect

A composition and technology of probiotics, applied in the field of microorganisms, can solve the problem that common Lactobacillus can not play a role in skin itching, and achieve significant anti-allergic effects and high safety effects

Active Publication Date: 2020-06-19
赵一鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, it has been found that a variety of lactic acid bacteria have potential anti-allergic effects, but Lactobacillus vulgaris cannot play a role in skin itching caused by allergies such as urticaria

Method used

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  • Probiotic composition with anti-allergy effect
  • Probiotic composition with anti-allergy effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Activated bacteria:

[0025] Lactobacillus casei CGMCC 1.8727: Take a loop of Lactobacillus casei and inoculate it into the MRS solid medium for streaking, and culture it anaerobically at 37°C for 24 hours. Pick a single colony from the plate and inoculate it into MRS liquid medium for activation, and culture it anaerobically to 10 8 cfu / ml Lactobacillus casei CGMCC 1.8727 seed solution.

[0026] Lactobacillus crispatus CGMCC No.636: The method of activating the strain is the same as above. Finally configured to 10 8 cfu / ml Lactobacillus crispatus seed solution.

[0027] 2. Configure liquid

[0028] Zinc methionine solution (dissolved in lactic acid solution with pH 6.0), the concentration is 0.2mg / ml.

[0029] Zinc gluconate solution, the concentration is 0.2mg / ml.

[0030] 3. 90 KM female mice, weighing 22-25 g, were randomly divided into 9 groups (10 / group) and fed normally, and there was no statistical difference in the weight of the mice among the groups. ...

Embodiment 2

[0048] The operations of activating strains and configuring liquid are the same as in Example 1.

[0049] 90 KM female mice, weighing 20-25 g, were randomly divided into 9 groups (10 mice in each group) and fed normally, and there was no statistical difference in the weight of the mice among the groups. The 9 groups were blank control group, positive control group, cheese intervention group, curly curly intervention group, cheese + zinc methionine intervention group, curly + zinc methionine intervention group, cheese + curly intervention group, cheese + curly + zinc methionine intervention group, cheese + curly + zinc gluconate intervention group.

[0050] The specific treatment is as follows:

[0051] Blank control group: each mouse was given 0.22ml of normal saline by gavage;

[0052] Positive control group: intragastric administration of dexamethasone (2.5 mg / kg / day);

[0053] Cheese intervention group, curly curly intervention group, cheese + curly intervention group, c...

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PUM

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Abstract

The invention discloses a probiotic composition with an anti-allergy effect. The probiotic composition comprises lactobacillus casei, lactobacillus crispatus and zinc methionine. Preferably, the composition can be made into tablet candies, powder in bags and capsules. Preferably, the lactobacillus casei is lactobacillus casei CGMCC 1.8727. Preferably, the lactobacillus crispatus is lactobacillus crispatus CGMCC No.6364.

Description

technical field [0001] The invention relates to an anti-allergic probiotic composition, which belongs to the technical field of microbes. Background technique [0002] Under normal circumstances, when foreign substances enter the human body, most of them face two fates. If they are recognized by the body as useful or harmless substances, these substances will live in harmony with the human body and will eventually be absorbed, utilized or naturally excreted. If these substances are identified as harmful substances, the body's immune system will respond immediately to expel or eliminate them, which is the protective effect of the immune response. The immune response is one of the important functions of the human defense system, but if this response exceeds the normal range, that is, when the immune system attacks a harmless substance, this situation is called an allergic reaction. Allergy is a disease, because unprovoked attacks can also damage normal body tissues, and even ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L33/165A61K35/747A61P37/08A61P17/04A61K31/198
CPCA23L33/135A23L33/165A61K35/747A61K33/30A61P37/08A61P17/04A23V2002/00A23V2400/125A23V2200/30A23V2200/318A23V2200/3204A23V2200/324A23V2250/1642A61K2300/00
Inventor 赵一鸣
Owner 赵一鸣
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